FORMULATION AND EVALUATION OF LIQUID CRYSTAL EMULSION CONTAINING EXTRA VIRGIN OLIVE OIL AS SKIN ANTI-AGING

ULVA DWI AYU SEPTIANINGSIH; JULIA REVENY; ANAYANTI ARIANTO

doi:10.22159/ijap.2020v12i4.37397

Authors

ULVA DWI AYU SEPTIANINGSIH Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia
JULIA REVENY Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia
ANAYANTI ARIANTO Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia

DOI:

https://doi.org/10.22159/ijap.2020v12i4.37397

Keywords:

Liquid crystal emulsion, Extra virgin olive oil, Skin anti-aging

Abstract

Objective: The purpose of this research was to formulate and evaluate the and anti-aging activity and the characteristic of liquid crystal emulsion of extra virgin olive oil (EVOO).

Methods: Preparation of liquid crystal emulsion was made using the variation of alkyl polyglycoside and caprylic triglyceride as surfactant with concentration ratio was 3:5 (F1), 4:4 (F2), 5:3 (F3) and 5% extra virgin olive oil as an anti-aging substance. The liquid crystal emulsions were evaluated for an organoleptic test, microscopic, pH value, viscosity, particle size, zeta potential during 12 w storage at room temperature and centrifugation test. The selected liquid crystal emulsion was examined with anti-aging activity (moisture, pore, spot, and wrinkle) using a skin analyzer to volunteer’s skin.

Results: The result showed that all formulas had stable storage for 12 w at room temperature (25±1 °C). Liquid crystal emulsion with a surfactant concentration of alkyl polyglycosides and caprylic triglycerides 4:4 (F2) showed the presence of liquid crystal, the stable value of pH (6.9) and viscosity (4995 mPa), smallest particle size 5.727 µm, and highest zeta potential-34.5 mV after 12 w storage at room temperature.

Conclusion: EVOO liquid crystal emulsion (F2) showed better skin anti-aging activity (condition of moisture content, pore, spot, and wrinkle) than conventional emulsion. It concluded that the formula was stable physically and showed better skin anti-aging activity than conventional emulsion.

Downloads

Download data is not yet available.

References

Nazliniwaty N, Suryanto S, Damanik DD. The utilization of binahong (Anredera cordifolia (Ten.) Steenis) leaf as an anti-aging. Asian J Pharm Clin Res 2018;11:87.

Iya A, Geeta A, Gitika AD, Manju N. Herbal active ingredients used in skin cosmetics. Asian J Pharm Clin Res 2019;12:7–15.

Yaar M, Gilchrest BA. Photoaging: mechanism, prevention, and therapy. Br J Dermatol 2007;157:874-7.

Oliveira LB, Oliveira RF, Oliveira C, Raposo NR, Bradão MA, Ferreira AO, et al. Cosmetic potential of a liotropic liquid crystal emulsion containing resveratrol. Cosmetics 2017;7:1-3.

Santis SD, Cariello M, Piccinin E, Sabbà C, Moschetta A. Extra virgin olive oil: lesson from nutrigenomics. Nutrients 2019;11:2.

Viola P, Viola M. Virgin olive oil as a fundamental nutritional component and skin protector. Clin Dermatol 2009;27:159-60.

Orey C. Benefits of olive oil mediterranean longevity recipe. Jakarta: Hikmah; 2008. p. 10.

Waterman E, Lockwood B. Active components and clinical applications of olive oil. Altern Med Rev 2007;12:331-2.

Bernegossi J, Barbosa RM, Rustice PM, Chorilli M. Green tea glycolic extract-loaded liquid crystal systems: development, characterization and microbiological control. Braz J Pharm Sci 2016;52:383-7.

Zanatta CF, de Faria Sato AC, de Camargo Junior FB, Campos PM, Rocha-Filho PA. Rheological behavior, zeta potential, and accelerated stability test of buriti oil (Mauritia flexuosa) emulsions containing the lyotropic liquid crystal. Drug Dev Ind Pharm 2010;36:93-101.

Zhang W, Liu L. Study on the formation and properties of liquid crystal emulsion in cosmetics. J Cosmet Dermatol Sci 2013;3:139-41.

Preziosi V, Perazzo A, Caserta S, Tomaiuolo G, Guido S. Phase inversion emulsification. Chem Eng Trans 2013;32:1585-90.

Föster TH, Schambil F, Tesmann H. Emulsification by the phase inversion temperature method: the role of self-bodying agents and the influence of oil polarity. Int J Cosmetic Sci 1990;12:217-27.

Fernandez P, Andre V, Rieger J, Kühnle A. Nano-emulsion formation by emulsion phase inversion. Colloids Surface A 2004;251:53-8.

Terescenco D, Picard C, Clemenceau F, Grisel M, Savary G. Influence of the emollient structure on the properties of cosmetic emulsion containing lamellar liquid crystals. Colloids Surface A 2017;25:10-9.

Medina WS, Praça FS, Carollo AR, Bentley MV. Nanocarriers to deliver photosensitizers in topical photodynamic therapy and photodiagnostivs. In: Beck R, Guterres S, Pohlmann A. Nanocosmetics and Nanomedicines; 2011. p. 298-9.

Friberg SE. Micelles, microemulsions, liquid crystals, and the structure of stratum corneum lipids. J Soc Cosmet Chem 1990;41:155-71.

Harry RG. Harry’s Cosmetology. Seventh Edition. London: Leonard Hill Book; 2000. p. 108.

Alam MM, Aramaki K. Liquid crystal-based emulsions: progress and prospect. J Oleo Sci 2014;63:97-108.

Stepien JB, Jaremek H, Pielak GF. Liquid-crystal emulsion oil in water type and a preparation method of the liquid-crystal emulsion. US008658058B2; 2014. p. 2.

Gao L, Zhang D, Chen M. Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system. J Nanopart Res 2008;10:845–62.

Andrade FF, Santos OD, Oliviera WP, Rocha Filho PA. Influence of PEG-12 dimethicone addition on stability and formation of emulsions containing liquid crystal. Int J Cosmetic Sci 2007;29:211-8.

Lachman L, Lieberman HA, Kanig JL. Theory and practice of Industrial pharmacy. Jakarta: Universitas Indonesia Press; 1994.

Lin T, Zhong L, Santiago JL. Anti-Inflammatory and skin barrier repair effect of topical application of some plant oils. Int J Mol Sci 2018;19:4.

Iwai H, Fukasaw J, Suzuki T. A liquid crystal application in skincare cosmetics. Int J Cosmetic Sci 1998;20:87-102.

Musashi M, Coler Reilly A, Nagasawa T, Kubota Y, Kato S, Yamaguchi Y. Liquid crystal gel reduces age spots by promoting skin turnover. Cosmetics 2014;25:202-10.