SOLANUM BETACEUM IMPROVES COGNITIVE FUNCTION BY DECREASING N-METHYL-D-ASPARTATE ON ALZHEIMER RATS MODEL

INDRI SAFITRI; HANIK BADRIYAH HIDAYATI; AGUS TURCHAN; SUHARTATI; SITI KHAERUNNISA

doi:10.22159/ijap.2019.v11s5.T1015

Authors

INDRI SAFITRI Department of Biochemistry, Faculty of Medicine, Airlangga University, Indonesia.
HANIK BADRIYAH HIDAYATI Department of Neurology, Airlangga University, Dr. Soetomo General Hospital, Indonesia.
AGUS TURCHAN Department of Neurosurgeon, Airlangga University, Dr. Soetomo General Hospital, Indonesia.
SUHARTATI Department of Medical Biochemistry, Wijaya Kusuma University, Indonesia.
SITI KHAERUNNISA Department of Biochemistry, Faculty of Medicine, Airlangga University, Indonesia.

DOI:

https://doi.org/10.22159/ijap.2019.v11s5.T1015

Keywords:

Solanum betaceum, Memory, N-Methyl-D-Aspartate receptor, Brain-derived neurotrophic factor, Aluminum chloride, Alzheimer

Abstract

Objective: The purpose of this study was to evaluate the effect of Solanum betaceum towards cognitive function, i.e. memory, and the level of N-Methyl-
D-Aspartate receptor (NMDAR) and brain derived neurothropic factor (BDNF) as a drug candidate therapy for Alzheimer rats model.
Methods: Fifty adult male albino rats were divided into five groups (K0, K1, P1, P2 and P3). Four groups (K1, P1, P2 and P3) of Alzheimer’s disease
(AD) rats were induced by aluminum chloride with dose 2 g/L for 21 days period and three groups (P1, P2 and P3) in 22th day administered parallelly
with 100 mg/kg b.w/day; 200 mg/kg b.w/day; and 400 mg/kg b.w/day of S. betaceum respectively for14 days. The level of NMDAR and BDNF was
measured by enzyme-linked immunosorbent assay methods, whereas memory was measured by the Morris water maze test.
Results: S. betaceum administration increased cognitive function significantly (p=0.037) of AD induced-rats by decreasing the time to reach the target
of Morris water maze and maintaining the low levels of NMDAR significantly (p=0.006), but the level of BDNF did not increase significantly (p=0.346).
These results indicated that ethanol extracts of S. betaceum could decrease brain NMDAR and increase cognitive function by promote better memory
function but did not significant increased the level of BDNF in AD-induced rats.
Conclusion: This study revealed that the treatment of AD-induced rats with S. betaceum extracts significantly improve memory function and decrease
the level of NMDAR.

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