• AHMED M. AGIBA Formulation Department, Research and Development Directorate, IDI Pharmaceutical, East of Al Tafreah, Port Said Governorate, Egypt, Pharmaceutics Department, Faculty of Pharmacy, Sinai University Kantara Campus, Ismailia, Egypt
  • SOHA SAYED ABUL-ELLA Pharmaceutics Department, College of Pharmaceutical Sciences and Industrial Pharmacy, Misr University for Science and Technology, 6th of October City, Egypt
  • REHAB A. ABD EL-MONEM Industrial Pharmacy Department, College of Pharmaceutical Sciences and Industrial Pharmacy, Misr University for Science and Technology, 6th of October City, Egypt



Fixed-dose combination formulations, Multilayered tablets, Novel approaches, Manufacturing improvement, Process parameters, Characterization tests


Fixed-dose combination formulations are multilayered platforms designed for solving complex medication regimens and overcoming polypharmacy problems especially in chronic diseases with geriatric patients. Multilayered tablets are considered promising avenues to combine different active pharmaceutical ingredients (APIs) for a synergic therapeutic effect, or different formulations of the same API in order to achieve a specific drug release profile. Besides, multilayered tablets can extensively help in avoiding possible interactions between different drugs, as well as optimizing each formulation individually in terms of pharmacokinetics and manufacturability. This review article discusses the most suitable materials used in the manufacturing of multilayered tablets, describes novel approaches to manufacturing improvement and process parameters, the influence of process parameters on layer adhesion, and the characterization tests of multilayered tablets.


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Author Biography

AHMED M. AGIBA, Formulation Department, Research and Development Directorate, IDI Pharmaceutical, East of Al Tafreah, Port Said Governorate, Egypt, Pharmaceutics Department, Faculty of Pharmacy, Sinai University Kantara Campus, Ismailia, Egypt

Agiba, A.M. has a bachelor's degree in pharmaceutical sciences and industrial pharmacy from Misr University for Science and Technology (Egypt) with a general grade of Excellent First-Class Honors, a master of pharmaceutical sciences with a specialization in pharmaceutics from Ain Shams University (Egypt), and a master of science in biotechnology from University of Chemical Technology and Metallurgy (Bulgaria) and University of Oviedo (Spain) with a general grade of Excellent (Erasmus Mundus Scholarship).

Agiba, A.M. was granted two research fellowships: Joint NAM S&T Centre ICCBS Research Fellowship at ICCBS, University of Karachi (Pakistan) and FCT Research Grant at CICECO Aveiro Institute of Materials (Portugal), plus an internship at Bajcsy-Zsilinszky Krhz s Rendelintzet (Hungary).

Agiba, A.M has worked for top leading pharmaceutical industries in the Middle East, Africa, and worldwide: SIGMA Pharmaceutical Industries as a product development senior specialist at Formulation R&D, Egyptian Armed Forces Pharmaceutical Factory as a principal researcher, Pharco-B International, a member of Pharco Corporation, as a R&D section head at Formulation R&D, and October Pharma as R&D section head at Formulation R&D.  

Agiba, A.M has 6 international research/review articles in high-quality, peer-review journals, 8 international conference papers and 2 theses.


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