FORMULATION AND EVALUATION OF ETHAMBUTOL POLYMERIC NANOPARTICLES

MONOWAR HUSSAIN; ANUPAM SARMA; SHEIKH SOFIUR RAHMAN; ABDUL MATIN SIDDIQUE; TANUKU PAVANI EESWARI

doi:10.22159/ijap.2020v12i4.36845

Authors

MONOWAR HUSSAIN Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam 786004
ANUPAM SARMA Pratiksha Institute of Pharmaceutical Sciences, Guwahati, Assam 781026
SHEIKH SOFIUR RAHMAN Girijananda Chowdhury Institute of Pharmaceutical Science (GIPS), Azara, Hatkhowapara, NH-37, Guwahati, Assam 781017
ABDUL MATIN SIDDIQUE Annai Veilankanni’s Pharmacy College, V. G. P. Salai, Saidapet, Chennai 600015
TANUKU PAVANI EESWARI Koringa College of Pharmacy, Pata, Korangi, Andhra Pradesh 533461

DOI:

https://doi.org/10.22159/ijap.2020v12i4.36845

Keywords:

Mycobacterium tuberculosis, Ethambutol, Eudragit, Polymeric nanoparticle

Abstract

Objective: Tuberculosis (TB) is an infectious bacterial disease caused by Mycobacterium tuberculosis which most commonly affects the lungs. TB has the highest mortality rate than any other infectious disease occurs worldwide. The main objective of the present investigation was to develop polymeric nanoparticles based drug delivery system to sustain the ethambutol (ETB) release by reducing the dose frequency.

Methods: The Preformulation studies of drug ETB were done by physical characterization, melting point determination, and UV spectrophotometric analysis. The ETB loaded nanoparticles were prepared by double-emulsion (W/O/W) solvent evaporation/diffusion technique. The prepared polymeric nanoparticles were evaluated for particle size, polydispersity index, zeta potential, drug entrapment efficiency, drug loading, drug-polymer compatibility study, surface morphology, in vitro drug release, and release kinetics.

Results: Based on the result obtained from the prepared formulations, F11 showed the best result and was selected as the optimized formulation. Optimized batch (F11) showed better entrapment efficiency (73.3%), good drug loading capacity (13.21%), optimum particle size (136.1 nm), and zeta potential (25.2 mV) with % cumulative drug release of 79.08% at the end of 24 h.

Conclusion: These results attributed that developed polymeric nanoparticles could be effective in sustaining the ETB release over 24 h. Moreover, the developed nanoparticles could be an alternate method for ETB delivery with a prolonged drug release profile and a better therapeutic effect can be achieved for the treatment of tuberculosis.

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