ROLE OF HERBAL PLANTS IN THE DIABETES MELLITUS THERAPY: AN OVERVIEW
Keywords:Diabetes Mellitus, Insulin, Hypoglycaemicagents, Herbaltreatment
Diabetes mellitus has been recognized as a growing worldwide epidemic by much health's advocacy group. The World Health Organization (WHO) has estimated that diabetes will be one of the world leading causes of death and disability with next quarter century.There are a unit Associate in nursing calculable 143 million folks within the world with diabetes and this variety will most likely double by the year 2030. Oral hypoglycaemic agents like sulphonylureas and biguanides are still the major players in the management of the disease but there is growing interest in herbal remedies due to the side effects associated with the oral hypoglycemic agents. Herbal medicines have been highly esteemed source of medicine throughout the human history. They are widely used today indicating that herbs are a growing part of modern high-tech medicine.In recent times, there has been a revived interest within the plant remedies. In this review article an attempt has been made to focus on hypoglyceamic plants and may be useful to the health professionals, scientists and scholars working in the field of pharmacology & therapeutics to develop evidence based alternative medicine to cure different kinds of diabetes in man and animals.
Keywords: Diabetes Mellitus, Insulin, Hypoglycaemic agents, Herbal treatment.
Mulholland DA, Chukwujekwu JC, Smith P, Coombes PH, Van-Standen J. Antispasmodial diterpenoid from leaves of Hyptis suaveoleus. J Ethanopharmacol 2005;102:295-7.
Sangeeta R, Sudhir C, Pradeep S, Garima M, Jha KK, Khosa RL. Cressa Cretica Linn: an important medicinal plant-A review on its traditional uses, phytochemical and pharmacological properties. J Nat Prod Plant Resour 2011;1:91-100.
Maurya U, Srivastava S. Traditional Indian Herbal medicine used as antipyretic, antiulcer, antidiabetic and anticancer: a review. IJRPC 2011;1:1152-9.
Ignacimuthu S, Ayyanar M, Sivaraman SK. Ethnobotanical investigations among tribes in Madurai district of Tamil Nadu (India). J Ethnobiol Ethnomed 2006;2:1-7.
Elujoba AA, Odeleye OM, Ogunyemi CM. Traditional medicine development for medical and dental primary health care delivery system in Africa. Afr J Tradit Complementary Altern Med 2005;2:46-61.
Tomlinson TR, Akerele O. Medicinal plants: their role in health and biodiversity. University of Pennsylvania Press, Philadelphia; 1998. p. 11-41.
Kochhar A, Nagi M. Effect of supplementation of traditional medicinal plants on blood glucose in nonâ€“insulin-dependent diabetics: a pilot study. J Med Food 2005;8:545â€“9.
Zibula SMX, Ojewole JAO. Hypoglycemic effects of Hypoxis hemerocallidea corm â€˜African potato' methanolic extract in rats. Med J Islamic Academy Sci 2000;13:75-8.
International Diabetes Federation. Brussels, Belgium: International Diabetes Federation. IDF Diabetes Atlas, 5th edn; 2011.
WHO-World Health Organization. Diabetes Fact Sheet Number 312; 2006.
Davidson MB. Diabetes mellitus: Diagnosis and treatment. Churchill Livingstone Incorporated. USA; 1991.
Andrade-Cetto A, Heinrich M. Mexican plants with hypoglycemic effect used in the treatment of diabetes. J Ethnopharmacol 2005;99:325â€“48.
Attele AS, Zhou Y, Xie J, Wu JA, Zhang L, Dey L, et al. Antidiabetic effects of Panax ginseng Berry extract and the identification of an effective component. Diabetes 2002;51:1851-8.
Ramachandran A, Snehalatha C, Viswanathan V. Burden of type 2 diabetes and its complicationsâ€“The Indian scenario. Curr Sci 2002;83:1471-6.
Sofowora A. Research on medicinal plants and traditional medicine in Africa. JCAM 1996;2:365-72.
Kesari AN, Gupta RK, Watal G. Hypoglycemic effect of Murraya koenigii on normal and alloxan diabetic rabbits. J Ethnopharmacol 2005;97:247-51.
Gupta RK, Kesari AN, Murthy PS, Chandra R, Tandon V, Watal G. Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals. J Ethnopharmacol 2005;99:75-81.
Kako M, Miura T, Nishiyama Y, Ichimaru M, Moriyasu M, Kato A. Hypoglycemic activity of some triterpenoid glycosides. J Nat Prod 199l;60:604â€“5.
Shruthi A, Latha KP, Vagdevi HM, Pushpa B, Shwetha C. Antidiabetic activity of the leaves extracts of Wrightia Tinctoria on alloxan induced diabetic rats. J Chem Pharm Res 2012;4:3125-8.
Sunil Kumar, Smita Narwal, Dinesh Kumar, Gurvirender Singh, Sumit Narwal, Renu Arya. Evaluation of antihyperglycemic and antioxidant activities of Saraca asoca (Roxb.) De. Wild leaves in streptozotocin induced diabetic mice. Asian Pac J Trop Dis 2012;170-6.
Khan MRI, Islam MA, Hossain MS, Asadujjaman M, Wahed MII, Rahman BM, et al. Antidiabetic effects of the different fractions of ethanolic extracts of ocimum sanctum in normal and alloxan induced diabetic rats. J Sci Res 2010;2:158-68.
Virendra Singh, Mohan Lal Kori. Antidiabetic effect of hydroalcoholic combined plant extract of portulaca oleracea and caralluma attenuata in streptozotocin induced diabetic rats. Indo Am J Pharm Res 2014;4:1391-6.
Ahmed I, Adeghate E, Cummings E, Sharma AK, Singh J. Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat. Mol Cell Biochem 2004;261:63-70.
Platel K, Srinivasan K. Plant foods in the management of diabetes mellitus: vegetables as potential hypoglycaemic agents. Nahrung 1997;41:68-74.
Day C. Traditional plant treatments for diabetes mellitus: pharmaceutical foods. Br J Nutr 1998;80:203â€“8.
Ajithadas Aruna, Ramraj Nandhini, Venkatachalam Karthikeyan, Pandi Bose, Kannappan Vijayalakshmi. Comparative anti-diabetic effect of methanolic extract of insulin plant (costus pictus) leaves and its silver nanoparticle. Indo Am J Pharm Res 2014;4:3217-30.
Kato A, Miura T, Fukunaga T. Effects of steroidal Glycosides on blood glucose in normal and diabetic mice. Biol Pharm Bull 1995;18:167â€“8.
Witters LA. Understanding the benefit of metformin use in cancer treatment. J Clin Invest 2001;108:1105â€“7.
Bailey C, Day C. Metformin: its botanical background. Pract Diabetes Int 2004;21:115â€“7.
Eddouks M, Jouad H, Maghrani M, Lemhadri A, Burcelin R. Inhibition of endogenous glucose production accounts for hypoglycemic effect of Spergularia purpurea in streptozotocin mice. Phytomed Int J Phytother Phytopharmacol 2003;10:594-9.
Kesari AN, Kesari S, Santosh KS, Rajesh KG, Geeta W. Studies on the glycemic and lipidemic effect of Murraya koenigii in experimental animals. J Ethnopharmacol 2007;112:305â€“11.
Sabu MC, Subburaju T. Effect of Cassia auriculata Linn. on serum glucose level, glucose utilization by isolated rat hemidiaphragm. J Ethnopharmacol 2002;80:203â€“6.
Wadkar KA, Magdum CS, Patil SS, Naikwade NS. Anti-diabetic potential and Indian medicinal plants. J Herb Med Toxicol 2008;2:45-50.