DRUG EXCIPIENT ADSORPTION TECHNIQUE FOR THE PREPARATION OF LOW-DOSE TABLETING
DOI:
https://doi.org/10.22159/ijap.2024v16i5.50991Keywords:
Low-dose tablet, Cetirizine, DAF, Content uniformity, FTIR.Abstract
Objective: This study aimed to improve drug mixability and drug uniformity in low-dose tablet by developing a stable easily mixable drug adsorbed filler.
Methods: The research involved adsorbing drug on filler by using three solvents and drug-to-excipient ratios of 1:50 and 1:75. This drug adsorbed fillers (DAF), drug content uniformity and flow properties were characterized which are crucial for accurate dosing and manufacturing.
Results: Formulations T1 and T2 and T3 showed similar flow properties, including bulk and tapped densities, Carr's indices, and Hausner ratios. T1 had better flowability with a lower angle of repose (23.97 degrees) than T2 (35.42 degrees), T3 (49 degrees), and T4 (39 degrees) and higher drug uniformity (99.89%, 99.54%, 97.12%, 96.83%). Tablet evaluations of TS1, TS2, TS3, TS4 met standard weight variation, friability, and hardness criteria, with TS1 showing a quicker disintegration time (2:58, 3:10, 3:15, 4), indicating faster dissolution and potentially better bioavailability. Dissolution tests showed both exceeded 85% drug release in 30 minutes, with TS1 achieving a higher release (99.98, 99.91%, 98.11%, 97.64%), suggesting more efficient drug release.
Conclusion: The drug adsorbed filler premix technique effectively ensures drug content uniformity and improves low-dose drug mixing, contributing to the development of safe, efficient low-dose pharmaceuticals.
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