ADVANCING TOPICAL POSACONAZOLE DELIVERY: BOX BEHNKEN DESIGN MICROSPONGE HYDROGEL OPTIMIZATION AND EXTENSIVE IN VIVO INVESTIGATION

REKHA RANI KUPPALA; P. RAVI PRAKASH; N. DEVANNA

doi:10.22159/ijap.2024v16i6.51167

Authors

REKHA RANI KUPPALA Research and Development, Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Anantapur-515001, AP, India https://orcid.org/0000-0001-5329-6878
P. RAVI PRAKASH Department of Pharmaceutics, Creative Educational Society’s College of Pharmaceutical Sciences (Affiliated to Jawaharlal Nehru Technological University, Anantapur), Kurnool, AP, India
N. DEVANNA Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur-515001, AP, India

DOI:

https://doi.org/10.22159/ijap.2024v16i6.51167

Abstract

Objective: The primary aim of this study was to develop a novel hydrogel formulation containing Posaconazole (PCZ) encapsulated within microsponges. Furthermore, the study aimed to assess the permeation properties of this formulation in vivo using a mouse model.

Methods: To achieve this aim, a series of seventeen trials were conducted using the Box Behnken Design methodology. These trials were designed to optimize the production of PCZ Microsponges (PCZ MS), which were subsequently incorporated into a hydrogel matrix. Skin permeation studies were then performed to evaluate the ability of the PCZ microsponge-based hydrogel to deliver the drug across the skin barrier. These studies involved comparison with a standard hydrogel formulation lacking microsponges.

Results: This study assessed the efficacy of microsponge gel formulation PM-3 for drug entrapment, yield, and sustained release compared to a conventional gel. PM-3 displayed the highest entrapment efficiency of 98.5% and a yield of 95.62%, indicating a direct correlation with the 1:1 drug-polymer ratio. Moreover, PM-3 exhibited sustained drug release over 12 hours, releasing 83.82% of PCZ compared to 65.31% with the normal gel, suggesting its potential for prolonged therapeutic action. These findings underscore the promise of microsponge-based hydrogels, like PM-3, in enhancing therapeutic outcomes through sustained drug release, warranting further exploration for clinical applications.

Conclusion: The findings of this study highlight the promising potential of microsponge-based hydrogels as effective carriers for localized drug delivery, particularly in the context of treating skin fungal infections

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