HIBISCUS ROSA-SINENSIS MUCILAGE AS A FUNCTIONAL POLYMER IN PHARMACEUTICAL APPLICATIONS: A REVIEW
DOI:
https://doi.org/10.22159/ijap.2023v15i1.46159Keywords:
Gums and mucilages, Hibiscus rosa-sinensis, Polymer, Excipient, Pharmaceutical dosage form, Drug deliveryAbstract
The administration of drugs into the body is essential for the treatment of diseases. However, drugs need to reach the targeted site to be effective. Excipients such as polymers are used in drug formulations to ensure that drugs exert their therapeutic effects. Recently, plant-based polymers have been extensively explored in pharmaceutical research. These polymers, including gums and mucilages, are investigated for their roles in various pharmaceutical applications. The plant-based polymers have advantages compared to synthetic polymers due to their bioavailability, chemical inertness, non-toxicity and wide availability. When gums or mucilages are combined with other polymers, their final properties improve. In some instances, the characteristics of gums and mucilages such as swelling, flow and mucoadhesive properties are better than the abilities of synthetic materials. This article reviews the use of Hibiscus rosa-sinensis (HRS) mucilage as an excipient in several dosage forms to enhance drug delivery systems. Their physicochemical properties and mechanisms of action are also discussed. The review ends with a discussion of the limitations and future prospects of HRS mucilage in pharmaceutical applications.
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Singh M, Dev D. Acacia catechu gum in situ forming gels with prolonged retention time for ocular drug delivery. Asian J Pharm Clin Res. 2022;15(9):33-40. doi: 10.22159/ajpcr.2022.v15i9.45269.
Dragan ES, Dinu MV. Polysaccharides constructed hydrogels as vehicles for proteins and peptides. A review. Carbohydr Polym. 2019;225:115210. doi: 10.1016/j.carbpol.2019.115210. PMID 31521316.
Prajapati VD, Jani GK, Moradiya NG, Randeria NP. Pharmaceutical applications of various natural gums, mucilages and their modified forms. Carbohydr Polym. 2013;92(2):1685-99. doi: 10.1016/j.carbpol.2012.11.021, PMID 23399207.
Madaan R, Bala R, Vasisht T, Sharma R, Garg S. Formulation and characterization of matrix tablets using mucilage of Tinospora cordifolia as natural binder. Int J Pharm Pharm Sci. 2018;10(7):22-7. doi: 10.22159/ijpps.2018v10i7.25447.
Kusuma R. Samba Shiva Rao A. Application of Ipomoea batata starch mucilage as suspending agent in oseltamivir suspension. Int J Curr Pharm Res. 2015;7(4):58-62.
Ameena K, Dilip C, Saraswathi R, Krishnan PN, Sankar C, Simi SP. Isolation of the mucilages from Hibiscus rosasinensis linn. and Okra (Abelmoschus esculentus linn.) and studies of the binding effects of the mucilages. Asian Pac J Trop Med. 2010;3(7):539-43. doi: 10.1016/S1995-7645(10)60130-7.
Malviya R, Srivastava P, Kulkarni GT. Applications of mucilages in drug delivery-a review. Adv Biol Res. 2011;5(1):1-7.
Prajapati V, Bansal M, Sharma K. Mucoadhesive buccal patches and use of natural polymer in its preparation-a review. Int J PharmTech Res. 2012;4(2):582-9.
Jania GK, Shahb DP, Prajapatia VD, Jain VC. Gums and mucilages: versatile excipients for pharmaceutical formulations. Asian J Pharm Sci. 2014;4:308-23.
Saidin NM, Anuar NK, Tin Wui W, Meor Mohd Affandi MMR, Wan Engah WR. Skin barrier modulation by Hibiscus rosa-sinensis L. mucilage for transdermal drug delivery. Polym Bull. 2022;79(5):3099-115. doi: 10.1007/s00289-021-03658-1.
Dharmendra S, Surendra JK, Sujata M, Shweta S. Natural excipients-A review. Int J Pharm Biol Sci Arch. 2012;3(5):1028-34.
Choudhary PD, Pawar HA. Recently investigated natural gums and mucilages as pharmaceutical excipients: an overview. J Pharm (Cairo). 2014;2014:204849. doi: 10.1155/2014/204849. PMID 26556189.
Jadhav VM, Thorat RM, Kadam VJ, Sathe NS. Traditional medicinal uses of Hibiscus rosa-sinensis. J Pharm Res. 2009;2(7):1220-2.
Kumar A, Singh A. Review on Hibiscus rosa-sinensis. Int J Res Pharm Biomed Sci. 2012;3(2):534-8.
Akpan GA. Hibiscus. In: Anderson NO, editor. Flower breeding and genetics: issues, challenges and opportunities for the 21st century. Dordrecht: Kluwer Academic Publishers; 2006. p. 479-89. doi: 10.1007/1-4020-4428-3.
Reveendran A, Varghese S, Viswanathan K. Green synthesis of silver Nano particle using Hibiscus rosa sinensis. IOSR JAP. 2016;8(3):35-8. doi: 10.9790/4861-0803023538.
Vignesh RM, Nair BR. Extraction and characterisation of mucilage from the leaves of Hibiscus rosa-sinensis Linn. (Malvaceae). Int J Pharm Sci Res. 2018;9(7):2883-90. doi: 10.13040/IJPSR.0975-8232.9(7).2883-90.
Kassakul W, Praznik W, Viernstein H, Hongwiset D, Phrutivorapongkul A, Leelapornpisid P. Characterization of the mucilages extracted from Hibiscus rosa-sinensis linn and Hibiscus mutabilis linn and their skin moisturizing effect. Int J Pharm Pharm Sci. 2014;6(11):453-7.
Shimizu N, Tomoda M, Suzuki I, Takada K. Plant mucilages. XLIII. A representative mucilage with biological activity from the leaves of Hibiscus rosa-sinensis. Biol Pharm Bull. 1993;16(8):735-9. doi: 10.1248/bpb.16.735, PMID 8220317.
Dalvadi HP, Shah D, Saralai MG, Patel JK. Evaluating the mucoadhesive properties of mucilage of Hibiscus Rosa sinensis Linn., drug delivery systems. Int J Pharm Res Technol. 2013;3(1):16-21.
Lakshmi PK, Narendra Y, Rewanthwar SL, Neeharika V. Comparative evaluation of natural and synthetic superdisintegrants in the formulation of fast dissolving tablets. Turk J Pharm Sci. 2013;10(3):351-66.
Ahad HA, Kumar CS, Kishore Kumar Reddy B, Ravindra BV, Sasidhar CGS, Abhilash C, Sagar NR V. Designing and evaluation of diclofenac sodium sustained release matrix tablets using Hibiscus rosa-sinensis leaves mucilage. Int J Pharm Sci Rev Res 2010;1(2):29–31.
Roy A, K Haldar P, Chhetri A. Experimentation on Hibiscus rosa flower mucilage as a potential nasal mucoadhesive its characterization as an in situ gel for some anxiolytics. J Young Pharm. 2016;8(2):82-90. doi: 10.5530/jyp.2016.2.5.
Barua A, Hossain MR, Sultana R, Mazumder K, Absar N, Hossain R. Isolation and characterization of mucilage from tinospora cordifolia as tablet binder and release modifier. TJNPR 2019;3(1):1-5. doi: 10.26538/tjnpr/v3i1.1.
Bahadur S, Roy A, Baghel P, Choudhury A, Saha S, Chanda R. Formulation and evaluation of glipizide tablets utilizing Hibiscus Rosasinensis leaves mucilage. Indonesian J Pharm. 2018;29(1):23-8. doi: 10.14499/indonesianjpharm29iss1pp23.
Ibrahim MA, Abou El Ela AESF. Optimized furosemide taste masked orally disintegrating tablets. Saudi Pharm J. 2017;25(7):1055-62. doi: 10.1016/j.jsps.2017.04.002. PMID 29158715.
Carnaby Mann G, Crary M. Pill swallowing by adults with dysphagia. Arch Otolaryngol Head Neck Surg. 2005;131(11):970-5. doi: 10.1001/archotol.131.11.970, PMID 16301368.
Nagar PK. Superdisintegrants-current approach. J Drug Delivery Ther 2014;4(3):37-4. doi: 10.22270/jddt.v4i3.831.
Alam MT, Parvez N, Sharma PK. FDA-approved natural polymers for fast dissolving tablets. J Pharm (Cairo). 2014;2014:952970. doi: 10.1155/2014/952970, PMID 26556207.
Shah V, Patel R. Studies on mucilage from Hibiscus rosa-sinensis linn. As oral disintegrant. Int J Appl Pharm. 2010;2(1):18-21.
Chaurasiya N, Chakraborthy GS. Formulation and evaluation of herbal hydrogel from Hibiscus rosa-sinensis. Int J Curr Pharm Res. 2014;6(1):14-6.
Bhowmik D, Gopinath H, Kumar BP, Duraivel S, Kumar KPS. Controlled release drug delivery systems. J Pharm Innov. 2012;1(10):24-32.
Kaleemullah M, Jiyauddin K, Thiban E, Rasha S, Al-Dhalli S, Budiasih S. Development and evaluation of ketoprofen sustained release matrix tablet using Hibiscus rosa-sinensis leaves mucilage. Saudi Pharm J. 2017;25(5):770-9. doi: 10.1016/j.jsps.2016.10.006. PMID 28725150.
Collins Ov A, Uwumagbe MU. Formulation and evaluation of effervescent floating matrix tablets of a biguanide using Grewia mollis gum. Asian J Appl Sci. 2019;12(2):91-8. doi: 10.3923/ajaps.2019.91.98.
George B, Suchithra TV. Plant-derived bioadhesives for wound dressing and drug delivery system. Fitoterapia. 2019;137:104241. doi: 10.1016/j.fitote.2019.104241. PMID 31201885.
More RS, Rs K, Un M. Formulation and evaluation of gastroretentive floating tablet using hibiscus rosa-sinensis mucilage. Asian J Pharm Clin Res 2017;10(3):444-8. doi: 10.22159/ajpcr.2017.v10i3.16494.
Palla N, Rajashekar V, Marni P, Mittepalli J, Sridhar KA. Formulation and in vitro evaluation of tramadol hydrochloride floating tablets. Int Res J Pharm. 2016;4(4):138-44. doi: 10.7897/2230-8407.04428.
Pereira GA, Silva EK, Peixoto Araujo NM, Arruda HS, Meireles MAA, Pastore GM. Mutamba seed mucilage as a novel emulsifier: stabilization mechanisms, kinetic stability and volatile compounds retention. Food Hydrocoll. 2019;97:105190. doi: 10.1016/j.foodhyd.2019.105190.
Ash D, Ghosh P, Majee SB, Biswas GR. Hibiscus leaf mucilage as stabiliser for pharmaceutical disperse systems. Int J Appl Pharm. 2019;11(2):6-11. doi: 10.22159/ijap.2019v11si2.31308.
McClements DJ, Bai L, Chung C. Recent advances in the utilization of natural emulsifiers to form and stabilize emulsions. Annu Rev Food Sci Technol. 2017;8:205-36. doi: 10.1146/annurev-food-030216-030154, PMID 28125353.
Adedokun MO, Olorunsola EO, Anselem EL. Comparative evaluation of metronidazole suspensions formulated with Raphia africana hydrocolloid and other natural polymers. J App Pharm Sci. 2017;7(6):121-6. doi: 10.7324/JAPS.2017.70616.
Salamat Miller N, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Deliv Rev. 2005;57(11):1666-91. doi: 10.1016/j.addr.2005.07.003. PMID 16183164.
Boddupalli BM, Mohammed ZNK, Nath RA, Banji D. Mucoadhesive drug delivery system: an overview. J Adv Pharm Technol Res. 2010;1(4):381-7. doi: 10.4103/0110-5558.76436, PMID 22247877.
Russo E, Selmin F, Baldassari S, Gennari CGM, Caviglioli G, Cilurzo F. A focus on mucoadhesive polymers and their application in buccal dosage forms. J Drug Deliv Sci Technol. 2016;32:113-25. doi: 10.1016/j.jddst.2015.06.016.
Tyagi S, Sharma N, Gupta SK, Sharma A, Bhatnagar A, Kumar N. Development and gamma scintigraphical clearance study of novel Hibiscus Rosasinensis polysaccharide based mucoadhesive nasal gel of rizatriptan benzoate. J Drug Deliv Sci Technol. 2015;30:100-6. doi: 10.1016/j.jddst.2015.10.002.
Bashir Pathan I, Mallikarjuna Setty C. Chemical penetration enhancers for transdermal drug delivery systems. Trop J Pharm Res. 2009;8(2):173-17. doi: 10.4314/tjpr.v8i2.44527.
Lv HX, Zhang ZH, Wang XP, Cheng QQ, Wang W, Huang XH. A biomimetic chitosan derivates: preparation, characterization and transdermal enhancement studies of N-arginine chitosan. Molecules. 2011;16(8):6778-90. doi: 10.3390/molecules16086778, PMID 21829153.
Paudel KS, Milewski M, Swadley CL, Brogden NK, Ghosh P, Stinchcomb AL. Challenges and opportunities in dermal/transdermal delivery. Ther Deliv. 2010;1(1):109-31. doi: 10.4155/tde.10.16, PMID 21132122.
Jayapirakasam SV, Prabakaran L, Donthireddy BR. Formulation development and characterization of Hibiscus rosa-sine sis dry leaves mucilage as smart polymer for pharmaceutical use. Int J Appl Res Nat Prod. 2015;8(2):28-36.
Gouda K, Kishore V, Balaji N, Kumar V, Raghuram N. Development and evaluation of propranolol hydrochloride floating matrix tablets using combination of natural and synthetic polymers. Res J Pharm Dosage Forms Technol. 2011;3(6):276-80.
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