DESIGN AND DEVELOPMENT OF PHYTOSOMAL SOFT NANOPARTICLES FOR LIVER TARGETING
DOI:
https://doi.org/10.22159/ijap.2023v15i1.46303Keywords:
Ferulic acid, Conjugation, Complex formation, Solvent evaporation method, Solvent evaporation technique, Nanoparticle, Drug targeted systems, BioavailabilityAbstract
Objective: The objective of the study was to design and formulate ferulic acid (FA) phytosomes converted in to functionalised soft nanoparticles by using the solvent evaporation method to increase resistance time, improve the bioavailability and half-life of ferulic acid.
Methods: FA is a BCS-II drug, which has low solubility and high permeability. The functionalised soft nanoparticles was prepared by the solvent evaporation method followed by the particle size and zeta potential, Fourier Transform Infra-Red (FTIR), Powder x-Ray Diffraction (PXRD), Scanning Electron Microscope (SEM). It indicates good result for the complexation rate. PXRD showed good powder diffraction results with having good flow property. Particle size and zeta potential had a good result of-12.05±120 improved by the cationic polymer. The complex was evaluated by the study of drug loading, entrapment efficiency, histopathological study and mucoadhesive property for the final formulation of the microspheres system. Also, the formulation were evaluated for the In vitro drug dissolution study for rate of the extent of drug release. Ex-vivo drug diffusion study by using goat nasal mucosa using pH 6.6 for evaluating rate of the extent of drug diffusion through nasal mucosa.
Results: The results of the characterization studies indicated the designing of functionalised phytosomal soft nanoparticles (FPSN). The FPSN particle size and zeta potential had a good result of-12.05±120. The FTIR spectra of the complex showed a characteristic peak at 3652.8 cm-1(OH-stretching) which indicate that the shifting and interaction between the FA and soya phospholipid complex (SPC 3). The P-XRD, SEM, In vitro dissolution showed good powder diffraction results with having good flow property. The complex is evaluated by the study of drug loading. Also formulation were evaluated for the In vitro drug dissolution study for rate of the extent of drug release. The result of the above studies was Drug loading increased at 44.42 %. The Ex-vivo permeation study ferulic acid-phytosomal soft nanoparticle (FALC-PSN) showed characteristic in the drug diffusion at 80.04 %, which indicate that the drug had increases its aqueous solubility and also change with the structural morphology.
Conclusion: It can be concluded that the ferulic acid phytosomal soft nanoparticles (FAPSN) enhance the solubility of the FA and increased the bioavailability and retention time to target liver cancer.
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