DRUG RELEASE CONTROL AND ENHANCEMENT USING CARRIERS WITH DIFFERENT CONCENTRATIONS OF CAPMUL® MCM C8
DOI:
https://doi.org/10.22159/ijap.2021v13i1.39742Keywords:
Capmul MCM C8, Drug delivery, Free radical polymerization, Bioavailability enhancementAbstract
Objective: The main aim of this study was to design a drug carrier capable to control and enhance the release of poorly water soluble drugs.
Methods: Three polymeric formulations, based on poly (2-hydroxyethyl methacrylate) and loaded with different Capmul® MCM C8 concentrations (0, 10 and 20 % w/w), were prepared. Felodipine, which is a poorly soluble substance, was selected as a model drug. The effect of Capmul® MCM C8 on swelling behavior and in vitro release profile of the prepared polymer was investigated in PBS.
Results: The swelling profiles of allformulationswere statistically similar, which indicated the non-significant effect of added Capmul® MCM C8 on polymer's swelling behavior. All formulations showed a delayed drug release. Formulation-F3, which is loaded with 20% w/wCapmul® MCM C8 displayed a significant higher release compared to the other formulations.
Conclusion: Capmul® MCM products, which are widely used in food industries, can be used to improve the oral delivery of poorly soluble substances. The optimized formulation exhibited the ability to control and enhance the release of the model drug.
Downloads
References
Sareen S, Mathew G, Joseph L. Improvement in solubility of poor water-soluble drugs by solid dispersion. Int J Pharm Invest 2012;2:12-7.
Bremmell K,PrestidgeC. Enhancing oral bioavailability of poorly soluble drugs with mesoporous silica based systems: opportunities and challenges. Drug DevInd Pharm 2019;45:349-58.
Cid A, Simonazzi A, Palma S,Bermudez J. Solid dispersion technology as a strategy to improve the bioavailability of poorly soluble drugs. Ther Delivery 2019;10:363-82.
Zhou Y, Du J, Wang L,Wang Y. Nanocrystals technology for improving bioavailability of poorly soluble drugs: a mini-review. J NanosciNanotechnol 2017;17:18-28.
Aloisio C, Antimisiaris S, Longhi M. Liposomes containing cyclodextrins or meglumine to solubilize and improve the bioavailability of poorly soluble drugs. J Mol Liquids 2017;229:106-13.
Abuzar S, Hyun S, Kim J, Park H, Kim M, Park J,et al. Enhancing the solubility and bioavailability of poorly water-soluble drugs using supercritical antisolvent (SAS) process. Int J Pharm 2018;538:1-13.
Potphode V, Deshmukh A,Mahajan V. Self-micro emulsifying drug delivery system: an approach for enhancement of bioavailability of poorly water soluble drugs. Asian J Pharm Technol 2016;6:159-68.
Repka M, Bandari S, Kallakunta V, Vo A, McFall H, Pimparade M,et al. Melt extrusion with poorly soluble drugs–an integrated review. IntJPharm 2018;535:68-85.
Li S, Madan P,Lin S. Effect of ionization of drug on drug solubilization in SMEDDS prepared using capmul MCM and caprylic acid. Asian JPharm Sci2017;12:73-82.
Lee Y, Dalton C, Regler B,Harris D. Drug solubility in fatty acids as a formulation design approach for lipid-based formulations: a technical note. Drug Dev Industrial Pharm 2018;44:1551-6.
Efiana N, Dizdarevic A, Huck C,BernkopSchnürch A. Improved intestinal mucus permeation of vancomycin via incorporation into nanocarrier containing papain-palmitate. JPharm Sci2019;108:3329-39.
Shailendrakumar A, Ghate V, Kinra M, Lewis S.Improved oral pharmacokinetics of pentoxifylline with palm oil and Capmul® MCM containing self-nano-emulsifying drug delivery system. AAPS PharmSciTech 2020;21:1-12.
Meola T, Schultz H, Peressin K, Prestidge C. Enhancing the oral bioavailability of simvastatin with silica-lipid hybrid particles: the effect of supersaturation and silica geometry. Eur J Pharm Sci 2020;150:1053-7.
Tran N, Yang M. The ophthalmic performance of hydrogel contact lenses loaded with silicone nanoparticles. Polymers 2020;12:1128.
Ozay O, Ilgin P, Ozay H, Gungor Z, Yilmaz B, Kıvanç M. The preparation of various shapes and porosities of hydroxyethyl starch/p (HEMA-co-NVP) IPN hydrogels as programmable carrier for drug delivery. J Macromolecular Sci Part A 2020;57:379-87.
GylesD, Castro L, Silva Jr J, RibeiroCosta R. A review of the designs and prominent biomedical advances of natural and synthetic hydrogel formulations. Euro Polymer J 2017;88:373-92.
Karabanova L, Mikhalovsky S,Lloyd A. Gradient semi-interpenetrating polymer networks based on polyurethane and poly (2-hydroxyethyl methacrylate) for biomedical applications. J Materials Chem 2012;22:7919-28.
Bayan M, Bayan R. Recent advances in mesalamine colonic delivery systems. Future J Pharm Sci 2020;6:1-7.
Pradhan A, Rana P,Sahoo P. Biodegradability and swelling capacity of kaolin based chitosan-g-PHEMA nanocomposite hydrogel. IntJBiol Macromolecules 2015;74:620-6.
Ozay O, Ilgin P, Ozay H, Gungor Z, Yilmaz B,Kıvanç M. The preparation of various shapes and porosities of hydroxyethyl starch/p (HEMA-co-NVP) IPN hydrogels as programmable carrier for drug delivery. J Macromolecular Sci Part A 2020;57:379-87.
Mangiacotte N, ProsperiPorta G, Liu L, Dodd M, Sheardown H. Mucoadhesivenanoparticles for drug delivery to the anterior eye. Nanomaterials 2020;10:1400.
Rashid Z, Ranjha N, Rashid F, Raza H. Pharmacokinetic evaluation of microgels for targeted and sustained delivery of acid labile active pharmaceutical agent in animal model. J Drug Delivery SciTechnol 2020;57:101770.
Stegemann S, Leveiller F, Franchi D, De Jong H, Linden H. When poor solubility becomes an issue: from early stage to proof of concept. EurJPharm Sci2007;31:249-61.
Palazi E, Karavas E, Barmpalexis P, Kostoglou M, Nanaki S, Christodoulou E,et al. Melt extrusion process for adjusting drug release of poorly water soluble drug felodipine using different polymer matrices. Eur J Pharm Sci 2018;114:332-45.
Jing B, Wang Z, Yang R, Zheng X, Zhao J, Tang S,et al. Enhanced oral bioavailability of felodipine by novel solid self-microemulsifying tablets. Drug DevInd Pharm 2016;42:506-12.
Shah U, Joshi G,Sawant K. Improvement in antihypertensive and antianginal effects of felodipine by enhanced absorption from PLGA nanoparticles optimized by factorial design. Mater SciEng 2014;35:153-63.
Wu C, Zhao Z, Zhao Y, Hao Y, Liu Y,Liu C. Preparation of a push–pull osmotic pump of felodipine solubilized by mesoporous silica nanoparticles with a core–shell structure. IntJPharm 2014;475:298-305.
Obaidat R, Tashtoush B, Bayan M, Al Bustami R,Alnaief M. Drying using supercritical fluid technology as a potential method for preparation of chitosan aerogel microparticles. AAPS PharmSciTech 2015;16:1235-44.
Patel H, Pandey N, Patel B, Ranch K, Bodiwala K, Vyas B. Enhancement of in vivo hypoglycemic effect of gliclazide by developing self-microemulsifying pellet dosage form. Future J Pharm Sci 2020;6:1-14.
Tran N,Yang M. Synthesis and characterization of silicone contact lenses based on TRIS-DMA-NVP-HEMA hydrogels. Polymers 2019;11:944.
Ferrell W, Kushner D,Hickner M. Investigation of polymer–solvent interactions in poly (styrene sulfonate) thin films. J PolymSci Part B: PolymPhys 2017;55:1365-72.
Mohanrao B, Sundar P,Nagsen S. Oral bioavailability enhancement of a poor water soluble drug by cosurfactant free self-emulsifying drug delivery system (SEDDS). Res J Pharm Technol 2011;4:1557-62.
Alhasani K, Kazi M, Ibrahim M, Shahba A,Alanazi F. Self-nanoemulsifyingramipril tablets: a novel delivery system for the enhancement of drug dissolution and stability. Int J Nanomed 2019;14:5435.
Uchida T, Toida Y, Sakakibara S, Miyanaga Y, Tanaka H, Nishikata M, et al. Preparation and characterization of insulin-loaded acrylic hydrogels containing absorption enhancers. Chem Pharm Bull 2001;49:1261-6.
Onoyima C, Okibe F,Sholadoye Q. Kinetics and mechanisms of doxorubicin release from hydroxyapatite-sodium alginate nanocomposite. Nigerian J Pharm ApplSci Res 2020;9:7-13.
Sharma P,Tailang M. Design, optimization, and evaluation of hydrogel of primaquine loaded nanoemulsion for malaria therapy. Future J Pharm Sci2020;6:1-11.
Li J, Mooney D. Designing hydrogels for controlled drug delivery. Nat Rev Mater2016;1:1-17.
Hamedi S, Koosha M. Designing a pH-responsive drug delivery system for the release of black-carrot anthocyanins loaded in halloysite nanotubes for cancer treatment. Appl Clay Sci2020;197:105770.
Rezaei A,Nasirpour A. Evaluation of release kinetics and mechanisms of curcumin and curcumin-β-cyclodextrin inclusion complex incorporated in electrospun almond gum/PVA nanofibers in simulated saliva and simulated gastrointestinal conditions. BioNanoScience2019;9:438-45.
Raj S, Chandrasekhar K, Reddy K. Formulation, in vitro and in vivo pharmacokinetic evaluation of simvastatin nanostructured lipid carrier loaded transdermal drug delivery system. Future J Pharm Sci2019;5:1-14.
Quintanilla de Stefano J, AbundisCorrea V, Herrera Flores S, Alvarez A. pH-sensitive starch-based hydrogels: synthesis and effect of molecular components on drug release behavior. Polymers 2020;12:1974.
Gupta P,Purwar R. Electrospun pH responsive poly (acrylic acid-co-acrylamide) hydrogel nanofibrous mats for drug delivery. J Polymer Res 2020;27:1-10.
Sharma P, Mittal H, Jindal R, Jindal D,Alhassan S. Sustained delivery of atenolol drug using gum dammar crosslinked polyacrylamide and zirconium based biodegradable hydrogel composites. Colloids Surf A 2019;562:136-45.
