PHYSICAL STABILITY AND SAFETY TESTING OF COSMETIC FORMULATIONS CONTAINING COLLAGEN FROM CATFISH (PANGASIUS SP.) SWIM BLADDER

MISDE YOLA; SUSY SAADAH; DENI RAHMAT

doi:10.22159/ijap.2024.v16s3.08

Authors

MISDE YOLA Department of Pharmacy. Universitas Pancasila, South Jakarta-12640, Indonesia. Department of Pharmaceutical and Food Analysis, Poltekkes Kemenkes Jakarta II, South Jakarta-12120, Indonesia
SUSY SAADAH Department of Pharmaceutical and Food Analysis, Poltekkes Kemenkes Jakarta II, South Jakarta-12120, Indonesia
DENI RAHMAT Department of Pharmacy. Universitas Pancasila, South Jakarta-12640, Indonesia

DOI:

https://doi.org/10.22159/ijap.2024.v16s3.08

Keywords:

Catfish, Collagen, In vivo, Formulation

Abstract

Objective: Collagen is a fibrous protein that confers strength and flexibility on bone and other body tissues, such as the skin and tendons, and is the main component of the extracellular matrix. It is used in cosmetics for its anti-ageing activity. The primary source of commercial collagen is pig skin, but its use is imperfect due to halal concerns and the risk of biological contamination. Therefore, this research was conducted to identify alternate sources of collagen derived from fish. This study used the swim bladders of catfish that were not consumed and sought to separate the collagen from and use it in a safe anti-ageing serum for humans.

Methods: Three formulations of 1%, 2%, and 3% collagen were developed in the laboratory using experimental methods. The three formulations were then evaluated for physical stability and in vivo irritation.

Results: Physical quality testing showed that the 1%, 2%, and 3% formulations remained stable at room, low, and high temperatures. However, in the irritation test, the 2% and 3% formulations resulted in mild erythema after 24, 48, and 72 h under constant conditions.

Conclusion: The 1% formula was confirmed stable and safe.

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