FORMULATION OF EFFERVESCENT GRANULES FROM RED GINGER (ZINGIBERIS OFFICINALE ROSCOE VAR. RUBRUM) EXTRACT AND ITS ANTIOXIDANT ACTIVITY

DIAH LIA AULIFA; DIKI PRAYUGO WIBOWO; NENI SAFITRI; ARIF BUDIMAN

doi:10.22159/ijap.2022v14i1.43377

Authors

DIAH LIA AULIFA Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran
DIKI PRAYUGO WIBOWO Department of Pharmaceutical Biology, Indonesian School of Pharmacy (Sekolah Tinggi Farmasi Indonesia), JI Soekarno Hatta no.354, Bandung, Indonesia https://orcid.org/0000-0002-2659-8288
NENI SAFITRI Department of Pharmaceutical Biology, Indonesian School of Pharmacy (Sekolah Tinggi Farmasi Indonesia), JI Soekarno Hatta no.354, Bandung, Indonesia
ARIF BUDIMAN Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran

DOI:

https://doi.org/10.22159/ijap.2022v14i1.43377

Keywords:

Red ginger, Effervescent granules, Antioxidant, Flowability

Abstract

Objective: Ginger is one of the Indonesian plants that has been used as traditional medicine. The flavonoids and phenols compounds contained high antioxidant activity. This study aimed to formulate effervescent granules (EG) from red ginger (RG) extract and evaluate its antioxidant activity.

Methods: The formulation of EG from RG extract was prepared by the wet granulation method using different concentrations of polyvinylpyrrolidone (PVP). Furthermore, the flowability of granules was evaluated, including flow rate, angle of repose, bulk density, tapped density, Carr's index, Hausner ratio, and effervescent time. The physical stability of granules such as organoleptic evaluation, effervescent time, and pH measurement was also evaluated after 28 d of storage, and the antioxidant activity of EG from RG extract was determined using 1,1-diphenyl-2-picrylhydrazyl (DPPH).

Results: The result showed that the EG of RG extract was successfully prepared by wet granulation with a concentration of 15%. In addition, the flowability study showed that all formulas of EG from RG extract have good flow properties, and the granules showed excellent flow properties based on Carr′s index results. The effervescent time of granules remained within the acceptable range according to USP, and the physical stability did not change even after 28 d of storage. The IC₅₀of EG from RG extract was 283.28±3.6 ppm and has moderate in free radicals scavenging activity.

Conclusion: EG from RG extract can be used as food supplements to protect the human body from free radicals and inhibit oxidases.

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