DEVELOPMENT OF COPROCESSED EXCIPIENTS OF XANTHAN GUM AND ACACIA GUM AS A CONTROLLED RELEASE MATRIX FOR FAMOTIDINE FLOATING TABLETS

Authors

  • UNSYURA DHIPA BUDAYA Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia Department of Production, Drs. Mochamad Kamal Pharmaceutical Division of Indonesia Navy, Jakarta, Indonesia
  • SILVIA SURINI Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia

DOI:

https://doi.org/10.22159/ijap.2020.v12s1.FF044

Keywords:

Acacia gum, Coprocessed excipient, Famotidine, Floating tablet, Xanthan gum

Abstract

Objective: Controlled release floating tablets require excipients, which act as a matrix to control the release of the active drug and facilitate
the tablet floating in the gastric milieu. One potential excipient is coprocessed excipients of xanthan gum and acacia gum (Co-XG-GA), which is
a physical modification of the two natural polymers. In this study, we produced several Co-XG-GA and used them as matrices in floating tablet
formulations.
Methods: Several coprocessed excipients were prepared from xanthan gum and acacia gum at ratios of 1:1, 1:2, 2:1, 1:3, and 3:1. The obtained
excipients were then characterized physically, chemically, and functionally. The coprocessed excipients were then formulated in floating tablets using
famotidine as the drug model. The floating tablets were then evaluated in terms of the tablet floating capabilities and the drug release in HCl medium
at pH 1.2 for 8 h.
Results: Our results showed that the coprocessed excipients were a fine powder, odorless, and a grayish-white color. The excipients had a good
swelling index, fairly large viscosity, and good gel strength; hence, they were suitable to be applied as the matrices of floating tablet formulations. The
floating tablets of F2, which contained the Co-XG-GA 1:2, demonstrated the best characteristics with 8.33±0.58 min of floating lag time and 24 h of
total floating time. Further release studies revealed that the famotidine floating tablets, which used Co-XG-GA (F1–F5) as matrices, controlled drug
release with zero-order release kinetics and could be used for controlled release dosage forms.
Conclusion: Collectively, our results indicate that the Co-XG-GA can be applied as matrices in controlled release floating tablets

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References

1. Arora S, Ali J, Ahuja A, Khar RK, Baboota S. Floating drug delivery
systems: A review. AAPS PharmSciTech 2005;6:E372-90.
2. Khan F, Ibn Razzak SM, Khan ZR, Azad MA, Chowdhury JA,
Reza S. Theophylline loaded gastroretentive floating tablets based on
hydrophilic polymers: Preparation and in vitro evaluation. Pak J Pharm
Sci 2009;22:155-61.
3. Shaikh A, Shaikh P, Pawar Y, Kumbhar S, Katedeshmukh R. Effect of
gums and excipients on drug release of ambroxol HCl sustained-release
matrices. J Curr Pharm Res 2010;6:11-5.
4. Chougule AS, Dikpati A, Trimbake T. Formulation development
techniques of co-processed excipients. J Adv Pharm Sci 2012;2:231-49.
5. Surini S, Ariani L, Putri KS, Hayun H. Coprecessed excipients of
crosslinked amylose and xanthan gum for use in controlled release
dosage forms. Int J App Pharm 2018;10:59-65.
6. The United States Pharmacopoeia Convention. United States
Pharmacopoeia 32nd and National Formulary 27th. Rockville: The USP
Convention; 2009.
7. Bigucci F, Luppi B, Cerchiara T, Sorrenti M, Bettinetti G, Rodriguez L,
et al. Chitosan/pectin polyelectrolyte complexes: Selection of suitable
preparative conditions for colon-specific delivery of vancomycin. Eur J
Pharm Sci 2008;35:435-41.
8. Kumar R, Patil MB, Patil SR, Paschapur MS. Formulation and
evaluation of effervescent floating tablet of famotidine. Int J Pharm
Tech Res 2009;1:754-63.
9. Siepmann J, Peppas NA. Modeling of drug release from delivery
systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug
Deliv Rev 2001;48:139-57.
10. Carbinatto FM, de Castro AD, Cury BS, Magalhães A, Evangelista RC.
Physical properties of pectin-high amylose starch mixtures cross-linked
with sodium trimetaphosphate. Int J Pharm 2012;423:281-8.
11. Patil MS, Vidyasagar G, Patil VB. Formulation, optimization and
evaluation of floating tablets clarithromycin. Int J Pharm Pharm Sci
2015;7:320-6.

Published

23-03-2020

How to Cite

BUDAYA, U. D., & SURINI, S. (2020). DEVELOPMENT OF COPROCESSED EXCIPIENTS OF XANTHAN GUM AND ACACIA GUM AS A CONTROLLED RELEASE MATRIX FOR FAMOTIDINE FLOATING TABLETS. International Journal of Applied Pharmaceutics, 12(1), 192–196. https://doi.org/10.22159/ijap.2020.v12s1.FF044

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Original Article(s)