PREPARATION AND EVALUATION OF A TASTE-MASKED ARTEMETHER ORAL SUSPENSION

SHITAL JAYANT BIDKAR; M. E. BHANOJI RAO; GANESH Y. DAMA; JAYANT S. BIDKAR; PRADNYA S. NAYKODI

doi:10.22159/ijap.2022.v14ti.45

Authors

SHITAL JAYANT BIDKAR Biju Patnaik University of Technology, Odisha, India, Sharadchandra Pawar College of Pharmacy, Otur, Pune, Maharashtra, India
M. E. BHANOJI RAO Roland Institute of Pharmaceutical Sciences, Berhampur, Odisha, India, Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences, Banitable, Uluberia, Howrah, West Bengal, India
GANESH Y. DAMA Sharadchandra Pawar College of Pharmacy, Otur, Pune, Maharashtra, India
JAYANT S. BIDKAR Sharadchandra Pawar College of Pharmacy, Otur, Pune, Maharashtra, India
PRADNYA S. NAYKODI Sharadchandra Pawar College of Pharmacy, Otur, Pune, Maharashtra, India

DOI:

https://doi.org/10.22159/ijap.2022.v14ti.45

Keywords:

Artemether, Taste-masked, Oral suspension

Abstract

Objective: The antimalarial drug Artemether is bitter in taste. The purpose of this work is to construct a taste-masked Artemether resinate employing ion exchange resins.

Methods: The process for drug resin complexation was adjusted in terms of drug resin ratio and medium pH. FTIR and DSC measurements were used to characterise the taste-masked complex. As an ion exchange resin, Indion 204 was used. It was combined with medication in various ratios: Indion was generated at various times and pH values and the extent of complexation was determined.

Results: The result indicates that a 1:1 ratio of Indion 204 to resin resulted in the largest amount of complexation after four hours of mixing. These resinate then converted into granules and they exhibit an angle of repose, bulk density, and flow characteristic values that are acceptable. The loading of drugs was greater than 99 percent. Based on drug content, a suitable amount of drug-resinate was taken for formulation. Then Suspension was studied for general appearance, viscosity, sedimentation ratio, drug release, resuspendability. The release test showed that 92.46% of drug were release within 120 min.

Conclusion: Hence we can conclude that Indion 204 has been proved to be useful as a taste-masking agent. Thus we are able to achieve our objectives of preparing a taste-masked suspension of Artemether with minimum excipients and a simple method of manufacturing.

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References

Nasr NEH, El Meshad AN, Fares AR. Nanocarrier systems in taste masking. Sci Pharm. 2022;90(1):20. doi: 10.3390/scipharm90010020.

Lopalco A, Manni A, Keeley A, Haider S, Li W, Lopedota A. In vivo investigation of (2-hydroxypropyl)-β-cyclodextrin-based formulation of spironolactone in aqueous solution for pediatric use. Pharmaceutics. 2022 Apr 3;14(4):780. doi: 10.3390/pharmaceutics14040780, PMID 35456614, PMCID PMC9029429.

Andrew EC, Grace EA, Elochukwu UC, Ezinne OC, Eze K. Formulation and development of controlled drug delivery of artemether using biopolymer. J Drug Des Med Chem. 2022;8(1):1-10.

Wolska E, Brach M. Distribution of drug substances in solid lipid microparticles (SLM)-methods of analysis and interpretation. Pharmaceutics. 2022 Jan 31;14(2):335. doi: 10.3390/pharmaceutics14020335, PMID 35214067, PMCID PMC8879661.

Zheng X, Wu F, Hong Y, Shen L, Lin X, Feng Y. Developments in taste-masking techniques for traditional Chinese medicines. Pharmaceutics. 2018 Sep 12;10(3):157. doi: 10.3390/pharmaceutics10030157, PMID 30213035, PMCID PMC6161181.

Pawar S, Shende P. A comparative outlook on pharmacokinetics and antimalarial studies of artemether and lumefantrine-loaded microneedle patches and a dry suspension containing nanosponges. J Drug Deliv Sci Technol. 2020;60:102055. doi: 10.1016/j.jddst.2020.102055.

Naik J, Rajput R, Singh MK. Development and evaluation of ibuprofen-loaded hydrophilic biocompatible polymeric nanoparticles for taste masking and solubility enhancement. BioNanoSci. 2021;11(1):21-31. doi: 10.1007/s12668-020-00798-y.

Van der Pluijm RW, Tripura R, Hoglund RM, Pyae Phyo A, Lek D, Ul Islam A. Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial. Lancet. 2020;395(10233):1345-60. doi: 10.1016/S0140-6736(20)30552-3, PMID 32171078.

Rao MRP, Bhutada K, Kaushal P. Taste evaluation by electronic tongue and bioavailability enhancement of efavirenz. AAPS PharmSciTech. 2019 Jan 7;20(2):56. doi: 10.1208/s12249-018-1277-8, PMID 30617434.

Nandhini J, Rajalakshmi AN. Dispersible tablets: a review. J Pharm Adv Res. 2018;1(3):148-55.

Faisal W, Farag F, Abdellatif AAH, Abbas A. Taste masking approaches for medicines. Curr Drug Deliv. 2018 Feb 14;15(2):167-85. doi: 10.2174/1567201814666171013145958, PMID 29034835.

Latin American Journal of Pharmacy (formerly Acta Farmacéutica Bonaerense). Lat Am J Pharm. 2010;29(2):198-204.