• ALI ESMAIL AL-SNAFI Department of Pharmacology, College of Medicine, Thiqar University, Iraq



Constituents, Pharmacology, Lagerstroemia speciosa


Lagerstroemia speciosa (Family: Lythraceae) is native to Asia-tropical and subtropical regions. The phytochemical investigation of Lagerstroemia speciosa leaf and fruit revealed that it contained steroids, terpenoids, glycosides, phenolic compounds, α-amino acids, saponins, starch, alkaloids, carbohydrates, organic acids, flavonoids, reducing sugars, tannins and many other active metabolites. Lagerstroemia speciosa possessed many Pharmacological effects included antimicrobial, antioxidant, anticancer, antidiabetic, hypolipidemic, antiobesity, anti-inflammatory, analgesic, gastrointestinal, diuretic, thrombolytic, cardiovascular, central nervous, inhibition of TNFα production, xanthine oxidase inhibitition, hepatoprotective and nephroprotective effects. The current review discussed the chemical constituents, pharmacological and therapeutic effects of Lagerstroemia speciosa.


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1. Al-Snafi AE. Chemical constituents and pharmacological activities of milfoil (Achillea santolina)-a review. Int J Pharm Tech Res 2013;5:1373-7.
2. Al-Snafi AE. The pharmaceutical importance of Althaea officinalis and Althaea rosea: a review. Int J Pharm Tech Res 2013;5:1387-5.
3. Al-Snafi AE. The pharmacological importance of Anethum graveolens-a review. Int J Pharm Pharm Sci 2014;6:11-3.
4. Al-Snafi AE. The pharmacology of Anchusa italica and Anchusa strigosa-A review. Int J Pharm Pharm Sci 2014;6:7-10.
5. Al-Snafi AE. Pharmacological and therapeutic importance of Hibiscus sabdariffa-A review. Int J Pharm Res 2018;10:451-75.
6. Al-Snafi AE. Immunological effects of medicinal plants: a review (part 2). Immunol Endocr Metab Agents Med Chem 2016;16:100-21.
7. The Plant List, Lagerstroemia speciosa. Available from: [Last accessed in 10 Apr 2019]
8. IT IS, Lagerstroemia speciosa. Available from: [Last accessed in 10 Apr 2019].
9. Philippine medicinal plants, Lagerstroemia speciosa. Available from: [Last accessed in 10 Apr 2019]
10. US National Plant Germplasm System, Lagerstroemia speciosa (L.) Pers. Available from: [Last accessed in 10 Apr 2019].
11. Takano J. Lagerstroemia Speciosa L. (Banaba or Queen's Flower)–Wonders of Botanical Herbs, Pyroenergen; 2013. Available from: products/banaba-plant.htm [Last accessed in 10 Apr 2019]
12. Castro IR. A guide to families of common flowering plants in the Philippines. Quezon City, The University of the Philippines Press; 2006. p. 106.
13. McMinn H, Maino E, Shepherd HW. An illustrated manual of pacific coast trees. Berkerly, University of Calfornia Press; 1980. p. 297.
14. Tropilab In, Lagerstroemia speciosa. Available from: [Last accessed in 10 Apr 2019].
15. Vardhana R. Direct uses of medicinal plants and their identification. New Delhi, Sarup and Sons; 2008. p. 203.
16. Wei D. Philippine medicinal plants–banaba, stuart xchange; 2003. [Last accessed in 10 Apr 2019]
17. Vardhana R. Direct uses of medicinal plants and their identification. New Delhi, Sarup and Sons; 2008. p. 203.
18. Thitikornpong W, Phadungcharoen T, Sukrong S. Pharmacognostic evaluations of Lagerstroemia speciosa leaves. J Med Plants Res 2011;5:1330-7.
19. Myint PP, Soe MT, Hlaing HH. A study of phytoconstituents, ?-glucosidase inhibitory effect and antioxidant activity of Lagerstroemia speciosa L. Leaf and fruit. J Pharmacogn Phytochem 2017;6:528-33.
20. Bhowmik NR, Mogha MR, Barua S. Characterization of phytoconstituents and evaluation of gastrointestinal motility and anticonvulsant activities of Lagerstroemia speciosa linn (bark). World J Pharm Sci 2016;4:309-13.
21. Hussain F, Ganguly A, Hossain MS, Rahman SMA. Analgesic and anti-diarrhoeal activities of Lagerstroemia speciosa roots in experimental animal model. Dhaka Univ J Pharm Sci 2014;13:57-62.
22. Thambi PT, Chacko SM, Chungath JI. Studies on the diuretic effect of Lagerstroemia speciosa Linn. leaf extracts in normal rats. Res J Pharm Biol Chem Sci 2013;4:1-9.
23. Bhaumik A, Ramu B, Rahman F, Basheer S, Mastanaiah J. The bioactive compounds of fruit of Lagerstroemia speciosa L. act as potential antimicrobial agent. Int J Pharm Res Health Sci 2014;2:476-80.
24. Hou W, Li Y, Zhang Q, Wei X, Peng A, Chen L. Triterpene acids isolated from Lagerstroemia speciosa leaves as ?-glucosidase inhibitors. Phytother Res 2009;23:614-8.
25. Jayakumar KS, Sajan JS, Aswati Nair R, Padmesh Pillai P, Deepu S, Padmaja R, Agarwal A, et al. Corosolic acid content and SSR markers in Lagerstroemia speciosa (L.) pers: a comparative analysis among populations across the Southern Western Ghats of India. Phytochemistry 2014;106:94-103.
26. Kolakul P, Sripanidkulchai B. Phytochemicals and anti-aging potentials of the extracts from Lagerstroemia speciosa and Lagerstroemia floribunda. Ind Crops Prod 2017;109:707-16.
27. Choi J, Cho JY, Choi SJ, Jeon H, Kim YD, Htwe KM, et al. Two new phenolic glucosides from Lagerstroemia speciosa. Molecules 2015;20:4483-91.
28. Kesavanarayanan KS, Sathiya S, Ranju V, Sunil AG, Ilavarasan R, Saravana Babu C, et al. In vitro cytotoxic, antioxidative and alpha-glucosidase inhibitory potential of a herbal mixture comprised of Allium sativum and Lagerstroemia speciosa. Eur Rev Med Pharmacol Sci 2012;16(Suppl 3):58-68.
29. Ragasa CY, Ngo HT, Rideout JA. Terpenoids and sterols from Lagerstroemia speciosa. J Asian Nat Prod Res 2005;7:7-12.
30. Bai N, He K, Roller M, Zheng B, Chen X, Shao Z, et al. Active compounds from Lagerstroemia speciosa, insulin-like glucose uptake-stimulatory/inhibitory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells. J Agric Food Chem 2008;56:11668-74.
31. Rahman SM, Pervin S, Quader A, Hossain MA. Phytochemical studies of the petroleum ether extract of the leaves of Lagerstroemia speciosa Linn. Indo J Chem 2009;9:470-3.
32. Takahashi M, Ueda J, Sasaki JI. The components of the plants of Lagerstroemia genus. IV. On the presence of the ellagic acid derivatives from the leaves of Lagerstroemia subcostata Koehne. and L speciosa (L.) Pers. and the synthesis of 3,4-di-o-methylellagic acid. Yakugaku Zasshi 1977;97:880-2.
33. Takahashi M, Osawa K, Ueda J, Yamamoto F, Tsai CT. The components of the plants of Lagerstroemia genus. III. On the structure of the new tannin (lagertannin) from the leaves of Lagerstroemia speciosa (L.) pers. Yakugaku Zasshi 1976;96:984-7.
34. Xu YM, Sakai T, Tanaka T, Nonaka G, Nishioka I. Tannins and related compounds CVI preparation of amino alditol derivatives of hydrolysable tannins having ?-and ? glucopyranose cores, and its application to the structure elucidation of new tannins reginins A and B and flosin A isolated from Lagerstroemia flosreginae retz. Chem Pharm Bull 1991;39:639 46.
35. Xu YM, Tanaka T, Nonaka G, Nishioka I. Tannins and related compounds CVII structure elucidation of three new monomeric and dimeric ellagitannins flosin B reginins C and D isolated from Lagerstroemia flosreginae retz. Chem Pharm Bull 1991;39:647 50.
36. Tanaka T, Tong HH, Xu YM, Ishimaru K, Nonaka G, Nishioka I. Tannins and related compounds. CXVII Isolation and characterization of three new ellagitannins lagerstannins A, B and C having a gluconic acid core from Lagerstroemia speciosa (L.). Pers Chem Pharm Bull 1992;40:2975 80.
37. Okada Y, Omae A, Okuyama T. A new triterpenoid isolated from Lagerstronemia speciosa (L.) pers. Chem Pharm Bull (Tokyo) 2003;51:452-4.
38. Jehan CM, Daulatabad D, Mirajkar A. A keto fatty acid from Lagerstroemia speciosa seed oil. Phytochemistry 1990;29:2323-4.
39. Sinhababu A, Das S, Laskar S, Thakur S, Sen SK. Characterization and identification of antibacterial components in extracts of seeds from Lagerstroemia speciosa. Adv Food Sci 1999;21:19-22.
40. Oloyede GK, Olandosu IA, Oloyade OO. Chemical composition and cytotoxic effect of Largerstroemia speciosa fruits essential oils. Int J Biol Chem Sci 2010;4:1851-4.
41. Thambi PT, Sabu MC, Chungath JI. Essential oils composition and cytotoxic effect of Lagerstroemia speciosa linn flowers. J Pharmacol Toxicol Studies 2016;4:1-5.
42. Sinhababu A, Basak B, Laskar S, Chakrabarty D, Sen SK. Effect of different fractions of petroleum ether (60-80 degrees) extracts of the seeds of Lagerstroemia speciosa (Linn ex Murray) pers on some microorganisms. Hind Antibiot Bull 1994;36:39-45.
43. Nasrin F, Ahmad S, Kamrunnahar. Evaluation of antimicrobial, lxidant and cytotoxic activities of methanolic extracts of Lagerstroemia speciosa leaves and barks. J Appl Pharm Sci 2012;2:142-7.
44. Saraswathi VS, Kamarudheen N, Bhaskara Rao KV, Santhakumar K. Biofilm inhibition formation of clinical strains of Pseudomonas aeruginosa mutans, the photocatalytic activity of azo dye and GC-MS analysis of leaves of Lagerstroemia speciosa. J Photochem Photobiol B 2017;169:148-60.
45. Ambujakshi HR, Surendra V, Haribabu T, Goli D. Antibacterial activity of leaves of Lagerstroemia speciosa (L) pers. J Pharm Res 2009;2:1028.
46. Sharmin T, Rahman MS, Mohammadi H. Investigation of biological activities of the flowers of Lagerstroemia speciosa, the Jarul flower of Bangladesh. BMC Complement Altern Med 2018;18:231.
47. Laruan LM, Balangcod TD, Balangcod K, Patacsil M. Phytochemical and antibacterial study of Lagerstroemia speciosa and its ethnomedicinal importance to indigenous communities of Benguet province, philippines. Acta Horticulturae 2014;1023:137-42.
48. Lai KH, Darah I, Wong CT, Afifah S, Lim SH. In vitro antibacterial activity and cytotoxicity of Lagerstroemia speciosa bark extract. Indian J Pharm Sci 2016;78:273-7.
49. Singh BN, Singh HB, Singh A, Singh BR, Mishra A, Nautiyal CS. Lagerstroemia speciosa fruit extract modulates quorum sensing-controlled virulence factor production and biofilm formation in Pseudomonas aeruginosa. Microbiology 2012;158:529-38.
50. Choi HJ, Bae EY, Song JH, Baek SH, Kwon DH. Inhibitory effects of orobol 7-O-D-glucoside from banaba (Lagerstroemia speciosa L.) on human rhinoviruses replication. Lett Appl Microbiol 2010;51:1-5.
51. Song JH, Park KS, Kwon DH, Choi HJ. Anti-human rhinovirus 2 activity and mode of action of quercetin-7-glucoside from Lagerstroemia speciosa. J Med Food 2013;16:274-79.
52. Nutan, Modi M, Goel T, Das T, Malik S, Suri S, et al. Ellagic acid and gallic acid from Lagerstroemia speciosa L inhibit HIV-1 infection through inhibition of HIV-1 protease and reverse transcriptase activity. Indian J Med Res 2013;137:540-8.
53. Park SW, Kwon MJ, Yoo JY, Choi HJ, Ahn YJ. Antiviral activity and possible mode of action of ellagic acid identified in Lagerstroemia speciosa leaves toward human rhinoviruses. BMC Complement Altern Med 2014;14:171.
54. Anil P, Manish S, Garvendra SR, Vijay B, Tarachand K. In vitro antioxidant studies of Lagerstroemia speciosa leaves. Phcog Net 2010;2:357-60.
55. Priya TT, Sabu MC, Jolly CI. Free radical scavenging and anti-inflammatory properties of Lagerstroemia speciosa (L). Inflammopharmacology 2008;16:182-7.
56. Unno T, Sakane I, Masumizu T, Kohno M, Kakuda T. Antioxidative activity of water extracts of Lagerstroemia speciosa leaves. Biosci Biotechnol Biochem 1997;61:1772-4.
57. Song JL, Zhao X, Wang Q, Zhang T. Protective effects of Lagerstroemia speciosa on 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in HIT-T15 pancreatic ? cells. Mol Med Rep 2013;7:1607-12.
58. Sung B, Kang YJ, Kim DH, Hwang SY, Lee Y, Kim M, et al. Corosolic acid induces apoptotic cell death in HCT116 human colon cancer cells through a caspase-dependent pathway. Int J Mol Med 2014;33:943-9.
59. Saraswathi VS, Saravanan D, Santhakumar K. Isolation of quercetin from the methanolic extract of Lagerstroemia speciosa by HPLC technique, its cytotoxicity against MCF-7 cells and photocatalytic activity. J Photochem Photobiol B 2017;171:20-6.
60. Rahman A, Uddin N, Hasanuzzaman M, Rahman AA. Antinociceptive antidiarrhoeal and cytotoxic activities of Lagerstroemia speciosa (L.) pers. Pharmacologyonline 2011;1:604-12.
61. Klein G, Kim J, Himmeldirk K, Cao Y, Chen X. Antidiabetes and anti-obesity activity of Lagerstroemia speciosa. Evid Based Complement Alternat Med 2007;4:401-7.
62. Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YM, Passwater R. Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in type II diabetics. A dose-dependence study. J Ethnopharmacol 2003;87:115-7.
63. Saumya SM, Basha PM. Antioxidant effect of Lagerstroemia speciosa pers (banaba) leaf extract in streptozotocin-induced diabetic mice. Indian J Exp Biol 2011;49:125-31.
64. Thuppia A, Rabintossaporn P, Saenthaweesuk S, Ingkaninan K, Sireeratawong S. The hypoglycemic effect of water extract from leaves of Lagerstroemia speciosa L in streptozotocin-induced diabetic rats. Songklanakarin J Sci Technol 2009;31:133-7.
65. Tanquilut NC, Tanquilut MRC, Estacio MAC. Hypoglycemic effect of Lagerstroemia speciosa (L) pers on alloxan-induced diabetic mice. J Med Plants Res 2009;3:1066-71.
66. Kakuda T, Sakane I, Takihara T, Ozaki Y, Takeuchi H, Kuroyanagi M. Hypoglycemic effect of extracts from Lagerstroemia speciosa L leaves in genetically diabetic KK-AY mice. Biosci Biotechnol Biochem 1996;60:204-8.
67. Hayashi T, Maruyama H, Kasai R, Hattori K, Takasuga S, Hazeki O, et al. Ellagitannins from Lagerstroemia speciosa as activators of glucose transport in fat cells. Planta Med 2002;68:173-5.
68. Ortiz MG. Effect of banaba (Lagerstroemia speciosa) on metabolic syndrome, insulin secretion and insulin sensitivity. University of Guadalajara; 2017. Available from: [Last accessed in 10 Apr 2019].
69. Bhokare KH, Upaganlawar AB. Neuroprotective effects of Lagerstroemia speciosa L. extract (Banaba leaf extract) in streptozotocine induced painful diabetic neuropathy in laboratory rats. Pharmacologia 2016;7:9-15.
70. Lampronti I, Khan MT, Bianchi N. Bangladeshi medicinal plant extracts inhibiting molecular interactions between nuclear factors and target DNA sequences mimicking NF-kappaB binding sites. Med Chem 2005;1:327-33.
71. Ichikawa H, Yagi H, Tanaka T, Cyong JC, Masaki T. Lagerstroemia speciosa extract inhibit TNF-induced activation of nuclear factor-kappaB in rat cardiomyocyte H9c2 cells. J Ethnopharmacol 2010;128:254-6.
72. Park C, Banaba LJ. The natural remedy as an antidiabetic drug. Biomed Res 2011;22:127-31.
73. Liu F, Kim J, Li Y, Liu X, Li J, Chen X. An extract of Lagerstroemia speciosa L has insulin-like glucose uptake-stimulatory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells. J Nutr 2001;131:2242-7.
74. Takagi S, Miura T, Ishihara E, Ishida T, Chinzei Y. Effect of corosolic acid on dietary hypercholesterolemia and hepatic steatosis in KK-Ay diabetic mice. Biomed Res 2010;31:213-8.
75. Suzuki Y, Unno T, Ushitani M, Hayashi K, Kakuda T. Antiobesity activity of extracts from Lagerstroemia speciosa L. leaves on female KK-Ay mice. J Nutr Sci Vitaminol (Tokyo) 1999;45:791-5.
76. Chong P, Beah Z, Grube B, Riede L. IQP-GC-101 reduces body weight and body fat mass: a randomized, double-blind, placebo-controlled study. Phytother Res 2014;28:1520–6.
77. Tjokroprawiro A, Murtiwi S, Tjandrawinata RR. DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa, in type-2 diabetes mellitus patients inadequately controlled by metformin and other oral antidiabetic agents. J Complement Integr Med 2016;13:413-20.
78. Manaf A, Tjandrawinata RR, Malinda D. Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa. Drug Des Dev Ther 2016;10:1279-89.
79. Gupta A, Agrawal VK, Rao CV. Exploration of analgesic and anti-inflammatory potential of Lagerstroemia speciosa. J Appl Pharm Sci 2017;7:156-61.
80. Morshed A, Hossain H, Shakil S, Nahar K, Rahman S, Ferdausi D, et al. Evaluation of the antinociceptive activity of two Bangladeshi medicinal plants, Kalanchoe pinnata (Lam.) pers and Lagerstroemia speciosa (L.) pers. Adv Nat Appl Sci 2010;4:193-7.
81. Chaudhary G, Mahajan UB, Goyal SN, Ojha S, Patil CR, Subramanya SB. Protective effect of Lagerstroemia speciosa against dextran sulfate sodium-induced ulcerative colitis in C57BL/6 mice. Am J Transl Res 2017;9:1792-800.
82. Chowdhury AR, Islam R, Muktadir AG. Thrombolytic activity of Lagerstroemia speciosa leaves. Discovery Phytomed 2017;4:41-5.
83. Sahu BD, Kuncha M, Rachamalla SS, Sistla R. Lagerstroemia speciosa L. attenuates apoptosis in isoproterenol-induced cardiotoxic mice by inhibiting oxidative stress: possible role of Nrf2/HO-1. Cardiovasc Toxicol 2015;15:10-22.
84. Sato K, Yagi M, Takabe W, Yonei Y. Inhibitory effect of plant extract on tumor necrosis factor-? formation from carboxymethyl lysine stimulated macrophages. Glycative Stress Res 2015;2:191-6.
85. Unno T, Sugimoto A, Kakuda T. Xanthine oxidase inhibitors from the leaves of Lagerstroemia speciosa (L.) pers. J Ethnopharmacol 2004;93:391-5.
86. Amresh G, Agarwal VK, Rao CV. Self micro emulsifying formulation of Lagerstroemia speciosa against chemically induced hepatotoxicity. J Tradit Complement Med 2017;8:164-9.
87. Priya TT, Sabu MC, Jolly CI. Amelioration of cisplatin induced nephrotoxicity in mice by an ethyl acetate extract of Lagerstroemia speciosa (L). J Basic Clin Physiol Pharmacol 2007;18:289-98.
88. Basha MP, Saumya SM. Influence of fluoride on streptozotocin-induced diabetic nephrotoxicity in mice: protective role of Asian ginseng (Panax ginseng) and banaba (Lagerstroemia speciosa) on mitochondrial oxidative stress. Indian J Med Res 2013;137:370-9.
89. Azad AK, Rahman MK, Sunzida NK. Acute oral toxicity study on Malaysian traditional herb: Lagerstroemia speciosa L. (Banaba). J Pharmacogn Phytochem 2015;4:228-32.
90. Talbott SM, Hughes K. The Health professional's guide to dietary supplements. Baltimore, Lippincott Williams, and Wilkins; 2007. p. 409-10.



How to Cite

AL-SNAFI, A. E. “MEDICINAL VALUE OF LAGERSTROEMIA SPECIOSA: AN UPDATED REVIEW”. International Journal of Current Pharmaceutical Research, vol. 11, no. 5, Sept. 2019, pp. 18-26, doi:10.22159/ijcpr.2019v11i5.35708.



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