SURFACE SOLID DISPERSION OF MORINGA OLEIFERA LEAF EXTRACT-MICROCRYSTALLINE CELLULOSE PH 102-POLOXAMER 188: PREPARATION AND CHARACTERIZATION

KARINA C. RANI; ROISAH NAWATILA; ZULVIARA PD NATASYA; VERONIKA G. ANGELA; WINDA M WANTI; NIKMATUL IE JAYANI

doi:10.22159/ijap.2024v16s5.52466

Authors

KARINA C. RANI Departement of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Kalirungkut, Surabaya-60293, Indonesia https://orcid.org/0000-0003-2421-5754
ROISAH NAWATILA Departement of Pharmaceutical Biology, Faculty of Pharmacy, University of Surabaya, Kalirungkut, Surabaya-60293, Indonesia https://orcid.org/0000-0001-6920-5475
ZULVIARA PD NATASYA Departement of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Kalirungkut, Surabaya-60293, Indonesia
VERONIKA G. ANGELA Departement of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Kalirungkut, Surabaya-60293, Indonesia
WINDA M WANTI Departement of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Kalirungkut, Surabaya-60293, Indonesia
NIKMATUL IE JAYANI Departement of Pharmaceutical Biology, Faculty of Pharmacy, University of Surabaya, Kalirungkut, Surabaya-60293, Indonesia

DOI:

https://doi.org/10.22159/ijap.2024v16s5.52466

Keywords:

Moringa oleifera, Surface solid dispersion, Microwave irradiation

Abstract

Objective: The development of pharmaceutical products containing Moringa oleifera leaf extract has not developed well due to the physical and chemical characteristics limitations. The development of Surface Solid Dispersion (SSD) of Moringa oleifera leaves extract-microcrystalline cellulose PH102-Poloxamer 188 with 1:2:0.5 and 1:4:0.5 was performed in this study to improve the physicochemical characteristics of this extract.

Methods: SSD were prepared by microwave irradiation method using 400 W of power and 3 min of time exposure. The prepared SSD were evaluated for flowability, compressibility, moisture content, thermal characteristics (Differential Scanning Calorimetry (DSC)), crystallinity (Powder X-ray Diffractometry (PXRD)), functional group interaction (Fourier Transform Infra-Red Spectroscopy (FT-IR)), morphology (Scanning Electron Microscopy (SEM)), total flavonoid content, solubility study, and antioxidant activity.

Results: SSD powder exhibited better flowability, compressibility, and moisture content compared to the physical mixture (PM). The results of thermal characteristics and crystallinity of SSD indicate partial transformation into an amorphous phase. The total flavonoid content of SSD 1:2:0.5 was 11.04±0.23 mg QE/g, whereas SSD 1:4:0.5 was 9.18±0.05 mg QE/g. The solubility of the flavonoid compound from SSD 1:2:0.5 (78.73±0.76 µg/ml) and SSD 1:4:0.5 (61.90±3.38 µg/ml) was higher than PM with the equal ratio. The antioxidant activity was expressed as IC₅₀ values of SSD, which are 276.72±24.18 ppm for a 1:2:0.5 ratio and 249.04±27.29 ppm for a 1:4:0.5 ratio.

Conclusion: SSD preparation successfully improved the physicochemical characteristics and solubility of Moringa oleifera leaf extract. SSD 1:2:0.5 was the optimized composition from this study.

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