FORMULATION AND DETERMINATION OF QUALITY PARAMETERS OF PROPOLIS EXTRACT MICROCAPSULE TABLETS FROM TETRAGONULA SAPIENS

DIAH KARTIKA PRATAMI; DENI RAHMAT; RIZKA NOOR AMALIA; HERI HERMASNYAH; MISRI GOZAN; MUHAMAD SAHLAN

doi:10.22159/ijap.2022.v14s1.10

Authors

DIAH KARTIKA PRATAMI Faculty of Pharmacy, Pancasila University, South Jakarta, DKI Jakarta, 12640, Indonesia
DENI RAHMAT Faculty of Pharmacy, Pancasila University, South Jakarta, DKI Jakarta, 12640, Indonesia
RIZKA NOOR AMALIA Faculty of Pharmacy, Pancasila University, South Jakarta, DKI Jakarta, 12640, Indonesia
HERI HERMASNYAH Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia
MISRI GOZAN Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia
MUHAMAD SAHLAN Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia

DOI:

https://doi.org/10.22159/ijap.2022.v14s1.10

Keywords:

Microcapsules, Propolis, Formulation, Tablet, Direct compress, Avicel pH 102, Quality parameters

Abstract

Objective: The study aimed to develop the dry powder of propolis microcapsules into tablet preparations.

Methods: The tablet preparation was developed by direct compression method using Avicel PH 102 (filler-binder-disintegrant) with variations in Avicel PH 102 concentration of 50%, 75%, and 100%, respectively. Each of the tablets from these formulations was determined by the quality parameters of the preparation.

Results: The results showed that the dry powder microcapsules had a yellow-brown powder physical form, flow time of 0.413g/second, compressibility of 18.56%, and fine powder was 80.04%. Out of the three formulae produced, formula III was the best with a tablet diameter of 11.11±0.01 mm, the thickness of 5.26±0.03 mm, disintegration time of 9.40±0.14 min, hardness of 15.46±0.84 kg/cm², weight uniformity of 506.74±2.86 mg, friability of 0.28±0.03%. Meanwhile, Pb and Cd metal contamination were not detected, microbial contamination with Total Plate Number gave (ALT) 4.20 x 10² colonies/g, Yeast Mold Number 1.18 x 10² colonies/g, and the water content of the tablet was 5.75%. The evaluation results also showed that formula III with a 100% Avicel PH 102 concentration had a relatively better disintegration time than others.

Conclusion: Propolis extract microcapsule tablet has been success developed. The best formula was used 100% Avicel PH 102 concentration.

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