MECHANISM OF ACTION, SYNTHESIS, PROPERTIES AND ANALYTICAL METHODS OF CABOZANTINIB

AKANKSHA DWIVEDI; RAKHI KHABIYA; ALANKAR SHRIVASTAVA; SIDDHARTH TYAGI; KANDASAMY NAGARAJAN; G. N. DARWHEKAR

doi:10.22159/ijap.2023v15i1.46409

Authors

AKANKSHA DWIVEDI Acropolis Institute of Pharmaceutical Education and Research, Indore, MP
RAKHI KHABIYA Acropolis Institute of Pharmaceutical Education and Research, Indore, MP
ALANKAR SHRIVASTAVA KIET Group of Institutions (KIET School of Pharmacy), Delhi-NCR, Meerut Road (NH-58), Ghaziabad 201206 https://orcid.org/0000-0003-3284-0445
SIDDHARTH TYAGI KIET Group of Institutions (KIET School of Pharmacy), Delhi-NCR, Meerut Road (NH-58), Ghaziabad 201206
KANDASAMY NAGARAJAN KIET Group of Institutions (KIET School of Pharmacy), Delhi-NCR, Meerut Road (NH-58), Ghaziabad 201206
G. N. DARWHEKAR Acropolis Institute of Pharmaceutical Education and Research, Indore, MP

DOI:

https://doi.org/10.22159/ijap.2023v15i1.46409

Keywords:

Cabozantinib, Cancer, Analytical methods, Spectrophotometry, Chromatography

Abstract

Globally, the burden of cancer is substantial and growing. The impact of the burden of such diseases over society is unpredictable in terms of health lost and cost. Unfortunately, the estimates shown the burden may be increasing in the upcoming decades. Cabozantinib (CBZ) is a newly developed tyrosin kinase inhibitor (TKI) for Differentiated thyroid cancer (DTC), Hepatic Cellular Carcinoma (HCC), Medullary thyroid cancer (MTC) and Renal Cell Carcinoma (RCC). The objective of the presented review is to provide updated knowledge of drugs especially covering analytical methodologies. The review covered the introduction, mechanism of action, pharmacokinetics, synthesis and developed analytical methods by various researchers. The review covered one spectrophotometry and about twenty chromatography methods. The review will be helpful for the scientist working in this area and especially helpful for analytical scientists exploring new analytical methodologies for CBZ.

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