DEVELOPMENT AND EVALUATION OF NANOSPHERES CONTAINING CARBIMAZOLE
DOI:
https://doi.org/10.22159/ijap.2023v15i6.48966Keywords:
Carbimazole, Targeted drug delivery, Polymeric nanospheres, Chitosan, Nano-precipitation methodAbstract
Objective: To develop and evaluate polymeric nanospheres of Carbimazole using Nano-precipitation method.
Methods: The polymeric nanospheres of Carbimazole were prepared employing the nano-precipitation method using a varied concentration of Chitosan (polymer). The prepared formulations were characterized for several parameters such as SEM, Particle size, Micromeritic properties, Encapsulation efficiency, Degree of swelling, Percentage moisture loss, drug content, and in vitro drug release and release kinetics.
Results: Carbimazole-loaded polymeric nanospheres were developed, and the evaluation parameters depicted results within an acceptable range. The result of FTIR studies shows that there is no interaction between drug and excipients. The melting point, obtained as per the reference standard (122-125 °C) depicted the purity and authenticity of the drug. The micromeritics studies also supported the characterization of drug and excipients. The drug content was found to be in the range of 80.3±0.65 to 99.5±0.81 for all six formulations. The entrapment efficacy was obtained for all six formulations and ranged from 82.17 to 99.56. The release parameters were also observed for all formulations, and they were determined in the range of 82.5±0.4 for formulation NS6 (12 h) to 98.6±0.9 for formulation NS4 (24 h).
Conclusion: The results revealed thatthe formulation containing a higher concentration of Chitosan and a lower concentration of Tween 80 showed prolonged in vitro drug release in a controlled manner. Hence, On the basis of all formulation results, the NS4 was the best formulation among all.
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