FORMULATION AND EVALUATION OF WOUND HEALING GEL OF WHITE LEADTREE (LEUCAENA LEUCOCEPHALA (LAM.) DE WIT.) LEAVES EXTRACT

EVY FENNY VERONICA; RINI DWIASTUTI

doi:10.22159/ijap.2022v14i1.42126

Authors

EVY FENNY VERONICA Faculty of Pharmacy, Sanata Dharma University, Yogyakarta, Indonesia
RINI DWIASTUTI Faculty of Pharmacy, Sanata Dharma University, Yogyakarta, Indonesia

DOI:

https://doi.org/10.22159/ijap.2022v14i1.42126

Keywords:

Leucaena leaves, Gel, Wound healing, Gelling agent, Humectant

Abstract

Objective: The aim of this research is to formulate and evaluate the wound healing gel of Leucaena leucocephala leaves extract.

Methods: In this research, the extract of Leucaena leaves was formulated into wound healing gel by using a variation of the concentration of Carbopol as a gelling agent and Propylene glycol as a humectant. Afterward, the gel's physical properties (pH, viscosity, spreadability), stability, and sterility were tested. The wound healing activity was evaluated by making excision wounds on the Wistar Albino rat's back, and then the gels were applied to the wound every day. The wound's size was measured and counted as the percentage of wound closure.

Results: The result showed that Formula 4 (contains 1.5% of Carbopol and 12% of Propylene glycol) has the best physical characteristics and wound healing activity. Formula 4 showed 100% wound closure on the 11^th day of the treatment, while the negative control only reached 49.12%. The statistical parameter with the p-value<0.05 stated that they are significantly different.

Conclusion: This research demonstrated that gel with Leucaena leaf extract has good physical characteristics, and it can significantly improve the wound healing process.

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