CIRCADIAN RHYTHMS REGULATED ASTHMA TREATMENT BY VIRTUE OF PULSATILE DRUG DELIVERY SYSTEM

SAHIL KHAN; MONIKA

doi:10.22159/ijap.2022v14i4.44395

Authors

SAHIL KHAN Department of Pharmaceutics, Noida Institute of Engineering and Technology, (Pharmacy Institute) Affiliated to DR. A. P. J. Abdul Kalam Technical University, 19, Institutional Area, Knowledge Park, Uttar Pradesh 201306
MONIKA Department of Pharmaceutics, Noida Institute of Engineering and Technology, (Pharmacy Institute) Affiliated to DR. A. P. J. Abdul Kalam Technical University, 19, Institutional Area, Knowledge Park, Uttar Pradesh 201306

DOI:

https://doi.org/10.22159/ijap.2022v14i4.44395

Keywords:

Asthma, Pulsatile drug delivery system (PDDS), Circadian rhythm, Chronotherapeutic

Abstract

Asthma, as we all know, is a disease that shows a high tendency of chronic inflammation in the airways, which associates with airflow obstruction. Lung function seems to be decreased in the case of people suffering from asthma. On reviewing many studies from the past, clear statements come out which also revealed that asthma is based on established circadian rhythm. Asthma is considered to be one of the diseases which affects majorly common in adult women than in men; according to numerous studies, 42 percent of persons with active asthma claimed that their asthma started before they were 16 y old. The pulsatile drug delivery system, an innovation in pharmaceutical technology, is generating huge attention these days and is alleged to be the most productive in the treatment of asthma as per many studies. Many pulsatile delivery system components, such as the osmotic system, capsular system, and single and multiple-unit system, are utilized to diagnose and treat diseases caused by biological rhythm disturbances. Various emerging diseases such as cardiovascular, peptic ulcer, asthma, peptic ulcer, diabetes mellitus, cancer, and hypercholesterolemia have been examined by fluctuation in biological rhythms and treated by a pulsatile drug delivery system. During this era, the pulsatile drug delivery system delivers the medicine at the right time duration, in the right place, and the right proportion and the effectiveness of pulsatile drug delivery on asthma have indeed been investigated in this article.

Downloads

Download data is not yet available.

References

Lodhi DS, Panwar AS, Golani P, Verma M. A review of the combination of xanthine and bronchodilator drug in mouth dissolving film for asthma treatment. Structure. 2021 Oct;4:5.

Gourineni R, Zee PC. Neurological and medical disorders associated with circadian rhythm disturbances. In: sleep: a comprehensive handbook. Hoboken, nj. usa: john wiley & sons, inc; 2005 Nov 4. p. 401-7.

Martin RJ. Nocturnal asthma: circadian rhythms and therapeutic interventions. Am Rev Respir Dis. 1993 Jun;147(6 Pt 2):S25-8. doi: 10.1164/ajrccm/147.6_Pt_2.S25, PMID 8494197.

Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. Pulsatile delivery systems: an approach for chronotherapeutic diseases. Syst Rev Pharm. 2010 Jan–Jun;1(1):55. doi: 10.4103/0975-8453.59513.

Paul AD, Divyavani G, Pavani K, Gaffar A, Thyagaraju K. Advanced drug delivery in designing of biological rhythm through pulsatile drug delivery system: current state of art. Indo Am J Pharm Res. 2019 Feb 2;8(1):s.

Jain SS, Agarwal HV, Jagtap PS, Dand NM, Jadhav KR, Kadam VJ. Pulsatile drug delivery system (PDDS): a brief overview. Res J Pharm Technol. 2012 Apr;5(4):449-61.

Jain D, Raturi R, Jain V, Bansal P, Singh R. Recent technologies in pulsatile drug delivery systems. Biomatter. 2011 Jul 1;1(1):57-65. doi: 10.4161/biom.1.1.17717, PMID 23507727.

Bilaskar VV, Patil IS, Patil OA, Mandke GR, Mohite SK. Design, development and optimization of pulsatile drug delivery of antihypertensive drug. Int J Pharm Biol Sci. 2018.

Garg AK, Kumar A, Rani S, Singh M, Sharma A, Kumar R. Formulation and evaluation of chronotherapeutic pulsatile drug delivery system containing rabeprazole sodium. J Appl Pharm Sci. 2017 Feb;7(02):93-100.

Kalantzi LE, Karavas E, Koutris EX, Bikiaris DN. Recent advances in oral pulsatile drug delivery. Recent Pat Drug Deliv Formul. 2009 Jan;3(1):49-63. doi: 10.2174/ 187221109787158337, PMID 19149729.

Shrivastava A. Pulsatile drug delivery systems: a case of beta-blockers. Asian J Pharm Clin Res. 2019 Mar;12(3):16-22. doi: 10.22159/ajpcr.2019.v12i3.29704.

Parmar RD, Parikh RK, G Vidyasagar, Patel DV, Patel CJ, Patel BD. Pulsatile drug delivery systems: an overview. PCI-Approved-IJPSN 2009;2(3):605-14. doi: 10.37285/ ijpsn.2009.2.3.3.

Sinha VR, Kumria R. Binders for colon specific drug delivery: an in vitro evaluation. Int J Pharm. 2002 Dec 5;249(1-2):23-31. doi: 10.1016/s0378-5173(02)00398-8, PMID 12433431.

Singh R, Sharma PK, Malviya R. Circadian cycle and chronotherapeutics: recent trend for the treatment of various biological disorders. Recent Pat Drug Deliv Formul. 2012 Apr 1;6(1):80-91. doi: 10.2174/187221112799219107, PMID 22044257.

Singh A, Dubey H, Shukla I, Singh DP. Pulsatile drug delivery system: an approach of medication according to circadian rhythm. J Appl Pharm Sci. 2012;2(03):166-76.

Sarkhejiya NA, Bhardia PD. Newer insights into pulsatile drug delivery systems. World J Pharm Res. 2017 Jan 27;5(2):134-50.

Jassem NA, Ali SK. A novel pulsatile drug delivery approach–a laconic review. Int J Pharmacol Res. 2020 Jul;12(2). doi:10.31838/ijpr/2020.SP2.576

Awasthi R, Kumar P, Kumar Pawar VK. Chronotherapy: science and technology of drug scheduling on the basis of biological rhythm. J Drug Deliv. 2010;1(1):9-18.

Suresh S, Pathak S. Chronotherapeutics: emerging role of biorhythms in optimizing drug therapy. Indian J Phrm Sci. 2005 Mar;67(2):135-40.

Nagar M, Singhai S, Chopra VS, Gautam N, Trivedi P. Chronotropic systems; an emerging trend in drug delivery for pulsed release in chronopharmacotherapy. Int J Pharm Clin Res. 2010 Jan;2(1):10-9.

Gupta NB. Pulsatile drug delivery as modified release dosage form: a review. J Drug Delivery Ther 2012;2(6):102-10. doi: 10.22270/jddt.v2i6.312.

Maev IV, V’iuchnova ES, Dicheva DT, Lebedeva EG. [Chronotherapy approaches in the treatment of gastroduodenal ulcer]. Klin Med (Mosk). 2002 Jan 1;80(3):46-9. PMID 11980160.

Shanmugan P. Chronotherapeutic drug delivery systems. J Drug Metab Toxicol. 2015 Dec 07;6(5):2. doi: 10.4172/2157-7609.1000194.

Vincenzi B, Santini D, La Cesa A, Tonini G. Cancer chronotherapy: principles, applications, and perspectives. Cancer. 2003 Aug 15;98(4):881-2. doi: 10.1002/cncr.11600, PMID 12910534.

Reddy JR, Jyothsna MV, Saleem TM, Chetty CM. Review on: pulsatile drug delivery systems. J Pharm Sci Res. 2009 Dec 1;1(4):109.

Ravichandiran V, Suba V, Senthilnathan B, Rajachandrika K, Padmapriya S, Saraswathy T. Pulsatile drug delivery system. Biomed Pharmacol J. 2015 Feb 16;2(2):227-34.

Wagh VD, Kalshetti P. Chronopharmaceutics: dosage form design to rhythms in disease state. J Chronother Drug Deliv. 2011;2(1):23-9.

Belgamwar VS, V Gaikwad M, Patil GB, Surana S. Pulsatile drug delivery system. Asian J Pharm. 2008 Jul;2(3). doi: 10.4103/0973-8398.43297.

Maroni A, Zema L, Cerea M, Sangalli ME. Oral pulsatile drug delivery systems. Expert Opin Drug Deliv. 2005 Sep 16;2(5):855-71. doi: 10.1517/17425247.2.5.855, PMID 16296783.

Tajane SR, Kholwal BB, Suryawanshi SS, Tarkase KN. Current trends in pulsatile drug delivery systems. Int J Pharm Sci Res. 2012 Feb 1;3(2):358.

Bharathi A. Chronotherapy: new approach for treatment. World J Pharm Res. 2018;7(7):2114-48.

Survase S, Kumar N. Pulsatile drug delivery: current scenario. Curr Res Pharm Sci. 2007 Apr;8(2):27-33.

Lalwani A, Santani DD. Pulsatile drug delivery systems. Indian J Pharm Sci. 2007;69(4):489. doi: 10.4103/0250-474X.36932.

Vanka E, Rani MJ, Babu AS, Rao PV. An overview on pulsatile drug delivery system. Pharmacia Tutor. 2013 Dec 20;1(2):17-22.

Gupta NB. Pulsatile drug delivery as modified release dosage form: a review. J Drug Delivery Ther. 2012 Nov 11;2(6):102-10. doi: 10.22270/jddt.v2i6.312.

Pandit V, Kumar A, Ashawat MS, Verma CP, Kumar P. Recent advancement and technological aspects of pulsatile drug delivery system- a laconic review. Curr Drug Targets. 2017;18(10):1191-203. doi: 10.2174/1389450117666160208144343, PMID 26853323.

Dalvadi H, Patel JK. Chronpharmaceutics, pulsatile drug delivery system as current trend. Asian J Pharm. 2010 Dec;5(5):204-30.

Bandgar AA, Joshi DG, Kurade DS. Pulsatile drug delivery with press coated techniques. Int J Pharm Res Rev. 2015 Nov;4(11):55-75.

Firoz S, Kothai R, Arul B. Novel approaches for pulsatile drug delivery system. Crit Rev. 2020 Jul;7(13):2282-9.

Nallaguntla L, Venkataswamy R. Review article on pulsatile drug delivery system. Asian J Pharm Clin Res. 2021 Jul 29;14(6):48-59.

Gandhi BR, Mundada AS, Gandhi PP. Chronopharmaceutics: as a clinically relevant drug delivery system. Drug Deliv. 2011 Jan 1;18(1):1-18. doi: 10.3109/10717544.2010.509358, PMID 21138394.

Jain AA. A review on: pulsatile drug delivery system. World J Pharm Res. 2017;6(11):342-57. doi: 10.20959/wjpr201711-9610.

Kikuchi A, Okano T. Pulsatile drug release control using hydrogels. Adv Drug Deliv Rev. 2002 Jan 17;54(1):53-77. doi: 10.1016/s0169-409x(01)00243-5, PMID 11755706.

Singh DK, Poddar AS, Nigade SU, Poddar SS. Pulsatile drug delivery system. Int J Curr Pharm Rev Res. 2011 May;2(2):55-80.

Rajput M, Sharma R, Kumar S, Jamil F, Sissodia N, Sharma S. Pulsatile drug delivery system: a review. Int J Res Pharm Biomed Sci. 2012 Jan;3(1):118-24.

Pavithra B, Naik VV, Sri KN. Pusatile drug delivery system-an overview. World J Pharm Res. 2019 Oct 29;9(1):716-33.

Yadav GD, Sharma PK, Rahate K. Colon targeted drug delivery system: delivery approaches, recent advancements and patent. World J Pharm Res. 2020;9(10):299-321.

Chandani G, Ganesh B, Preeti K. A comprehensive review of pulsatile drug delivery system. J Pharm Innov. 2012 Sep 1;7(A):99.

R Jadhav K, S Pacharane S, V Koshy P, J Kadam V. Smart polymers and their role in drug delivery: a review. Curr Drug Ther. 2010 Nov 1;5(4):250-61. doi: 10.2174/157488510792927456.

Kost J, Langer R. Responsive polymeric delivery systems. Adv Drug Deliv Rev. 2001;46(1-3):125-48. doi: 10.1016/s0169-409x(00)00136-8. PMID 11259837.

Sharma GS, Srikanth MV, Uhumwangho M, Phani KK, Ramana MK. Recent trends in pulsatile drug delivery systems- a review. Int J Drug Delivery. 2010 Jul 1;2(3):200-12. doi: 10.5138/ijdd.2010.0975.0215.02030.

Surve SB, Sapakal AD, Naingade SS. Chronotherapy-a new vista in novel drug delivery: an overview. Int J Pharm Biol Sci. 2013 Jan;3(1):378-6.

Patil J. Chronotherapeutics: a novel approach in the pharmacotherapy of various diseases. J Pharmacovigil. 2016 May 24;4(3). doi: 10.4172/2329-6887.1000e154.

Xie Y, Tang Q, Chen G, Xie M, Yu S, Zhao J, Chen L. New insights into the circadian rhythm and its related diseases. Front Physiol. 2019 Jun 25;10:682. doi: 10.3389/fphys.2019.00682, PMID 31293431.

Lin SY, Kawashima Y. Current status and approaches to developing press-coated chronodelivery drug systems. J Control Release. 2012 Feb 10;157(3):331-53. doi: 10.1016/j.jconrel.2011.09.065, PMID 21968338.

Jha N, Bapat S. Chronobiology and chronotherapeutics. Kathmandu Univ Med J (KUMJ). 2004 Oct–Dec;2(4):384-8. PMID 16388257.

Saini A, Gupta P. Chronotherapeutic agents: an overview. IRJPS. 2017 Sep;4(3):1144-52. doi: 10.21276/irjps.2017.4.3.8.

Rewar S, Bansal BK, Singh CJ, Sharma AK, Pareek R. Pulsatile drug delivery system: an overview. J Glob Trends Pharm Sci. 2014;5(3):1943-55.

Redkar MR, Patil SV, Nalkar SY, Pandav A, Shahapurkar AA. A comprehencive review on floating pulsatile drug delivery system. World J Pharm Res. 2019;8(8):304-29.

Youan BBC. Chronopharmaceutics: gimmick or clinically relevant approach to drug delivery? J Control Release. 2004 Aug 27;98(3):337-53. doi: 10.1016/j.jconrel.2004.05.015, PMID 15312991.

Durrington HJ, Farrow SN, Ray DW. Recent advances in chronotherapy for the management of asthma. Chronophysiol Ther. 2014 Nov 26;4:125-35. doi: 10.2147/CPT.S70845.

Skloot GS. Nocturnal asthma: mechanisms and management. Mt Sinai J Med. 2002 May;69(3):140-7. PMID 12035073.

Sajan J, Cinu TA, Chacko AJ, Litty J, Jaseeda T. Chronotherapeutics and chronotherapeutic drug delivery systems. Trop J Pharm Res. 2009 Oct;8(5):467-47. doi: 10.4314/tjpr.v8i5.48091.

Mandal AS, Biswas N, Karim KM, Guha A, Chatterjee S, Behera M, Kuotsu K. Drug delivery system based on chronobiology-A review. J Control Release. 2010 Nov 1;147(3):314-25. doi: 10.1016/j.jconrel.2010.07.122, PMID 20691738.

Greenberg H, Cohen RI. Nocturnal asthma. Curr Opin Pulm Med. 2012 Jan;18(1):57-62. doi: 10.1097/MCP.0b013e32834d098e, PMID 22045347.

Smolensky MH, Lemmer B, Reinberg AE. Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma. Adv Drug Deliv Rev. 2007 Aug 31;59(9-10):852-82. doi: 10.1016/j.addr.2007.08.016, PMID 17900748.

Martin RJ, Banks Schlegel S. Chronobiology of asthma. Am J Respir Crit Care Med. 1998 Sep;158(3):1002-7. doi: 10.1164/ajrccm.158.3.9712132, PMID 9731039.

Fitzpatrick MF, Engleman H, Whyte KF, Deary IJ, Shapiro CM, Douglas NJ. Morbidity in nocturnal asthma: sleep quality and daytime cognitive performance. Thorax. 1991 Aug;46(8):569-73. doi: 10.1136/thx.46.8.569, PMID 1926025.

Montplaisir J, Walsh J, Malo JL. Nocturnal asthma: features of attacks, sleep and breathing patterns. Am Rev Respir Dis. 1982 Jan;125(1):18-22. doi: 10.1164/arrd.1982.125.1.18, PMID 7065505.

Nainwal NN. Chronotherapeutics- a chronopharmaceutical approach to drug delivery in the treatment of asthma. J Control Release. 2012 Nov 10;163(3):353-60. doi: 10.1016/j.jconrel.2012.09.012, PMID 23022979.

Burioka N, Fukuoka Y, Koyanagi S, Miyata M, Takata M, Chikumi H, Takane H, Watanabe M, Endo M, Sako T, Suyama H, Ohdo S, Shimizu E. Asthma: Chronopharmacotherapy and the molecular clock. Adv Drug Deliv Rev. 2010 Jul 31;62(9-10):946-55. doi: 10.1016/j.addr.2010.03.012, PMID 20359514.

Pincus DJ, Humeston TR, Martin RJ. Further studies on the chronotherapy of asthma with inhaled steroids: the effect of dosage timing on drug efficacy. J Allergy Clin Immunol. 1997 Dec;100(6 Pt 1):771-4. doi: 10.1016/s0091-6749(97)70272-0, PMID 9438485.

Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald JM, Gibson P, Ohta K, O’Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008 Jan;31(1):143-78. doi: 10.1183/09031936.00138707, PMID 18166595.

GR Gadekar, SS Patil, RR Shah, DS Ghodke. Development and validation of a simple uv spectrophotometric method for the estimation of salbutamol sulphate from pharmaceutical formulations. Int J Curr Pharm Sci 2019;11(5):72-5. doi: 10.22159/ijcpr.2019v11i5.35707.

Qureshi J, Amir M, Ahuja A, Baboota S, Ali J. Chronomodulated drug delivery system of salbutamol sulphate for the treatment of nocturnal asthma. Indian J Pharm Sci. 2008 May–Jun;70(3):351-6. doi: 10.4103/0250-474X.43000, PMID 20046744.

Kadam VD, Gattani SG. Development of colon targeted multiparticulate pulsatile drug delivery system for treating nocturnal asthma. Drug Deliv. 2010 Jul;17(5):343-51. doi: 10.3109/10717541003762821, PMID 20429842.

Shukla D, Chakraborty S, Mishra B. Evaluation of in vivo behavior of controlled and pulsatile release pastilles using pharmacokinetic and γ-scintigraphic techniques. Expert Opin Drug Deliv. 2012 Nov;9(11):1333-45. doi: 10.1517/17425247.2012.716825, PMID 22924769.

Goud CM, Sravani Y. Formulation development of pulsatile drug delivery of tiotropium bromide. Am J PharmTech Res.. 2019;9(04):1-18.

Neeharika MS, Jyothi BJ. Preparation and evaluation of zafirlukast compression coated tablets for chronotherapeutic drug delivery. J Pharm Res Int. 2021 Jun 22;33(32B):154-66. doi: 10.9734/jpri/2021/v33i32B31757.

Ranjan OP, Nayak UY, Reddy MS, Dengale SJ, Musmade PB, Udupa N. Osmotically controlled pulsatile release capsule of montelukast sodium for chronotherapy: statistical optimization, in vitro and in vivo evaluation. Drug Deliv. 2014 Nov 1;21(7):509-18. doi: 10.3109/10717544.2013.853209, PMID 24215165.