OPTIMIZATION OF STARCH GLYCOLATE AS NOVEL SUPERDISINTEGRANT IN THE FORMULATION OF GLIPIZIDE FAST DISSOLVING TABLETS THROUGH 23FACTORIAL DESIGN

A. HARI OM PRAKASH RAO; R. SANTOSH KUMAR; SHAMBHAVI KANDUKURI; M. RAMYA

doi:10.22159/ijap.2021v13i5.41940

Authors

A. HARI OM PRAKASH RAO GITAM Institute of Pharmacy, GITAM (Deemed to be University) Rushikonda, Vishakhapatnam, A. P. 530045, India
R. SANTOSH KUMAR GITAM Institute of Pharmacy, GITAM (Deemed to be University) Rushikonda, Vishakhapatnam, A. P. 530045, India
SHAMBHAVI KANDUKURI GITAM Institute of Pharmacy, GITAM (Deemed to be University) Rushikonda, Vishakhapatnam, A. P. 530045, India
M. RAMYA GITAM Institute of Pharmacy, GITAM (Deemed to be University) Rushikonda, Vishakhapatnam, A. P. 530045, India

DOI:

https://doi.org/10.22159/ijap.2021v13i5.41940

Keywords:

Optimized, Superdisintegrant, Fast dissolving, Optimization, Starch glycolate

Abstract

Objective: To synthesize, characterize and evaluate starch glycolate as a superdisintegrant in the formulation of Glipizide fast dissolving tablets by employing 2³ factorial designs.

Methods: Starch glycolate was prepared and its physical and micromeritic properties were performed to evaluate it. The fast dissolving tablet of Glipizide was prepared by employing starch crotonate as a superdisintegrant in different proportions in each case by direct compression method using 2³ factorial design for the evaluation of tablet parameters like disintegration and dissolution efficiency in 5 min.

Results: The starch glycolate prepared was found to be fine, free-flowing and amorphous. Starch glycolate exhibited good swelling in water with a swelling index (10%). The study of starch glycolate was shown by fourier transform infrared spectra (FTIR). The drug content (100±5%), hardness (3.5–4 kg/sq. cm), and friability (<0.15%) was been effective with regard to all the formulated fast dissolving tablets employing starch glycolate. The disintegration time of all the formulated tablets was found to be in the range of 13±0.015 to 180±0.014 sec. The optimized formulation F8 had the least disintegration time i.e., 13±0.015 sec. The wetting time of the tablets was found to be in the range of 8±0.015 to 95±0.013 sec. The In vitro wetting time was less (i.e., 8±0.015s) in optimized formulation F8. The water absorption ratio of the formulated tablets was found to be in the range of 75±0.012 to 150±0.014%. The percent drug dissolved in the optimized formulation F8 was found to be 99.95% in 5 min.

Conclusion: Starch glycolate was an efficient superdisintegrant for fast-dissolving tablets. The disintegration and dissolution efficiency of the fast dissolving tablets of glipizide was good and depended on the concentration of superdisintegrant employed i.e., starch glycolate, sodium starch glycolate, crospovidone. The formulated fast dissolving tablets of glipizide exhibited good dissolution efficiency in 5 min which can be used for the fast therapeutic action of glipizide.

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