TARGETING ANGIOGENESIS WITH FLUPHENAZINE-ZINC OXIDE NANOCONJUGATES: A POTENTIAL MECHANISM FOR IMPROVING ANTIPSYCHOTIC EFFICACY

NAGASEN DASARI; SUJIYA BALLA; PYDIRAJU KONDRAPU; RAMAKRISHNA GUMMADI; NOOKARAJU SURADA; UMA MAHESWARI KONDRU; SAI KIRAN S. S. PINDIPROLU

doi:10.22159/ijap.2023v15i5.48317

Authors

NAGASEN DASARI Aditya Pharmacy College, Surampalem-533437, Andhra Pradesh, India. Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh, India https://orcid.org/0000-0002-8305-7277
SUJIYA BALLA Aditya Pharmacy College, Surampalem-533437, Andhra Pradesh, India. Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh, India https://orcid.org/0000-0002-5400-4491
PYDIRAJU KONDRAPU Aditya Pharmacy College, Surampalem-533437, Andhra Pradesh, India. Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh, India https://orcid.org/0000-0002-5400-4491
RAMAKRISHNA GUMMADI Aditya Pharmacy College, Surampalem-533437, Andhra Pradesh, India. Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh, India
NOOKARAJU SURADA Aditya Pharmacy College, Surampalem-533437, Andhra Pradesh, India. Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh, India
UMA MAHESWARI KONDRU Aditya Pharmacy College, Surampalem-533437, Andhra Pradesh, India. Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh, India
SAI KIRAN S. S. PINDIPROLU Aditya Pharmacy College, Surampalem-533437, Andhra Pradesh, India. Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh, India

DOI:

https://doi.org/10.22159/ijap.2023v15i5.48317

Keywords:

Antipsychotics, Fluphenazine, Zinc oxide nanoparticles, Psychosis, Drug delivery systems

Abstract

Objective: This study aimed to develop a more effective formulation of Fluphenazine (FLP) for the management of psychosis. Antipsychotics are widely used for the treatment of severe mental disorders such as schizophrenia and bipolar disorder. However, their clinical use is limited due to various side effects and low efficacy in a large number of patients. Nanoparticle-based drug delivery systems have shown great potential in improving the pharmacokinetics and pharmacodynamics of various drugs, including antipsychotics. Zinc oxide nanoparticles (ZnO NPs) have emerged as a promising carrier for drug delivery due to their unique physicochemical properties, biocompatibility, and low toxicity.

Methods: In this study, we reported the preparation and characterization of FLU-encapsulated ZnO NPs (FLU-ZnO-NPs) for the management of psychosis. The synthesized FLU-ZnO-NPs were characterized using various techniques, such as X-Ray Diffractometer, Energy Dispersive X-Ray analysis, Transmission Electron Microscopy, and Zetasizer (Malvern).

Results: The characterization results showed that the synthesized FLU-ZnO-NPs had improved solubility, enhanced bioavailability, targeted delivery, and reduced toxicity.

Conclusion: The development of FLU-ZnO-NPs could provide a more effective and safe treatment option for patients with mental disorders.

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References

Zuchowska A, Kasprzak A, Dabrowski B, Kaminska K, Poplawska M, Brzozka Z. Nanoconjugates of graphene oxide derivatives and meso-tetraphenyl porphyrin: a new avenue for anticancer photodynamic therapies–cell-on-a-chip analysis. New J Chem. 2020;44(43):18770-9. doi: 10.1039/D0NJ04189K.

Zhao H, Wang D, Gao C, Liu H, Han L, Yin Y. Ultrafine platinum/iron oxide nanoconjugates confined in silica nanoshells for highly durable catalytic oxidation. J Mater Chem A. 2016;4(4):1366-72. doi: 10.1039/C5TA09215A.

Yousuf S, Arjmand F, Siddique HR, Ali MS, Al-Lohedan HA, Tabassum S. Biophysical binding profile with ct-DNA and cytotoxic studies of a modulated nanoconjugate of umbelliferone cobalt oxide loaded on graphene oxide (GO) as drug carrier. J Biomol Struct Dyn. 2022;40(10):4558-69. doi: 10.1080/07391102.2020.1860821, PMID 33331234.

Yang C. Bactericidal functionalization of wrinkle-free fabrics via covalently bonding TiO 2@Ag nanoconjugates. Journal of Materials Science 2009;44:1894-901.

Yadav N, Kumar N, Prasad P, Shirbhate S, Sehrawat S, Lochab B. Stable dispersions of covalently tethered polymer improved graphene oxide nanoconjugates as an effective vector for siRNA delivery. ACS Appl Mater Interfaces. 2018;10(17):14577-93. doi: 10.1021/acsami.8b03477, PMID 29634909.

Wang N, Yu X, Zhang K, Mirkin CA, Li J. Upconversion nanoprobes for the ratiometric luminescent sensing of nitric oxide. J Am Chem Soc. 2017;139(36):12354-7. doi: 10.1021/jacs.7b06059, PMID 28844137.

Turin Moleavin IA, Fifere A, Lungoci AL, Rosca I, Coroaba A, Peptanariu D. In vitro and in vivo antioxidant activity of the new magnetic-cerium oxide nanoconjugates. Nanomaterials (Basel). 2019;9(11):1565. doi: 10.3390/nano9111565, PMID 31690040.

Turiel Fernandez D. Ultrasmall iron oxide nanoparticles cisplatin (IV) prodrug nanoconjugate: ICP-MS based strategies to evaluate the formation and drug delivery capabilities in single cells. Anal Chim Acta. 2021;1159:338356. doi: 10.1016/j.aca.2021.338356.

Pindiprolu SKSS, Avasarala H, Dinakaran SK. Phenylboronic acid modified lipid nanocarriers mediated co-delivery of immunocytokine TRAIL and gamma-secretase inhibitor to triple-negative breast cancer cells and cancer stem cells. Med Hypotheses. 2021;157:110716. doi: 10.1016/j.mehy.2021.110716. PMID 34731681.

Anshika S, Rajora A, Mazumder R, Padhi S. Effect of ZEIN on ciprofloxacin floating tablets. Int J Appl Pharm. 2022;14(6):137-47.

Pindiprolu SKSS, Madhan J, Srinivasarao DA, Dasari N, Phani Kumar CS, Katta C. Therapeutic targeting of aberrant sialylation for prevention of chemoresistance and metastasis in triple negative breast cancer. J Drug Deliv Sci Technol. 2023 Jun 14;86:104617. doi: 10.1016/j.jddst.2023.104617.

Moya C, Escudero R, Malaspina DC, de la Mata M, Hernandez Saz J, Faraudo J. Insights into preformed human serum albumin corona on iron oxide nanoparticles: structure, effect of particle size, impact on mri efficiency, and metabolization. ACS Appl Bio Mater. 2019;2(7):3084-94. doi: 10.1021/acsabm.9b00386, PMID 35030800.

Sarkar P, Das S, Majee SB. Solid dispersion tablets in improving oral bioavailability of poorly soluble drugs. Int J Curr Pharm Sci. 2022;14(2, Mar):15-20. doi: 10.22159/ ijcpr.2022v14i2.1961.

Chintamaneni PK, Nagasen D, Babu KC, Mourya A, Madan J, Srinivasarao DA. Engineered upconversion nanocarriers for synergistic breast cancer imaging and therapy: current state of the art. J Control Release. 2022 Dec;352:652-72. doi: 10.1016/j.jconrel.2022.10.056, PMID 36328078.

Maru AD, Lahoti SR. Formulation and evaluation of ointment containing sunflower wax. Asian J Pharm Clin Res. 2019;12(8 Aug):115-20. doi: 10.22159/ajpcr.2019.v12i18.33199.

Chintamaneni PK, Nagasen D, Babu KC, Mourya A, Madan J, Srinivasarao DA. Engineered upconversion nanocarriers for synergistic breast cancer imaging and therapy: current state of the art. J Control Release. 2022;352:652-72. doi: 10.1016/j.jconrel.2022.10.056. PMID 36328078.

Chen F, Chen D, Deng T, Li J. Combination of alkaline phosphatase/graphene oxide nanoconjugates and D-glucose-6-phosphate–functionalized gold nanoparticles for the rapid colorimetric assay of pathogenic bacteria. Biosens Bioelectron. 2022;216:114611. doi: 10.1016/j.bios.2022.114611. PMID 35985060.

Chauhan RP, Mathur R, Singh G, Kaul A, Bag N, Singh S. Evaluation of folate conjugated superparamagnetic iron oxide nanoparticles for scintigraphic/magnetic resonance imaging. J Biomed Nanotechnol. 2013;9(3):323-34. doi: 10.1166/jbn.2013.1548, PMID 23620987.

Chakraborty SP, Mahapatra SK, Sahu SK, Chattopadhyay S, Pramanik P, Roy S. Nitric oxide-mediated staphylococcus aureus pathogenesis and protective role of nano conjugated vancomycin. Asian Pac J Trop Biomed. 2011;1(2):102-9. doi: 10.1016/S2221-1691(11)60005-1, PMID 23569737.

Veronica EF, Dwiastuti R. Formulation and evaluation of wound healing gel of white lead tree (Leucaena leucocephala (lam.) DE wit.) leaves extract. Int J App Pharm. 2022;14:275-80. doi: 10.22159/ijap.2022v14i1.42126.

Ali MS, Tabassum S, Al-Lohedan HA, Farah MA, Al-Anazi KM, Usman M. Fluorescent delivery vehicle containing cobalt oxide–umbelliferone nanoconjugate: DNA/protein interaction studies and anticancer activity on MF7 cancer cell line. RSC Adv. 2019;9(45):26503-18. doi: 10.1039/c9ra02412c, PMID 35531044.

Joshi S, Siddiqui R, Sharma P, Kumar R, Verma G, Saini A. Green synthesis of peptide-functionalized reduced graphene oxide (rGO) nano bioconjugate with enhanced antibacterial activity. Sci Rep. 2020;10(1):9441. doi: 10.1038/s41598-020-66230-3, PMID 32523022.

Gonzalez Rodriguez R, Sizemore E, Naumov AV. Graphene oxide-iron oxide nanoconjugates for drug transport, biosensing and bimodal fluorescence/magnetic resonance imaging. Electrochemical Society Meeting Abstracts. 2018;01(6):669. doi: 10.1149/MA2018-01/6/669.

Armenia I, Marcone GL, Berini F, Orlandi VT, Pirrone C, Martegani E. Magnetic nano conjugated teicoplanin: a novel tool for bacterial infection site targeting. Front Microbiol. 2018;9:2270. doi: 10.3389/fmicb.2018.02270, PMID 30386305.

Achadu OJ, Britton J, Nyokong T. Graphene quantum dots functionalized with 4-Amino-2, 2, 6, 6-tetramethylpiperidine-n-oxide as fluorescence “Turn-ON” Nanosensors. J Fluoresc. 2016;26(6):2199-212. doi: 10.1007/s10895-016-1916-y. PMID 27624186.