S100B AS A SEROLOGIC MARKER FOR COGNITIVE DYSFUNCTION FOLLOWING OPEN-HEART SURGERY
DOI:
https://doi.org/10.22159/ijap.2020.v12s3.39473Keywords:
Cardiac surgery, POCD, S100BAbstract
Objective: Postoperative cognitive dysfunction (POCD) can feature a wide spectrum of clinical symptoms, from asymptomatic to debilitating dementia, that lead to increased dependence, lower quality of life, morbidity, and mortality. Protein S100B is a direct marker for neuronal cell damage. We aimed to evaluate S100B as a biomarker for predicting POCD following open-heart surgery.
Methods: This was an observational-analytic study to assess changes of the S100B level following open-heart surgery in Cipto Mangunkusumo Hospital, Jakarta. All subjects underwent cognitive function evaluations that consisted of six psychometric tests on the day prior to surgery and five days after surgery. Cognitive dysfunction was determined if there was a>20% cognitive score drop from baseline values in at least two tests. Blood samples for S100B were obtained (1) before the induction of anesthesia and (2) six hours after surgery. Samples were analyzed using enzyme-linked immunosorbent assay for S100B. All data were analyzed using SPSS 20.
Results: Among the 55 subjects analyzed, 31 (56.4%) were found to have a decline in cognitive function. There were no differences in baseline characteristics, comorbidities, and perioperative data. Oxygen contents also did not show significant differences at any time. The S100B levels in all subjects increased. This increase was>1.5x higher in subjects with POCD compared to those without POCD (2.15[0.22–60.03] vs. 1.33[0.15–19.77] ng/ml, p = 0.16). However, this difference was not statistically significant.
Conclusion: This study showed that serum S100B is higher in POCD patients and has the potential to be a biomarker for predicting POCD after open-heart surgery.
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2. Johansson M. Cognitive impairment and its consequences in everyday life: experiences of people with mild cognitive impairment or mild dementia. Int Psychogeriatr 2015;27:949-58.
3. Ronawulan E. Penentuan validasi dan nilai normal uji neurokognitif. MA Thesis, Universitas Indonesia, Jakarta; 2004.
4. Soenarto RF, Mansjoer A, Amir N, Aprianti M, Perdana A. Cardiopulmonary bypass alone does not cause postoperative cognitive dysfunction following open-heart surgery. Anesth Pain Med 2018;8:e83610.
5. Tomaszewski D. Biomarkers of brain damage and postoperative cognitive disorders in orthopedic patients: an update. Biomed Res Int 2015. DOI:10.1155/2015/402959
6. Steidl S. The adverse effects of the cardiopulmonary bypass machine. Senior Honors Thesis, Liberty University, Virginia; 2011.
7. Vallet B, Robin E, Lebuffe G. Venous oxygen saturation as a physiologic transfusion trigger. Crit Care Lond Engl 2010;14:213.
8. Ni C, Xu T, Li N, Tian Y, Han Y, Xue Q, et al. Cerebral oxygen saturation after multiple perioperative influential factors predicts the occurrence of postoperative cognitive dysfunction. BMC Anesthesiol 2015;15:156.
9. Hajdukova L, Sobek O, Prchalova D, Bílkova Z, Koudelkova M, Lukaskova J, et al. Biomarkers of brain damage: S100B and NSE concentrations in cerebrospinal fluid—a normative study. BioMed Res Intl 2015. https://doi.org/10.1155/2015/379071
10. Yardan T, Erenler AK, Baydin A, Aydin K, Cokluk C. Usefulness of S100B protein in neurological disorders. J Pak Med Assoc 2011;61:276–81.
11. Goyal A, Failla MD, Niyonkuru C, Amin K, Fabio A, Berger RP, et al. S100B as a prognostic biomarker in outcome prediction for patients with severe traumatic brain injury. J Neurotrauma 2013;30:946–57.
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