FORMULATION AND EVALUATION OF NANOPARTICLE DRUG DELIVERY SYSTEM FOR TREATMENT OF HYPERTENSION

GAUTHAM U.; ANASUYA PATIL; HEMANTH G.

doi:10.22159/ijap.2023v15i6.48971

Authors

GAUTHAM U. Department of Pharmaceutics, KLE College of Pharmacy, Bengaluru, India https://orcid.org/0009-0005-0760-1436
ANASUYA PATIL Department of Pharmaceutics, KLE College of Pharmacy, Bengaluru, India https://orcid.org/0000-0001-6096-6278
HEMANTH G. Department of Pharmaceutics, KLE College of Pharmacy, Bengaluru, India https://orcid.org/0009-0002-9525-032X

DOI:

https://doi.org/10.22159/ijap.2023v15i6.48971

Keywords:

Trandolapril, Solid lipid nanoparticles, Hypertension, Hot-homogenisation, Ultrasonication

Abstract

Objective: The aim of the current research is to formulate and evaluate Trandolapril loaded solid lipid nanoparticles (SLNs) for the management of high blood pressure.

Methods: SLNs were formulated using Glyceryl monostearate and poloxamer 188 by hot homogenisation and ultrasonication method. Different concentrations of lipid and surfactant were used for the preparation adopting 3² full factorial design. The prepared formulations were initially evaluated for particle size, PDI, zeta potential and entrapment efficiency to obtain the optimised formulation.

Results: The optimised formulation TF 6 reported the particle size of 212.6±5.39 nm and entrapment efficiency of 91.02±0.57%; this was further characterised for FT-IR, DSC and scanning electron microscopy. The in vitro release of drug for the prepared formulations was performed for 24 h and the optimised formulation showed better-controlled drug release compared to other formulations.

Conclusion: The pure Trandolapril solution was collated with the optimised formulation TF 6 and the result concluded that the formulation showed controlled drug release compared to pure drug. This study proves that Trandolapril SLNs can be prepared for increasing the release of drug for prolonged period.

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