DEVELOPMENT AND PHARMACOKINETICS OF CURCUMIN LOADED BETA CAROTENE NANOPARTICLES IN RATS

Authors

  • RAVIKANTH CHINTHALA Department of Pharmacy, University College of Technology, Osmania University, Hyderabad 500007, Telangana, India
  • SURYA SATYANARAYANA SINGH Department of Biochemistry, University College of Science, Osmania University, Hyderabad 500007, Telangana, India

DOI:

https://doi.org/10.22159/ijap.2021v13i5.42339

Keywords:

Bio-availability, Curcumin, Beta carotene, Area under the curve, Overall elimination rate constant

Abstract

Objective: The main objective of this research work is to improve the bioavailability of curcumin using beta carotene nanoparticles in experimental animals.

Methods: Curcumin-loaded beta carotene nanoparticles (NPs) have been prepared by emulsion–diffusion–evaporation method. Beta carotene and ethyl acetate were used to formulate NPs, and poly (vinyl alcohol) was used as a stabilizer. The emulsion diffusion evaporation method was used to prepare the nanoparticles and bioavailability and various pharmacokinetic parameters were compared with curcumin suspension in rats.

Results: The nanoparticles were successfully prepared using beta carotene and curcumin and the drug loading was almost 93% of the initial weight. Particle sizes were below 200 nm with negative zeta potentials. Comparing the pharmacokinetic parameters of curcumin loaded nanoparticles (Cmax, Tmax, Kel, and AUC were 105 µg/ml, 2 h, 0.23/h, and 1629 µg.hr/ml) with pure curcumin (Cmax, Tmax, Kel and AUC 16 µg/ml, 1h, 0.275/h and 58 µg.hr/ml) indicated a drastic improvement in bioavailability of curcumin.

Conclusion: The relative bioavailability was almost increased 30 times with beta carotene nanoparticles.

Downloads

Download data is not yet available.

References

Nayak AK, Ahmad SA, Beg S, Ara TJ, Hasnain MS. Drug delivery: present, past, and future of medicine. In: Inamuddin, Asiri AM, Mohammad A. (eds) Applications of nanocomposite materials in drug delivery. Woodhead Publishing Series in Biomaterials, Elsevier Inc; 2018. p. 255–82.

Ahmad R, Srivastava S, Ghosh S, Khare SK. Phytochemical delivery through nanocarriers: a review. Colloid Surface B 2021;197:111389.

Devadasu VR, Bhardwaj V, Kumar MR. Can controversial nanotechnology promise drug delivery? Chem Rev 2013;113:1686-735.

Marinoa T, Casellab P, Sangiorgioc P, Verardic A, Ferrarod A, Hristoforoud E, et al. Natural beta-carotene: a microalgae derivate for nutraceutical applications. Chem Eng 2020;79:1.

Sharifi Rad J, Rayess YE, Rizk AA, Sadaka C, Zgheib R, Zam W, et al. Turmeric and its major compound curcumin on health: bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications. Front Pharmacol 202;11:1021.

Devadasu VR, Wadsworth RM, Kumar MR. Protective effects of nanoparticulate coenzyme Q 10 and curcumin on inflammatory markers and lipid metabolism in streptozotocin-induced diabetic rats: a possible remedy to diabetic complications. Drug Delivery Transl Res 2011;1:448-55.

Shaikh J, Ankola DD, Beniwal V, Singh D, Kumar MR. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci 2009;37:223-30.

Rapalli VK, Kaul V, Gorantla S, Waghule T, Dubey SK, Pandey MM, et al. UV Spectrophotometric method for characterization of curcumin loaded nanostructured lipid nanocarriers in simulated conditions: method development, in vitro and ex-vivo applications in topical delivery. Spectrochim Acta Part A 2020;224:117392.

Lala RR, Shinde AS, Nandvikar NY. Solid lipid nanoparticles: a promising approach for combinational drug therapy in cancer. Int J Appl Pharm 2018;10:17-22.

Jogala SA, Chinnala KM, Aukunuru JI. Novel subcutaneous sustained release nanoparticles encapsulating low molecular weight heparin (LMWH): preparation, characterization and evaluation. Int J Pharm Pharm Sci 2016;8:264-8.

Gupta M. Synergistic anti-cancer effects of natural products and their mode of action. Asian J Pharm Clin Res 2021;14:15-21.

Shelat PR, Mandowara VK, Gupta DG, Patel SH. Formulation of curcuminoid loaded solid lipid nanoparticles in order to improve oral bioavailability. Int J Pharm Pharm Sci 2015;7:278-82.

Sapavatu SN, Chinthala R, Jadi RK. An overview on pharmacokinetics of polymeric nanoparticles intended for oral delivery. J Young Pharm 2020;12:187-9.

Published

07-09-2021

How to Cite

CHINTHALA, R., & SINGH, S. S. (2021). DEVELOPMENT AND PHARMACOKINETICS OF CURCUMIN LOADED BETA CAROTENE NANOPARTICLES IN RATS. International Journal of Applied Pharmaceutics, 13(5), 172–176. https://doi.org/10.22159/ijap.2021v13i5.42339

Issue

Section

Original Article(s)