FORMULATION AND EVALUATION OF LICORICE OIL-BASED EMULGEL FOR THE TREATMENT OF PSORIASIS
DOI:
https://doi.org/10.22159/ijap.2024v16i5.51471Keywords:
Licorice oil, Carbopol 934, Topical formulation, Psoriasis, Emulgel, HaCaT cell lineAbstract
Objective: The aim of the present research work was to develop and evaluate the topical emulgel incorporated with licorice oil for the effective management of psoriasis.
Methods: The present study involves the preparation and optimization of licorice oil-based emulsion using tween 80, span 20, propylene glycol and was loaded in gel base (carbopol 940 was used as gelling agent). The prepared emulgel were evaluated for various parameters such as particle size, zeta potential, entrapment efficiency, spreadibility, pH, viscosity, Fourier-Transform Infrared Spectroscopy (FTIR), in vitro release studies and in vitro cell line study.
Results: The optimized formulation was found to have droplet size of 54.50 nm,-14.1 V zeta potential, entrapment efficiency of 59.53±8.42 % and spreadibility of 2.901±0.12 mm. The pH and viscosity of optimized licorice oil-based emulgel was found to be 6.0±0.467 and 93,500±832 cps, respectively. Cumulative in vitro release was found to be 95.15±0.26 % has shown by the optimized formulation for 10 h. In (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT cytotoxicity study indicated non-toxic potential properties of licorice oil and its emulgel at lower level and caused moderate toxicity at higher level against Human Epidermal Keratinocytes (HaCaT) cell lines after the incubation period of 24 h respectively.
Conclusion: This study showed that the emulgel formulation has the potential to significantly enhance the efficacy of licorice oil in the treatment of psoriasis. These findings provide exciting new possibilities for improving psoriasis treatment and explores importance of continued research in this area.
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