• K.E. POORNI Department of Biochemistry, Vivekanandha College of Arts and Sciences for Women (Autonomous), Elayampalayam, Tiruchengode, Tamilnadu, India
  • G. GOHULAVANI Department of Chemistry, Ethiraj College for Women, Chennai, Tamilnadu, India
  • VIVEK PANYAM MURALIDHARAN Department of Chemistry, School of Science and Humanities, Vel Tech Rangarajan, Dr. Sagunthala R&D Institute of Science and Technology, Chennai, Tamilnadu, India



Heterocyclic compounds, Chalcones, Pyrozaline Antimicrobial and Antioxidant activity


Objective: The present work is based on the above pyrazoline derivative form heterocyclic substituted chalcone.

Methods: The elemental analysis, IR, 1H and 13C NMR and mass spectrum analyses were used to characterise the structures of the obtained compounds.

Results: The scheme-1 and scheme-2 describe the synthesis of chalcone (thiophene-fluorenyl derivative) and synthesis of substituted pyrazolines respectively. Chalcone has been synthesized from 2-Acetylfluorene, which had been reacted with phenylhydrazine, 4-substituted phenylhydrazine (4-Chloro and 4-Nitro) and 2,4-Dinitrophenylhydrazine to form the substituted pyrazolines (CP01-CP04).

Conclusion: The antimicrobial and antioxidant properties were evaluated on those newly synthesised compounds.


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