ANTI-ALOPECIA ACTIVITY OF MORINGA (MORINGA OLEIFERA LAMK.) SEED OIL AGAINST DIHYDROTESTOSTERONE-INDUCED RABBITS

YULIUS BAKI KORASSA; NYI MEKAR SAPTARINI; RESMI MUSTARICHIE; RINI HENDRIANI; ANTONIUS R. B. OLA; YOAN NOVICADLITHA; LELY A V KAPITAN

doi:10.22159/ijap.2023.v15s2.04

Authors

YULIUS BAKI KORASSA Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Bandung-45363, Indonesia. Pharmacy Study Program, Health Polytechnic of Ministry of Health in Kupang-405020, East Nusa Tenggara, Indonesia https://orcid.org/0000-0002-6115-8675
NYI MEKAR SAPTARINI Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Bandung-45363, Indonesia
RESMI MUSTARICHIE Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Bandung-45363, Indonesia
RINI HENDRIANI Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran-45363, Bandung, Indonesia
ANTONIUS R. B. OLA Department of Chemistry, Faculty of Science and Engineering, Nusa Cendana University-85001, Kupang, Indonesia. Integrated Research Center (Bioscience) Laboratory, Nusa Cendana University-85001, Kupang, Indonesia
YOAN NOVICADLITHA Medical Laboratory Technologists Study Program, Health Polytechnic of Ministry of Health in Kupang-405020, East Nusa Tenggara, Indonesia
LELY A V KAPITAN Pharmacy Study Program, Health Polytechnic of Ministry of Health in Kupang-405020, East Nusa Tenggara, Indonesia

DOI:

https://doi.org/10.22159/ijap.2023.v15s2.04

Keywords:

Moringa oleifera Lamk, Antialopecia, Finasteride, Growth hair

Abstract

Objective: Alopecia is a condition where there is hair loss or no growth of hair, which can occur as a result of stress, heredity, hormonal factors or due to certain diseases such as diabetes mellitus. This study aimed to determine the anti-alopecia activity of moringa seed oil against rabbits induced by dihydrotestosterone (DHT).

Methods: The methods used was the alopecia rabbit model according to Matias with moringa seed oil concentrations of 7.5, 10 and 12.5%, positive control (0.1% finasteride) and negative control (1% tween 80) with parameters hair length and hair weight test.

Results: Results showed that moringa seed oil concentrations of 7.5, 10 and 12.5% had anti-alopecia activity with average hair length of 3.4±0.17, 3.9±0.20 and 4.5±0.28 cm, respectively and average hair weight of 118±23.148±30.9 and 175±47.2 mg respectively.

Conclusion: Moringa seed oil concentration of 12.5% had optimal activity for developing as anti-alopecia based on the statistical analysis value of hair length (125x10^-3>0.05) was not significantly different while hair weight (3x10^-3<0.05) was significantly different from the positive control of 0.1% finasteride.

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