CHEMICAL CONSTITUENTS AND PHARMACOLOGICAL EFFECTS OF LEPIDIUM SATIVUM-A REVIEW
DOI:
https://doi.org/10.22159/ijcpr.2019v11i6.36338Keywords:
Constituents, Pharmacology, Lepidium sativumAbstract
Lepidium sativum contained many bioactive constituents included cardiac glycoside, alkaloids, phenolic, flavonoids, cardiotonic glycosides, coumarins, glucosinolates, carbohydrates, proteins and amino-acids, mucilage, resins, saponins, sterols, tannins, volatile oils, triterpene, sinapic acid and uric acid. The pharmacological investigation revealed that Lepidium sativum possessed antimicrobial, antidiabetic, antioxidant, anticancer, reproductive, gastrointestinal, respiratory, anti-inflammatory, analgesic, antipyretic, cardiovascular, hypolipidemic, diuretic, central nervous, fracture healing and protective effects. The current review discussed the chemical constituents and pharmacological effects of Lepidium sativum.
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References
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4. Al-Snafi AE. The pharmacology of Anchusa italica and Anchusa strigosa-a review. Int J Pharm Pharm Sci 2014;6:7-10.
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10. Wadhwa S, Panwar MS, Agarwal A, Saini N, Patidar LN. A review on pharmacognostical study of Lepidium sativum. Adv Res Pharm Biol 2012;2(IV):316–23.
11. Raval ND, Pandya TN. Pharmacognostic study of Lepidium sativum Linn. Int Quarterly J Res Ayurveda 2011;32:116-9.
12. Brotonegoro S, Wiharti W. Lepidium sativum L. In: van Valkenburg, JLCH and Bunyapraphatsara N. (Eds). Plant Resources of South-East Asia No 12: Medicinal and poisonous plants 2. Backhuys Publishers, Leiden, Netherlands; 2001. p. 334–7.
13. Mukhopadhyay D, Parihar SS, Chauhan JS, Preeti, Joshi SC. Effect of temperature and desiccation on seed viability of Lepidium sativum L. New York Sci J 2010;3:34-6.
14. Datta PK, Diwakar BT, Viswanatha S, Murthy KN, Naidu KA. Safety evaluation studies on garden cress (Lepidium sativum L.) seeds in Wistar rats. Int J Appl Res Nat Prod 2011;4:37-43.
15. Al-Yahya M, Mossa J, Ageel A, Rafatullah S. Pharmacological and safety evaluation studies on Lepidium sativum L seeds. Phytomedicine 1994;1:155-9.
16. Chopra RN, Nayar SL, Chopra LC. Glossary of Indian medicinal plants. Council of Scientific and Industrial Research, New Delhi, India; 1986.
17. Ahsan SK, Tarig M, Ageel M, Alyanya MA, Shah AH. Studies on some herbaldrugs used in fracture healing. Int J Crude Drug Res 1989;27:235-9.
18. Sharma S, Agarwal N. Nourishing and healing prowess of garden cress (Lepidium sativum Linn). Indian J Nat Prod Res 2011;2:292-7.
19. Baytop T. Türkiye'de Bitkiler ile Tedavi. Nobel Tip Istanbul; 1999. p. 480-5.
20. Adam SIA, Salih SAM, Abdelgadir WS. In vitro antimicrobial assessment of Lepidium sativum L. seeds extracts. Asian J Med Sci 2011;3:261-6.
21. Mathews S, Singhal RS, Kulkarni PR. Some phsiochemical characteristics of Lepidium sativum seeds. Nahrung 1993;37:69-71.
22. Ahmad R, Mujeeb M, Anwar F, Husain A, Ahmad A, Sharma S. Pharmacognostical and phytochemical analysis of Lepidium sativum L seeds. Int Curr Pharm J 2015;4:442-6.
23. Gokavi SS, Malleshi NG, Guo M. Chemical composition of garden cress (Lepidium sativum) seeds and its fractions and use of bran as a functional ingredient. Plant Foods Human Nutr 2004;59:105-11.
24. Singh CS, Paswan VK, Naik B, Reeta. Exploring the potential of fortification by garden cress (Lepidium sativum L) seeds for development of functional foods. Indian J Natl Prod Res 2015;6:167-75.
25. Singh CS, Paswan. The potential of garden cress (Lepidium sativum L) seeds for development of functional foods. Chapter 4. In: Advances in seed biology. Intech; 2017. p. 279-94.
26. Ghante MH, Badole SL, Bodhankar SL. Health benefits of garden cress (Lepidium sativum Linn) seed extracts. Nuts and Seeds in Health and Disease Prevention; 2011. p. 521-5.
27. Chatoui K, Talbaoui A, Aneb M, Bakri Y, Harhar H, Tabyaoui M. Phytochemical screening, the antioxidant and antibacterial activity of Lepidium sativum seeds from morocco. J Mater Environ Sci 2016;7:2938-46.
28. Ghalem BR, Ali. Preliminary phytochemical screening of five commercial essential oils. World J Appl Chem 2017;2:145-51.
29. Zia-Ul-Haq M, Ahmad S, Calani L, Mazzeo T, Del Rio D, Pellegrini N, et al. Compositional study and antioxidant potential of Ipomoea hederacea Jacq and Lepidium sativum L seeds. Molecules 2012;17:10306-21.
30. Hussain I, Khattak MU, Riaz Ullah, Muhammad Z, Khan N, Khan FA, et al. Phytochemicals screening and antimicrobial activities of selected medicinal plants of Khyber Pakhtunkhwa, Pakistan. Afr J Pharm Pharmacol 2011;5:746-50.
31. Bryan RM, Shailesh NS, Jill KW, Steven FV, Roque LE. Composition and physical properties of cress (Lepidium sativum L) and field pennycress (Thlaspi arvense L) oils. Indus Crops Prod 2009;30:199-205.
32. Diwakara BT, Duttaa PK, Lokeshb BR, Naidu KA. Bioavailability and metabolism of n-3 fatty acid-rich garden cress (Lepidium sativum) seed oil in albino rats. Prostaglandins, Leukotrienes and Essential Fatty Acids 2008;78:123-30.
33. Alshammari GM, Yahya MA, Ahmed SB. Nutritive value of Elrashad (Lepidium sativum L) seeds grown in Saudi Arabia. J Exp Biol Agric Sci 2017;5(Suppl 1):S155-S158.
34. Abdel Karim M, Sufian A, Kamal MS, Inas O. Gc-Ms analysis and antimicrobial activity of fixed oil from Saudi Lepidium sativum (Crusifereae) seeds. Int J Adv Res 2017;5:1662-70.
35. Hussein HM. Analysis of trace heavy metals and volatile chemical compounds of Lepidium sativum using atomic absorption spectroscopy, gas chromatography-mass spectrometric and fourier-transform infrared spectroscopy. Res J Pharm Biol Chem Sci 2016;7:2529-55.
36. Nathawat RS, Mishra P, Patni V. Identification and qualitative analysis of ?-sitosterol and some phytoestrogens in in vivo and in vitro samples of Lepidium sativum: a semi-arid bone healing plant. Biochem Pharmacol (Los Angel) 2015;4:5.
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