QUALITY BY DESIGN APPROACH FOR DEVELOPMENT AND OPTIMIZATION OF CHITOSAN-BASED FLOATING MICROSPHERES FOR TOPOTECAN HCl
DOI:
https://doi.org/10.22159/ijap.2023v15i6.48850Keywords:
Bio-availability, Topotecan hydrochloride, Chitosan, Floating microspheres, Quality by designAbstract
Objective: To develop floating microspheres for the topotecan in order to prevent its onversion into inactive carboxylate form in intestinal pH conditions so as to improve its bioavailability.
Methods: Chitosan-based porous floating microspheres containing sodium bicarbonate by coacervation technique were developed. Quality by design approach using Box-Behnken Design was adopted to assess the influences of selected formulation variables and their importance on the quality of the finished product.
Results: The selected model was analyzed and optimized. The microspheres floated immediately without any lag time upon addition into water and remained floatable for more than 24 h-1. The optimized formulation was found to have the particle size of 379.2 µm, entrapment efficiency of 76.3% and the drug release rate constant of 0.29 h i.e., the release was extended up to 16 h-1.
Conclusion: The results affirmed that controlled-release porous microspheres of Topotecan with inherent floating without lag were successfully developed.
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Copyright (c) 2023 Prahlad Pragallapati, VENKATA RAMANA MURTHY KOLLAPALLI, REVATHI NAGA LAKSHMI PONNURI
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