THIOLATED MORINGA EXUDATE GUM AS IMPROVED BIO-MUCOADHESIVE AGENT IN THE FORMULATIONS OF DENTAL PASTE AND GEL

PRANAB KUMAR BANDYOPADHYAY; AMIT KUMAR NAYAK

doi:10.22159/ijap.2023v15i1.46647

Authors

PRANAB KUMAR BANDYOPADHYAY Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj 757086, Odisha, India https://orcid.org/0000-0003-3446-5482
AMIT KUMAR NAYAK Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj 757086, Odisha, India https://orcid.org/0000-0002-3704-4619

DOI:

https://doi.org/10.22159/ijap.2023v15i1.46647

Keywords:

Mucoadhesive polymer, Plant polysaccharide, Moringa exudate gum, Drug delivery, Dental paste, Mucoadhesive gel

Abstract

Objective: The objectives of the current study were to synthesize thiolated moringa exudate gum (TMEG) via thiolation of moringa exudate gum (MEG) and to evaluate TMEG as an improved bio-mucoadhesive agent in semi-solid formulations like dental paste and gel. MEG-and TMEG-based mucoadhesive dental pastes of aceclofenac and mucoadhesive gels of metronidazole were prepared and changes in bio-mucoadhesion capability were studied.

Methods: In the current study, extracted MEG was modified to synthesize TMEG via thiolation (by utilizing thioglycolic acid in an acidic milieu) to study improvement in bio-mucoadhesive capability. MEG-and TMEG-based mucoadhesive dental pastes of 1% w/w aceclofenac and mucoadhesive gels of 1% w/w metronidazole were prepared with MEG and TMEG (as mucoadhesive excipient) in order to evaluate a comparative view of improvement in bio-mucoadhesion.

Results: The yield percentage of TMEG was found to be 44.62% and the thiol group in TMEG was found 4.17 mmol of thiol group/g of MEG. FTIR analysis results indicated the thiolation of MEG in the synthesized TMEG. Both types of semi-solid formulations (mucoadhesive dental pastes of 1% w/w aceclofenac and mucoadhesive gels of 1% w/w metronidazole) prepared using TMEG as mucoadhesive excipient exhibited excellent improved ex vivo bio-mucoadhesion and a sustained pattern of drug-releasing over a prolonged period.

Conclusion: The synthesized TMEG can be used as an improved mucoadhesive agent in the designing of bio-mucoadhesive semi-solid formulations for prolonged drug delivery.

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