ROLE OF VITAMIN D ON ANTI-MULLERIAN HORMONE (AMH) AND POLYMORPHISM OF AMHR II IN INFERTILITY: A REVIEW
DOI:
https://doi.org/10.22159/ijap.2022.v14ti.30Keywords:
AMHR II, Anti-Mullerian Hormone, Granulosa Cells, Infertility, Polymorphism, Vitamin DAbstract
Deficiency of vitamin D3 has become common in both developed and developing countries. Vitamin D receptors are found on the granulosa cells of ovarian tissue and its deficiency plays a role in ovarian dysfunction. Anti Mullerian Hormone (AMH) is generated in the small and growing follicles of ovaries by the granulosa cells. Serum AMH is one of the marker for ovarian reserve. We reviewed the current literature on Vitamin D3 and AMH in present clinical practice. There is a relationship between vitamin D3 and Anti-Mullerian Hormone, which exists at serum as well as genetic level. The AMH gene promoter has vitamin-D responsive elements, which gives the research-based evidence that AMH gene expression is effected by Vitamin D3. This systematical review is done to assess and encapsulate the available proof concerning the correlation between vitamin D3 and AMH and its type II receptor (AMHR II) functioning.
Downloads
References
Holick MF. Vitamin D deficiency. N Engl J Med. 2007 Jul 19;357(3):266-81. doi: 10.1056/NEJMra070553, PMID 17634462.
Satyanarayana U, Chakrapani U. Biochemistry. Revised Reprint. 5th ed. 2018. p. 127-30.
Lips P, Bouillon R, van Schoor NM, Vanderschueren D, Verschueren S, Kuchuk N. Reducing fracture risk with calcium and vitamin D. Clin Endocrinol (Oxf). 2010 Sep;73(3):277-85. doi: 10.1111/j.1365-2265.2009.03701.x. PMID 20796001.
Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology. 2000 Apr;141(4):1317-24. doi: 10.1210/endo.141.4.7403, PMID 10746634.
Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril. 2014 Aug;102(2):460-8.e3. doi: 10.1016/ j.fertnstert.2014.04.046. PMID 24933120.
Halloran BP, DeLuca HF. Effect of vitamin D deficiency on fertility and reproductive capacity in the female rat. J Nutr. 1980 Aug;110(8):1573-80. doi: 10.1093/jn/110.8.1573, PMID 7400847.
Merhi Z, Doswell A, Krebs K, Cipolla M. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J Clin Endocrinol Metab. 2014 Jun;99(6):E1137-45. doi: 10.1210/jc.2013-4161. PMID 24628555, PMCID PMC4037738.
Parikh G, Varadinova M, Suwandhi P, Araki T, Rosenwaks Z, Poretsky L. Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells. Horm Metab Res. 2010 Sep;42(10):754-7. doi: 10.1055/s-0030-1262837. PMID 20711952.
He C, Lin Z, Robb SW, Ezeamama AE. Serum vitamin D Levels and polycystic ovary syndrome: a systematic review and meta-analysis. Nutrients. 2015 Jun 8;7(6):4555-77. doi: 10.3390/nu7064555, PMID 26061015, PMCID PMC4488802.
Pergialiotis V, Karampetsou N, Panagopoulos P, Trakakis E, Papantoniou N. The effect of vitamin D supplementation on the hormonal and glycaemic profile of patients with PCOS: A meta-analysis of randomized trials. Int J Clin Pract. 2017 Jun;71(6). doi: 10.1111/ijcp.12957. PMID 28524342.
Krishnan AV, Moreno J, Nonn L, Malloy P, Swami S, Peng L. Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):694-702. doi: 10.1016/j.jsbmb.2006.12.051. PMID 17229571.
Shi XY, Huang AP, Xie DW, Yu XL. Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis. BMC Med Genet. 2019 Feb 14;20(1):32. doi: 10.1186/s12881-019-0763-5, PMID 30764792, PMCID PMC6376757.
Mohanasundaram S, Ramirez-Asis E, Quispe-Talla A, Bhatt MW, Shabaz M. Experimental replacement of hops by mango in beer: production and comparison of total phenolics, flavonoids, minerals, carbohydrates, proteins and toxic substances. Int J Syst Assur Eng Manag. 2022;13(S1):132-45. doi: 10.1007/s13198-021-01308-3.
Peluso C, Fonseca FL, Rodart IF, Cavalcanti V, Gastaldo G, Christofolini DM. AMH: an ovarian reserve biomarker in assisted reproduction. Clin Chim Acta. 2014 Nov 1;437:175-82. doi: 10.1016/j.cca.2014.07.029. PMID 25086280.
Seifer DB, Maclaughlin DT. Mullerian inhibiting substance is an ovarian growth factor of emerging clinical significance. Fertil Steril. 2007 Sep;88(3):539-46. doi: 10.1016/j.fertnstert.2007.02.014. PMID 17559842.
Tran D, Josso N. Relationship between avian and mammalian anti-Mulllerian hormones. Biol Reprod. 1977 Mar;16(2):267-73. doi: 10.1095/biolreprod16.2.267, PMID 831852.
Tal R, Seifer DB. Ovarian reserve testing: a user’s guide. Am J Obstet Gynecol. 2017 Aug;217(2):129-40. doi: 10.1016/j.ajog.2017.02.027. PMID 28235465.
La Marca A, Giulini S, Orvieto R, De Leo V, Volpe A. Anti-Mullerian hormone concentrations in maternal serum during pregnancy. Hum Reprod. 2005 Jun;20(6):1569-72. doi: 10.1093/humrep/deh819. PMID 15734752.
Van Rooij IA, Broekmans FJ, Te Velde ER, Fauser BC, Bancsi LF, de Jong FH. Serum anti-mullerian hormone levels: a novel measure of ovarian reserve. Hum Reprod. 2002 Dec;17(12):3065-71. doi: 10.1093/humrep/17.12.3065, PMID 12456604.
Van Rooij IA, Broekmans FJ, Scheffer GJ, Looman CW, Habbema JD, de Jong FH. Serum antimullerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: a longitudinal study. Fertil Steril. 2005 Apr;83(4):979-87. doi: 10.1016/j.fertnstert.2004.11.029. PMID 15820810.
Mohanasundaram S, Doss VA, Maddisetty P, Magesh R, Sivakumar K, Subathra M. Pharmacological analysis of a hydroethanolic extract of Senna alata (L.) for in vitro free radical scavenging and cytotoxic activities against Hep G2 cancer cell line. Pak J Pharm Sci. 2019;32(3):931-4.
Mullen RD, Behringer RR. Molecular genetics of mullerian duct formation, regression and differentiation. Sex Dev. 2014;8(5):281-96. doi: 10.1159/000364935. PMID 25033758, PMCID PMC4378544.
Visser JA, Themmen APN. Anti-mullerian hormone and folliculogenesis. Mol Cell Endocrinol. 2005;234(1-2):81-6. doi: 10.1016/j.mce.2004.09.008, PMID 15836956.
Pfennig F, Standke A, Gutzeit HO. The role of Amh signaling in teleost fish--Multiple functions not restricted to the gonads. Gen Comp Endocrinol. 2015 Nov 1;223:87-107. doi: 10.1016/j.ygcen.2015.09.025. PMID 26428616.
Segev DL, Hoshiya Y, Hoshiya M, Tran TT, Carey JL, Stephen AE. Mullerian-inhibiting substance regulates NF-kappa B signaling in the prostate in vitro and in vivo. Proc Natl Acad Sci USA. 2002 Jan 8;99(1):239-44. doi: 10.1073/pnas.221599298. PMID 11773638, PMCID PMC117545.
Mohanasundaram S, Rangarajan N, Sampath V, Porkodi K, Pennarasi M. GC-MS and HPLC analysis of antiglycogenolytic and glycogenic compounds in kaempferol 3-O–gentiobioside containing senna alata L. leaves in experimental rats. Translational Metab Syndr, (Research). 2021;4:10-7.
Segev DL, Hoshiya Y, Stephen AE, Hoshiya M, Tran TT, MacLaughlin DT. Mullerian inhibiting substance regulates NFkappaB signaling and the growth of mammary epithelial cells in vivo. J Biol Chem. 2001 Jul 20;276(29):26799-806. doi: 10.1074/jbc.M103092200. PMID 11356848.
Ujjan JA, Morani W, Memon N, Mohanasundaram S, Nuhmani S, Singh BK. Force platform-based intervention program for individuals suffering with neurodegenerative diseases like Parkinson. Comput Math Methods Med. 2022. doi: 10.1155/2022/1636263, PMID 35082910.
Umer S, Zhao SJ, Sammad A, Weldegebriall Sahlu B, Yunwei P, Zhu H. AMH: could it be used as A biomarker for fertility and superovulation in domestic animals? Genes (Basel). 2019 Dec 4;10(12):1009. doi: 10.3390/genes10121009, PMID 31817280, PMCID PMC6947652.
Baarends WM, van Helmond MJ, Post M, van der Schoot PJ, Hoogerbrugge JW, de Winter JP. A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the Mullerian duct. Development. 1994 Jan;120(1):189-97. doi: 10.1242/dev.120.1.189, PMID 8119126.
Sivakumar S, Mohanasundaram S, Rangarajan N, Sampath V, Velayutham Dass Prakash MV. In silico prediction of interactions and molecular dynamics simulation analysis of Mpro of a severe acute respiratory syndrome caused by novel coronavirus 2 with the FDA-approved nonprotein antiviral drugs. J Appl Pharm Sci. 2022;12(05):104-19. doi: 10.7324/JAPS.2022.120508.
Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril. 2014 Aug;102(2):460-468.e3. doi: 10.1016/ j.fertnstert.2014.04.046. PMID 24933120.
Pearce K, Gleeson K, Tremellen K. Serum anti-mullerian hormone production is not correlated with seasonal fluctuations of vitamin D status in ovulatory or PCOS women. Hum Reprod. 2015 Sep;30(9):2171-7. doi: 10.1093/humrep/dev167. PMID 26202912.
Dennis NA, Houghton LA, Jones GT, van Rij AM, Morgan K, McLennan IS. The level of serum anti-Mullerian hormone correlates with vitamin D status in men and women but not in boys. J Clin Endocrinol Metab. 2012 Jul;97(7):2450-5. doi: 10.1210/jc.2012-1213. PMID 22508713.
Rangarajan N, Sangeetha R, Mohanasundaram S, Sampath, Porkodi K, Dass Prakash MV. Additive inhibitory effect of the peels of Citrus limon and Citrus sinensis against amylase and glucosidase activity. IJRPS 2020;11(4):6876-80. doi: 10.26452/ijrps.v11i4.3661.
Merhi Z, Doswell A, Krebs K, Cipolla M. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J Clin Endocrinol Metab. 2014 Jun;99(6):E1137-45. doi: 10.1210/jc.2013-4161. PMID 24628555, PMCID PMC4037738.
Malloy PJ, Peng L, Wang J, Feldman D. Interaction of the vitamin D receptor with a vitamin D response element in the mullerian-inhibiting substance (MIS) promoter: regulation of MIS expression by calcitriol in prostate cancer cells. Endocrinology. 2009 Apr;150(4):1580-7. doi: 10.1210/en.2008-1555. PMID 19056816, PMCID PMC2659287.
Rangarajan N, Sampath, Dass Prakash M, Mohanasundaram S. UV Spectrophotometry and FTIR analysis of phenolic compounds with antioxidant potentials in glycyrrhiza glabra and zingiber officinale. Ijrps 2021;12(1):877-83. doi: 10.26452/ijrps.v12i1.4215.
Wu CH, Yang SF, Tsao HM, Chang YJ, Lee TH, Lee MS. Anti-Mullerian hormone gene polymorphism is associated with clinical pregnancy of fresh IVF cycles. Int J Environ Res Public Health. 2019 Mar 8;16(5):841. doi: 10.3390/ijerph16050841, PMID 30857124, PMCID PMC6427679.
Andersen CY, Byskov AG. Estradiol and regulation of anti-Mullerian hormone, inhibin-A, and inhibin-B secretion: analysis of small antral and preovulatory human follicles’ fluid. J Clin Endocrinol Metab. 2006 Oct;91(10):4064-9. doi: 10.1210/jc.2006-1066. PMID 16895952.
Doss VA, Mohanasundaram S, Maddisetty P. Analysis of hydroethanolic extract of Senna alata (L.) to screen bioactive compounds with inhibitory activity on lipid peroxidation, in vitro antibacterial and antidiabetic efficacy. Int J Pharm Sci. 2016;6(1):1360-6.
Rigon C, Andrisani A, Forzan M, D’Antona D, Bruson A, Cosmi E. Association study of AMH and AMHRII polymorphisms with unexplained infertility. Fertil Steril. 2010;94(4):1244-8. doi: 10.1016/j.fertnstert.2009.05.025. PMID 19539910.
Zhong X, Jin F, Huang C, Du M, Gao M, Wei X. DNA methylation of AMHRII and INSR gene is associated with the pathogenesis of polycystic ovary syndrome (PCOS). Technol Health Care. 2021;29 Suppl 1:11-25. doi: 10.3233/THC-218002, PMID 33682741, PMCID PMC8150467.
Mohanasundaram S, Doss VA, Haripriya G, Varsha M, Daniya S, Madhankumar. GC-MS analysis of bioactive compounds and comparative antibacterial potentials of aqueous, ethanolic and hydroethanolic extracts of Senna alata L. against enteric pathogens. Int J Res Pharm Sci. 2017;8(1):22-7.
Zhou SJ, Sun TC, Song LL, Yang M, Sun XP, Tian L. The status and comparison of ovarian reserve between fertile and infertile healthy Chinese women of reproductive age. Med (Baltim). 2021 Apr 30;100(17):e25361. doi: 10.1097/ MD.0000000000025361, PMID 33907092, PMCID PMC8084010.
Published
How to Cite
Issue
Section
Copyright (c) 2022 ASRA ANJUM, B SENTHIL KUMAR
This work is licensed under a Creative Commons Attribution 4.0 International License.
