PRELIMINARY STUDY ON THE IMPACT OF POLYMER-LIPID TYPES AND RATIO TO POLYMERIC-LIPID HYBRID NANOPARTICLE
DOI:
https://doi.org/10.22159/ijap.2021v13i4.41663Keywords:
Polymeric-lipid hybrid nanoparticle, Egg phosphatidylcholine, Lecithin, Na alginate, ChitosanAbstract
Objective: This study aims to determine the best lipid to polymer ratios in polymeric-lipid nanoparticles using various types and ratios of polymers and lipids.
Method: Polymeric-lipid nanoparticle was prepared using the modified one-step nanoprecipitation method. This study used chitosan and Na alginate as polymers and lecithin and egg phosphatidylcholine as lipids. The lipid was crossed-combined with polymer in various ratios, i. e 12.5%, 25.0%, and 37.5%. On its preparation, Cinnamomum burmanii extract was loaded into the resulted polymeric-lipid nanoparticle as an active substance model. The results were assessed its particle surface characteristics including particle size, polydispersity index, and zeta potential.
Results: Twelve formulas resulted from crossed-combination between the lipid and polymer were used in this study. Polymeric-lipid nanoparticles resulted from the combination of egg phosphatidylcholine/Na alginate has particle size, polydispersity index, and zeta potential of 380.07±3.52 nm, 0.66±002, and-30.6±1.15 mV, respectively.
Conclusions: The best lipid to polymer ratio and type was observed in egg phosphatidylcholine: Na alginate. The particle surface characteristics were better compared to other combinations.
Downloads
References
Zhang L, Zhang L. Lipid-polymer hybrid nanoparticles: synthesis, characterization and application. Nano Life 2010;1:73-163.
Zhang L, Chan JM, Gu FX, Rhee J, Wang AZ, Radovic Moreno AF, et al. Self-assembled lipid−polymer hybrid nanoparticles a robust drug delivery platform. ACS Nano 2008;2:702-1696.
Enlow EM, Luft JC, Napier ME, Desimone JM. Potent engineered PLGA nanoparticles by virtue of exceptionally high chemotherapeutic loadings. Nano Lett 2011;11:13-808.
Albanese A, Tang PS, Chan WCW. The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu Rev Biomed Eng 2012;14:1–16.
Sharma A, Sharma US. Liposomes in drug delivery: Progress and limitations. Int J Pharm 1997;154:40-123.
Bonde S, Nair S. Advances in liposomal drug delivery system: Fascinating types and potential applications. Int J Appl Pharm 2017;9:1–7.
Otsuka H, Nagasaki Y, Kataoka K. PEGylated nanoparticles for biological and pharmaceutical applications. Adv Drug Delivery Rev 2003;55:19-403.
Sheng Y, Liu C, Yuan Y, Tao X, Yang F, Shan X, et al. long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan. Biomaterials 2009;30:2340.
Kandel PK, Fernando LP, Ackroyd PC, Christensen KA. Incorporating functionalized polyethylene glycol lipids into reprecipitated conjugated polymer nanoparticles for bioconjugation and targeted labeling of cells. Nanoscale 2011;3:45-1037.
Zhang L, Chan JM, Gu FX, Rhee JW, Wang AZ, Radovic Moreno AF, et al. Self-assembled lipid-polymer hybrid nanoparticles: a robust drug delivery platform. ACS Nano 2008;2:702-1696.
Panyam J, Labhasetwar V. B iodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Delivery Rev 2003;55:47-329.
Govender T, Stolnik S, Garnett MC, Illum L, Davis SS. PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water-soluble drug. J Controlled Release 1999;57:171–85.
Dinesh KV, Verma PRP, Singh SK. Development and evaluation of biodegradable polymeric nanoparticles for the effective delivery of quercetin using a quality by design approach. Food Sci Technol 2015;61:8-330.
Yu K, Zhao J, Yu C, Sun F, Liu Y, Zhang Y, et al. Role of four different kinds of polyethyleneimine (PEIs) in preparation of polymeric lipid nanoparticles and their anticancer activity study. J Cancer 2016;7:82-872.
Hadinoto K, Sundaresan A, Cheow WS. Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: a review. Eur J Pharm Biopharm 2013;85:43-427.
Sivapriya V, Ponnarmadha S, Azeezand NA, Sudarshanadeepa V. Novel nanocarriers for ethnopharmacological formulations. Int J Appl Pharm 2018;10:26–30.
Torchilin VP. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discovery 2005;4:60-145.
Maurer N, Fenske DB, Cullis PR. Developments in liposomal drug delivery systems. Expert Opin Biol Ther 2001;1:47-923.
Yang XZ, Dou S, Wang YC, Long HY, Xiong MH, Mao CQ, et al. Single-step assembly of cationic lipid-polymer hybrid nanoparticles for systemic delivery of siRNA. ACS Nano 2012;6:65-4955.
Anderson RA. Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc Nutr Soc 2008;67:48–53.
Li J, Cai C, Sun T, Wang L, Wu H, Yu G. Chitosan-based nanomaterials for drug delivery. Molecules 2018;23:1–26.
Ahmadi F, Oveisi Z, Samani SM, Amoozgar Z. Chitosan-based hydrogels: characteristics and pharmaceutical applications. Res Pharm Sci 2015;10:1–16.
Chan JM, Zhang L, Yuet KP, Liao G, Rhee JW, Langer R, et al. PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery. Biomaterials 2009;30:34-1627.
Published
How to Cite
Issue
Section
