NICORANDIL MUCOADHESIVE MICROSPHERES: FORMULATION DEVELOPMENT, PHYSICO-CHEMICAL AND FUNCTIONAL CHARACTERIZATION

ANKITA V. HADKE; ANIL M. PETHE; MAHESH A. KESALKAR

doi:10.22159/ijap.2023v15i2.46593

Authors

ANKITA V. HADKE Datta Meghe College of Pharmacy, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra, India https://orcid.org/0000-0001-7163-0307
ANIL M. PETHE Datta Meghe College of Pharmacy, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra, India https://orcid.org/0000-0002-6380-1847
MAHESH A. KESALKAR Institute of Pharmaceutical Education and Research, Wardha, Maharashtra, India https://orcid.org/0000-0001-7869-3247

DOI:

https://doi.org/10.22159/ijap.2023v15i2.46593

Keywords:

Nicorandil, Microspheres, Polymer, Glutaraldehyde

Abstract

Objective: The study aims to prepare and evaluate Nicorandil mucoadhesive microspheres to improve the oral physicochemical properties of nicorandil and mucoadhesion to extend the residence time at the absorption site.

Methods: Nicorandil mucoadhesive microsphere was prepared by emulsion cross-linking method using fenugreek gum, karaya gum as polymer, and glutaraldehyde as a cross-linking agent. Drug entrapment efficiency, particle size, % swelling index, mucoadhesion study, differential scanning calorimetry, powder x-ray diffraction, Fourier transform infrared spectroscopy, and in vitro dissolution studies were used to characterize the microspheres.

Results: The characterization studies indicated the formation of mucoadhesive microspheres. The nicorandil mucoadhesive microspheres particle size is130.83±0.48, entrapment efficiency 66.91±0.54, swelling index 82.69±0.40, % mucoadhesion 95.22±0.13 and in vitro drug release was found to be 89.96±0.17 % at the end of 12 h.

Conclusion: This research work successfully formed nicorandil mucoadhesive microspheres formulation using the emulsion cross-linking method. Encapsulation efficiency and other physicochemical and functional characterization of microspheres suggested the successful formation of nicorandil mucoadhesive microspheres.

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