AN OVERVIEW OF DISCRETE NANOFORMULATED FLAVONOIDS AND ITS IMPLICATION IN CANCER
DOI:
https://doi.org/10.22159/ijap.2023v15i6.49104Keywords:
Nanoemulsion, Nanosuspension, Polymeric nanoparticle, Nanovesicle, Nano conjugation, and cancerAbstract
The nanoformulation of phytochemical has been developed to withdraw the drawbacks of conventional phytochemical. Nanoformulations are the nanosized particles, modified in order to improve the delivery of active phytochemicals in the target, to improve bioavailability, and solubility. Early researches shows that various phytochemicals like curcumin, Hesperidin, resveratrol, ellagic acid, essential oil, Naringenin, and quercitin are highly modified to form the nanoformulated compounds to improve its bio-activities. The nanoformulated phytochemicals are syntheized by various methods such as high energy and low energy emulsification, electrostatic stabilization, emulsification/reverse salting-out, nanoprecipitation, emulsification/solvent diffusion, solvent evaporation, and multi-arm Nanoconjugates, enzyme responsive nanoconjugates, core-crosslinked nanoconjugate hydrophobic–hydrophilic nanoconjugates, and nanoconjugate-based solid dispersion. Interestingly, the encapsulation of phytochemicals with surfactants, oils, emulsifying agents, salting-out agents will promote the antioxidant, antitumor, cytotoxic agents and antimicrobial effects than a raw phytochemicals. Various studies showed that phytochemicals are nanoformulated by the nanoemulsion method are better in terms of active target drug delivery, increasing bioavailability and it also act as an effective biological and diagnosting agents. This review focus on Innovative approaches to nanoformulated phytochemicals and their biomedical applications.
Downloads
References
Mohanty C, Sahoo SK. The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation. Biomaterials. 2010 Sep;31(25):6597-611. doi: 10.1016/j.biomaterials.2010.04.062, PMID 20553984.
Lee WH, Loo CY, Young PM, Traini D, Mason RS, Rohanizadeh R. Recent advances in curcumin nanoformulation for cancer therapy. Expert Opin Drug Deliv. 2014 Aug;11(8):1183-201. doi: 10.1517/17425247.2014.916686, PMID 24857605.
Ahmed H, Aboul-Enein A, Abou-Elella F, Salem S, Aly H, Nassrallah A, Habiba A, Ahmed A. Nano-formulations of hesperidin and essential oil extracted from sweet orange peel: chemical properties and biological activities. Egypt J Chem. 2021. doi: 10.21608/EJCHEM.2021.84783.4139.
Harakeh S, Qari MH, Ramadan WS, Al Jaouni SK, Almuhayawi MS, Al Amri T. A novel nanoformulation of ellagic acid is promising in restoring oxidative homeostasis in rat brains with alzheimer’s disease. Curr Drug Metab. 2021;22(4):299-307. doi: 10.2174/1389200221666201216170851, PMID 33327909.
Sa H, Dia VP, Baek SJ, Zhong Q. Nanoencapsulation of apigenin with whey protein isolate: physicochemical properties, in vitro activity against colorectal cancer cells, and bioavailability. Lebensm Wiss Technol. 2022;154. https://doi.org/10.1016/j.lwt.2021.112751
Lorectal cancer cells, and bioavailability. Lebensm Wiss Technol. 2022 Jan 15;154:112751. doi: 10.1016/j.lwt, PMID 34840350.
Nagamani DB, Reddy KB. Implementation of factorial design to optimize the formulation method of ezetimibe polymeric nanoparticle by homogenization cum ultra-sonication method. Int J App Pharm. 2022;14(2):151-9. doi: 10.22159/ijap.2022v14i2.43783.
Majumdar D, Jung KH, Zhang H, Nannapaneni S, Wang X, Ruhul Amin ARM. Chen1, and dong M. Shin1, 2015, luteolin nanoparticle in chemoprevention–in vitro and in vivo anticancer activity. Cancer Prev Res (Phila). 2014 Jan;7(1):65-73. doi: 10.1158/1940-6207.
Houacine C, Singh KK. Nano resveratrol a promising future nanonutraceutical Nanonutraceuticals. 1st ed. Vol. 2018; 2019. doi: 10.1201/9781351138949-10.
Zielinska A, Carreiro F, Oliveira AM, Neves A, Pires B, Venkatesh DN. Polymeric Nanoparticles: production, characterization, toxicology and ecotoxicology. Molecules. 2020 Aug 15;25(16):3731. doi: 10.3390/molecules25163731, PMID 32824172.
Szczech M, Szczepanowicz K. Polymeric core-shell nanoparticles prepared by spontaneous emulsification solvent evaporation and functionalized by the layer-by-layer method. Nanomaterials (Basel). 2020 Mar 10;10(3):496. doi: 10.3390/nano10030496, PMID 32164194.
Wang Y, Li P, Truong Dinh Tran T, Zhang J, Kong L. Manufacturing techniques and surface engineering of polymer based nanoparticles for targeted drug delivery to cancer. Nanomaterials (Basel). 2016 Feb 1;6(2):26. doi: 10.3390/nano6020026, PMID 28344283.
Martinez Rivas CJ, Tarhini M, Badri W, Miladi K, Greige Gerges H, Nazari QA. Nanoprecipitation process: from encapsulation to drug delivery. Int J Pharm. 2017 Oct 30;532(1):66-81. doi: 10.1016/j.ijpharm.2017.08.064, PMID 28801107.
Lim K, Hamid ZAA. Polymer nanoparticle carriers in drug delivery systems: research trend. In: Asiri AM, Mohammad A. editors. Applications of nanocomposite materials in drug delivery; Inamuddin. Cambridge, UK: Woodhead Publishing; 2018. p. 217-37.
Gao M, Long X, Du J, Teng M, Zhang W, Wang Y. Enhanced curcumin solubility and antibacterial activity by encapsulation in PLGA oily core nanocapsules. Food Funct. 2020;11(1):448-55. doi: 10.1039/c9fo00901a, PMID 31829367.
Illahi AF, Muhammad F, Akhtar B. Nanoformulations of nutraceuticals for cancer treatment. Crit Rev Eukaryot Gene Expr. 2019;29(5):449-60. doi: 10.1615/CritRevEukaryotGeneExpr.2019025957, PMID 32422001.
Jummes B, Sganzerla WG, da Rosa CG, Noronha CM, Nunes MR, Bertoldi FC. Antioxidant and antimicrobial poly-ε-caprolactone nanoparticles loaded with cymbopogon martinii essential oil. Biocatal Agric Biotechnol. 2020;23(Jan):101499. doi: 10.1016/j.bcab.2020.101499.
Silva Flores PG, Perez Lopez LA, Rivas Galindo VM, Paniagua Vega D, Galindo Rodriguez SA, Alvarez Roman R. Simultaneous GC-FID quantification of main components of Rosmarinus officinalis L. and Lavandula dentata essential oils in polymeric nanocapsules for antioxidant application. J Anal Methods Chem. 2019 Feb 10;2019:2837406. doi: 10.1155/2019/2837406, PMID 30881726.
Jaiswal M, Dudhe R, Sharma PK. Nanoemulsion: an advanced mode of drug delivery system. 3 Biotech. 2015 Apr;5(2):123-7. doi: 10.1007/s13205-014-0214-0, PMID 28324579.
Zang X, Cheng M, Zhang X, Chen X. Quercetin nanoformulations: a promising strategy for tumor therapy. Food Funct. 2021;12(15):6664-81. doi: 10.1039/d1fo00851j, PMID 34152346.
Gokhale JP, Mahajan HS, Surana SJ. Quercetin loaded nanoemulsion-based gel for rheumatoid arthritis: in vivo and in vitro studies. Biomed Pharmacother. 2019;112:108622. doi: 10.1016/j.biopha.2019.108622, PMID 30797146.
Ahmadi Oskooei F, Mehrzad J, Asoodeh A, Motavalizadehkakhky A. Olive oil-based quercetin nanoemulsion (QuNE)’s interactions with human serum proteins (HSA and HTF) and its anticancer activity. J Biomol Struct Dyn. 2023;41(3):778-91. doi: 10.1080/07391102.2021.2012514, PMID 34919017.
Altamimi MA, Hussain A, Alshehri S, Imam SS, Alnemer UA. Development and evaluations of transdermally delivered luteolin loaded cationic nanoemulsion: in vitro and ex vivo evaluations. Pharmaceutics. 2021;13(8):1218. doi: 10.3390/pharmaceutics13081218, PMID 34452179.
Ghazya OA, Fouadb MT, Saleha HH, Kholifb AE, TA Morsy. Ultrasound-assisted preparation of anise extract nanoemulsion and its bioactivity against different pathogenic bacteria. Food Chem. 2021 Mar 30;341(2):128259. doi: 10.1016/j.foodchem.2020.128259.
Cavar S, Maksimovic M, Solic ME, Jerkovic Mujkic A, Besta R. Chemical composition and antioxidant and antimicrobial activity of two satureja essential oils. Food Chem. 2008;111(3):648-53. doi: 10.1016/j.foodchem.2008.04.033.
Maccelli A, Vitanza L, Imbriano A, Fraschetti C, Antonello Filippi, Paola Goldoni, Linda Maurizi, Maria Grazia Ammendolia, Maria Elisa Crestoni, Simonetta Fornarini, Luigi Menghini, Maria Carafa, Carlotta Marianecci, Catia Longhi, Federica Rinaldi. Satureja montana L. essential oils: chemical profiles/phytochemical screening, antimicrobial activity and o/w nanoemulsion formulations. Pharmaceutics. 2019 Dec 19;12(1):7. doi: 10.3390/pharmaceutics12010007.
Santos Rodrigues AP, Faria E Souza BS, Alves Barros AS, de Oliveira Carvalho H, Lobato Duarte J, Leticia Elizandra Boettger M. The effects of rosmarinus officinalis L. essential oil and its nanoemulsion on dyslipidemic wistar rats. J Appl Biomed. 2020 Dec;18(4):126-35. doi: 10.32725/jab.2020.016, PMID 34907765.
Navaei Shoorvarzi SN, Shahraki F, Shafaei N, Karimi E, Oskoueian E. Citrus aurantium L. bloom essential oil nanoemulsion: synthesis, characterization, cytotoxicity, and its potential health impacts on mice. J Food Biochem. 2020;44(5):e13181. doi: 10.1111/jfbc.13181, PMID 32173879.
Salehi F, Jamali T, Kavoosi G, Ardestani SK, Vahdati SN. Stabilization of Zataria essential oil with pectin-based nanoemulsion for enhanced cytotoxicity in monolayer and spheroid drug-resistant breast cancer cell cultures and deciphering its binding mode with gDNA. Int J Biol Macromol. 2020 Dec 1;164:3645-55. doi: 10.1016/j.ijbiomac.2020.08.084, PMID 32795576.
Rajan Sailaja G, Venkatraman Sriramavaratharajan, Ramar Murugan, Gopal Rao Mallavarapu, David Raj Chellappan. Vasorelaxant property of Plectranthus vettiveroides root essential oil and its possible mechanism. J Ethnopharmacol. 2021 Jun 28;274:114048. doi: 10.1016/j.jep.2021.114048.
Bashlouei SG, Karimi E, Zareian M, Oskoueian E, Shakeri M. Heracleum persicum essential oil nanoemulsion: a nanocarrier system for the delivery of promising anticancer and antioxidant bioactive agents. Antioxidants (Basel). 2022 Apr 25;11(5):831. doi: 10.3390/antiox11050831, PMID 35624695.
Lobato Rodrigues ABL, Martins RL, Rabelo EM, Tomazi R, Santos LL, Brandao LB. Development of nano-emulsions based on Ayapana triplinervis essential oil for the control of Aedes aegypti larvae. PLOS ONE. 2021 Jul 9;16(7):e0254225. doi: 10.1371/journal.pone.0254225, PMID 34242328.
Kotta S, Mubarak Aldawsari H, Badr Eldin SM, Alhakamy NA, Md S. Coconut oil-based resveratrol nanoemulsion: optimization using response surface methodology, stability assessment and pharmacokinetic evaluation. Food Chem. 2021;357:129721. doi: 10.1016/j.foodchem.2021.129721, PMID 33866243.
Liu MH, Li YF, Chen BH. Inhibition of melanoma cells A375 by carotenoid extract and nanoemulsion prepared from pomelo leaves. Plants (Basel). 2021;10(10):2129. doi: 10.3390/plants10102129, PMID 34685938.
Fernandez Luqueno F, Medina Perez G, Perez Soto E, Espino Manzano S, Peralta Adauto L, Perez Rios S. Bioactive compounds of opuntia spp. acid fruits: micro and nano-emulsified extracts and applications in nutraceutical foods. Molecules. 2021 Oct 25;26(21):6429. doi: 10.3390/molecules26216429, PMID 34770840.
Hong C, Dang Y, Lin G, Yao Y, Li G, Ji G. Effects of stabilizing agents on the development of myricetin nanosuspension and its characterization: an in vitro and in vivo evaluation. Int J Pharm. 2014 Dec 30;477(1-2):251-60. doi: 10.1016/j.ijpharm.2014.10.044, PMID 25445518.
Sun M, Gao Y, Pei Y, Guo C, Li H, Cao F. Development of nanosuspension formulation for oral delivery of quercetin. J Biomed Nanotechnol. 2010 Aug;6(4):325-32. doi: 10.1166/jbn.2010.1133, PMID 21323105.
Ben Shabat S, Yarmolinsky L, Porat D, Dahan A. Antiviral effect of phytochemicals from medicinal plants: applications and drug delivery strategies. Drug Deliv Transl Res. 2020 Apr;10(2):354-67. doi: 10.1007/s13346-019-00691-6, PMID 31788762, PMCID PMC7097340.
Li W, Ng KY, Heng PW. Development and evaluation of optimized sucrose ester stabilized oleanolic acid nanosuspensions prepared by wet ball milling with design of experiments. Biol Pharm Bull. 2014;37(6):926-37. doi: 10.1248/bpb.b13-00864, PMID 24882406.
Bhia M, Motallebi M, Abadi B, Zarepour A, Pereira Silva M, Saremnejad F. Naringenin nano-delivery systems and their therapeutic applications. Pharmaceutics. 2021;13(2). doi: 10.3390/pharmaceutics13020291, PMID 33672366.
Donoso Quezada J, Guajardo Flores D, Gonzalez Valdez J. Enhanced exosome-mediated delivery of black bean phytochemicals (Phaseolus vulgaris L.) for cancer treatment applications. Biomed Pharmacother. 2020 Nov;131:110771. doi: 10.1016/j.biopha.2020.110771, PMID 33152932.
Vanti G, Tomou EM, Stojkovic D, Ciric A, Bilia AR, Skaltsa H. Nanovesicles loaded with origanum onites and satureja thymbra essential oils and their activity against food-borne pathogens and spoilage microorganisms. Molecules. 2021 Apr 7;26(8):2124. doi: 10.3390/molecules26082124, PMID 33917147.
Tran TTD, Tran PHL. Nanoconjugation and encapsulation strategies for improving drug delivery and therapeutic efficacy of poorly water-soluble drugs. Pharmaceutics. 2019;11(7). doi: 10.3390/pharmaceutics11070325, PMID 31295947.
Samrot AV, Saigeetha S, Mun CY, Abirami S, Purohit K, Cypriyana PJJ. Utilization of Carica papaya latex on coating of SPIONs for dye removal and drug delivery. Sci Rep. 2021 Dec 31;11(1):24511. doi: 10.1038/s41598-021-03328-2, PMID 34972829.
Mahajanakatti AB, Deepak TS, Achar RR, Pradeep S, Prasad SK, Narayanappa R. Nanoconjugate synthesis of elaeocarpus ganitrus and the assessment of its antimicrobial and antiproliferative properties. Molecules. 2022 Apr 10;27(8):2442. doi: 10.3390/molecules27082442, PMID 35458641.
Published
How to Cite
Issue
Section
Copyright (c) 2023 LAVANYA M., RAMAKRISHNAN PADMINI
This work is licensed under a Creative Commons Attribution 4.0 International License.
