FORMULATION AND EVALUATION OF SUSTAINED-RELEASE PELLETS OF LORNOXICAM

MILIND J. AMIN; KEYUR S. PATEL; DEEPA R. PATEL; ZIL P. PATEL; JAYANTI V. BAJAG

doi:10.22159/ijap.2021v13i4.41601

Authors

MILIND J. AMIN K. B. Raval College of Pharmacy, Shertha, Gandhinagar 382423, Gujarat, India
KEYUR S. PATEL Kalol Institute of Pharmacy, Kalol, Gandhinagar 382721, Gujarat, India
DEEPA R. PATEL Kalol Institute of Pharmacy, Kalol, Gandhinagar 382721, Gujarat, India
ZIL P. PATEL Kalol Institute of Pharmacy, Kalol, Gandhinagar 382721, Gujarat, India
JAYANTI V. BAJAG School of Pharmacy, Rai University, Dholka, Ahmedabad 382260, Gujarat, India

DOI:

https://doi.org/10.22159/ijap.2021v13i4.41601

Keywords:

Lornoxicam, Sustained release pellets, Eudragit, RLPO, Eudragit RSPO

Abstract

Objective: The aim of the study was to develop sustained release pellets of lornoxicam using Eudragit RLPO and Eudragit RSPO to reduce the dosing frequency.

Methods: The sustained release pellets of lornoxicam were prepared by extrusion–spheronization technique using Eudragit RLPO and Eudragit RSPO as release retardant polymers and microcrystalline cellulose as spheronizing agent. A 3² Full factorial design was applied to investigate the combined effect of the two independent variables i.e. concentration of Eudragit RLPO (X₁) and concentration of Eudragit RSPO (X₂) on the dependent variables, In vitro drug release at 1h (Y₁), In vitro drug release at 4 h (Y₂) and In vitro drug release at 12 h. (Y₃).

Results: The optimized formulation (F0) show in vitro drug release 11.24±1.21 %, 43.69±1.28 %, 82.69±1.74 % and 100.24±1.56 % at 1 h, 4 h, 12 h and 24 h respectively. Drug excipients compatibility study by FTIR showed no interaction between drug and excipients. Eudragit RLPO and Eudragit RSPO had a significant effect on in vitro drug release.

Conclusion: From all parameters and experimental design evaluation, it was concluded that the drug release rate decreased with an increase the concentration of Eudragit RLPO and Eudragit RSPO. SEM Photomicrograph of pellets revealed that the surface was rough and the pellets were spherical shaped in nature. The in vitro release kinetics revealed higuchi model is followed and drug release is by anamolous diffusion.

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