DESIGN AND OPTIMIZATION OF MICROPARTICULATE RESERVOIR MATRICES FOR COMBINATION THERAPY
DOI:
https://doi.org/10.22159/ijap.2020v12i3.36614Keywords:
Anti-inflammatory, Ketoprofen, Pantoprazole sodium, Alginate beads, Ionotropic gelationAbstract
Objective: The purpose of this investigation was to design and develop controlled release floating beads of Ketoprofenand Pantoprazole sodium. To determine the interaction between excipients used and to find out the nature of drug in the formulation, X-ray diffraction (XRD) and Differential Scanning Colorimetry (DSC) studies were performed.
Methods: The beads were prepared by ionotropic gelation technique. Sodium alginate and HPMC E5LV was dissolved in deionized water (9:1 sodium alginate: HPMC E5LV) at a concentration of 1-3 % w/v using gentle heat on the water bath. After getting a clear solution, an accurately weighed quantity of Pantoprazole sodium was added and dispersed uniformly into the solution. In a separate beaker, Ketoprofen and calcium carbonate (1:1, Sodium alginate: CaCl2) was dispersed in water and mixed with sodium alginate solution containing Pantoprazole sodium. The bubble-free sodium alginate-drug dispersion (20 ml) was added dropwise via a 22-guage hypodermic needle fitted with a 10 ml syringe into 100 ml of calcium chloride solution (1-2 % w/v) containing 10 % glacial acetic acid and stirred at 400 rpm for 15 min.
Results: From the experimental study, it was concluded that optimized batch F9 showed good micromeritic properties, entrapment efficiency and releases the drug slowly and completely for 12 h as beads remain in floating condition throughout dissolution study that assures prepared formulation remain floated in the stomach without its early passing to lower Gastro-Intestinal Tract(GIT) side. The percentage of drugs release of Ketoprofen and Pantoprazole Sodium was 96.56% and 97.74%, respectively at 12 h.
Conclusion: Combination of different polymer provide sustained release pattern in different concentration. Formulation F9 gives good floating behavior using sodium alginate and HPMC hydroxypropyl methylcellulose in different ratios. In the present study, a satisfactory attempt has been made to formulate gastro retentive floating beads of Ketoprofen and Pantoprazole sodium.
Downloads
References
Badoni A, Ojha A, Nanarajan G, Kothiyal GP. Review on gastro retentive drug delivery system. Pharm Innov 2012;8:32-42.
Sandhya P, Farhath A, Benazir F, Durani HZ. A review on the gastro retentive drug delivery system of helicobacter pylori. Int J Pharma Res Rev 2013;3:403-22.
Badoni A, Ojha A, Nanarajan G, Kothiyal GP. Review on gastro retentive drug delivery system. Pharm Innov 2012;8:32-42.
Kumar PR, Doddayya H, Reddy SR. Floating tablets for Helicobacter pylori-induced peptic ulcer therapy: a research review on formulation studies, in vitro and in vivo evaluation. J Biomed Pharm Res 2012;1:39-52.
Prajapati ST, Patel LD, Patel DM. Gastric floating matrix tablets: Design and optimization using a combination of polymers. Acta Pharm 2008;58:221–9.
Dixit N. Floating drug delivery system. J Curr Pharm Res 2011;7:6-20.
Lewis GA, Mathieu D, Phan-Tan-Luu R. Pharmaceutical experimental design, Marcel Dekker; 1961.
Singh B, Ahuja N. Book review on pharmaceutical experimental design; 1999.
Nelson KG, Wang LY. Determination of time course of tablet disintegration II: Method using continuous functions. J Pharm Sci 1978;67:86–9.
Singh B, Dahiya M, Saharan V, Ahuja N. Optimizing drug delivery systems using systematic "design of experiments." Part II: retrospect and prospects. Crit Rev Ther Drug Carrier Syst 2005;22:215–94.
Singh B, Mehta G, Kumar R, Bhatia A, Ahuja N, Katare OP. Design, development and optimization of nimesulide-loaded liposomal systems for topical application. Curr Drug Delivery 2005;2:143–53.
Aberturas MR, Molpeceres J, Guzmıan M, Garcııa F. J Microen; 2002. p. 61–72.
Patel N, Lalwani D, Gollmer S, Injeti E, Sari Y, Nesamony J. Development and evaluation of a calcium alginate based oral ceftriaxone sodium formulation. Prog Biomater 2016;5:117-33.
Nappinnai M, Sivaneswari S. Formulation optimization and characterization of gastroretentive cefpodoxime proxetil mucoadhesive microspheres using 32 factorial design. J Pharm Res 2013;7:304-9.
Bulgarelli E, Forni F, Bernabei MT. Effect of matrix composition and process conditions on casein-gelatin beads floating properties. Inter J Pharm 2000;198:157-65.
El-Badry M, Fetih G, Fathy M. Improvement of solubility and dissolution rate of indomethacin by solid dispersions in Gelucire 50/13 and PEG4000. Sau Pharm J 2009;17:217–25.
Srikanthn MV, Rao NS, Sunil SA, Ram BJ, Kolapalli VRM. Statistical design and evaluation of a propranolol HCl gastric floating tablet. Acta Pharm Sin B 2012;2:60–9.
Mandal S, Kumar SS, Krishnamoorthy B, Sanat Kumar Basu SK. Development and evaluation of calcium alginate beads prepared by sequential and simultaneous methods. Braz J Pharm Sci 2010;46:785-93.
