DESIGN AND DEVELOPMENT OF SIMVASTATIN-LOADED PHARMACOSOMES TO ENHANCE TRANSDERMAL PERMEATION

S. NAVEENTAJ; Y. INDIRA MUZIB; R. RADHA

doi:10.22159/ijap.2022v14i4.44527

Authors

S. NAVEENTAJ Department of Pharmaceutics, Sri Padmavati Mahila Visvavidyalayam, [Women’s University], Tirupati 517502, Andhra Pradesh [A. P.], India https://orcid.org/0000-0002-5396-2540
Y. INDIRA MUZIB Department of Pharmaceutics, Sri Padmavati Mahila Visvavidyalayam, [Women’s University], Tirupati 517502, Andhra Pradesh [A. P.], India https://orcid.org/0000-0001-6933-0583
R. RADHA Department of Pharmaceutics, Sri Padmavati Mahila Visvavidyalayam, [Women’s University], Tirupati 517502, Andhra Pradesh [A. P.], India https://orcid.org/0000-0002-2996-2559

DOI:

https://doi.org/10.22159/ijap.2022v14i4.44527

Keywords:

Simvastatin, Carrier system, Transdermal permeation, Patches, Drug delivery systems, Bioavailability

Abstract

Objective: The objective of the selected study was to design and formulate simvastatin-loaded pharmacosomes and then incorporate into a transdermal patch by solvent evaporation technique to enhance the solubility, bioavailability, and half-life of simvastatin.

Methods: Simvastatin comes under the BCS-II class, which has low solubility and high permeability. Simvastain loaded pharmacosomes of six different formulations were prepared by taking simvastatin and soya lecithin in varying ratios and dissolved in a high polarity solvent dichloromethane and then subjected to the solvent evaporation method.

Results: Formulated simvastatin-loaded pharmacosomes (SLP) were subjected to evaluation; out of six formulations, optimized formulation (F3) shown in vitro drug release of 86.88%; particle size of 151.6 nm with zeta potential of-16.5mV, which indicates good stability. SEM studies confirmed their smooth, porous structure with a number of nano-channels. The FT-IR spectra and DSC showed a stable character of simvastatin in a mixture of lipid and solvent shows compatible and revealed the absence of drug polymer interactions. The SLP was loaded into a transdermal patch by solvent evaporation method and evaluated for physical characteristics and results were found to be patch surface pH 6.15±0.08, thickness 0.146±0.0096 mm, weight uniformity 1.12±1.73, % swell-ability 13.50±0.028 for best patch formulation (F3).

Conclusion: This research paper gives an outline on the significance of simvastatin-loaded Pharmacosomes as a transdermal patch for enhancing trans-permeation through the skin and its characterization and results. Through obtained results, it is concluded that pharmacosomes is a promising carrier to enhance the permeation of the selected drug through skin.

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