ROLE OF INNATE IMMUNITY IN PERIODONTAL DISEASE: A BRIEF UPDATE
DOI:
https://doi.org/10.22159/ijap.2022.v14ti.44Keywords:
NLRP3, Inflammasome, Innate immunityAbstract
Periodontitis disease is the most condition caused by the inflammatory response in the periodontal tissue. It is well known and established that alone the presence of pathogenic bacteria is insufficient in causing periodontitis disease. Immune response and pathways play a key role in the development of lesions and hence it is necessary to understand the same to assess on how the disease is progressing. Further, it is observed that a comprehensive immune response is initiated in cases with periodontal disease. It is essential to summarize the mechanisms of the immune system involved in periodontal disease. Hence, to understand the immune mechanism and pathways that are also contributory factors for the progression of the disease, a database search is conducted with the keywords and two research articles are shortlisted and reviewed in this review article.
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Cugini C, Ramasubbu N, Tsiagbe VK, Fine DH. Dysbiosis from a microbial and host perspective relative to oral health and disease. Front Microbiol. 2021 Mar 5;12:617485. doi: 10.3389/fmicb.2021.617485, PMID 33763040, PMCID PMC7982844.
Arvina R, Sivaranjani S, Hema P, Arun Varghese R. Role of Immunology in periodontal disease: a brief review. Kumar VBNa. J Sci Dent. 2018;8(2):25-8.
Cekici A, Kantarci A, Hasturk H, Van Dyke TE. Inflammatory and immune pathways in the pathogenesis of the periodontal disease. Periodontol 2014 Feb;64(1):57-80. doi: 10.1111/prd.12002, PMID 24320956, PMCID PMC4500791.
Kumar M, Mishra L, Panda S, Satpathy A, Das AC, Mohanty G. Immune regulation in periodontal disease: a review. Indian J Forensic Med Toxicol. 2020;14(4):8124-7.
Mariano FS, Cassia J, Sardi O, Duque C. The role of the immune system in the development of the periodontal disease: a brief review. Rev Odontocienc. 2010;25(3):300-5.
Hirschfeld J. Neutrophil subsets in periodontal health and disease: a mini-review. Front Immunol. 2019;10:3001. doi: 10.3389/fimmu.2019.03001, PMID 31998301, PMCID PMC6961529.
Cueno ME, Ochiai K. Gingival periodontal disease (PD) level-butyric acid affects the systemic blood and brain organ: insights into the systemic inflammation of periodontal disease. Front Immunol. 2018 Jun 4;9:1158. doi: 10.3389/fimmu.2018.01158, PMID 29915575, PMCID PMC5994410.
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Copyright (c) 2022 PRADEEP KOPPOLU, RASHEED ABDULSALAM
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