NOVEL TOPICAL ANTI-AGING HERBAL COMPOSITION
DOI:
https://doi.org/10.22159/ijcpr.2023v15i1.2070Keywords:
Anti-agin, Bakuchiol, Celosia, In silico, Polyherbal, Sea buckthornAbstract
Objective: Anti-aging formulations are among the premier skin care products in the global market that are in huge demand. Different treatments are available to slow down skin aging, but are very expensive and are often found to produce adverse reactions to the skin in prolong use. Hence, present study has been designed to formulate poly herbal anti-aging skin care products and their evaluation thereon.
Methods: Anti-aging herbal skin care cream, gel and serum were prepared using two medicinal plants Hippophae salicifolia and Celosia argentea along with three bioactives caffeine, rutin and bakuchiol. The formulations were evaluated for physicochemical parameters like pH, texture analysis, acid value, short-term stability study, etc. Phenolics and flavanoid content were determined. Anti-aging potential was gauged by in silico studies using the glide tool of ‘Schrodinger’.
Results: Cream, gel and serum showed good physical appearance and were free from gritty particles and with smooth texture. Accelerated stability studies indicated insignificant changes in physicochemical parameters of the formulations. Based on the docking score and interaction with amino acid, compounds present in the plant extracts and bioactive showed good anti-aging activity.
Conclusion: The prepared herbal anti-aging formulations were found to be stable and exhibited good potential as an anti-aging combination. So, they can be used as an effective combination to protect skin from aging.
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References
Rasul A, Akhtar N. Formulation and in vivo evaluation for anti-aging effects of an emulsion containing basil extract using non-invasive biophysical techniques. Daru. 2011;19(5):344-50. PMID 22615680.
Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin anti-aging strategies. Dermatoendocrinol. 2012;4(3):308-19. doi: 10.4161/derm.22804, PMID 23467476.
Zhang S, Duan E. Fighting against skin aging: the way from bench to bedside. Cell Transplant. 2018;27(5):729-38. doi: 10.1177/0963689717725755, PMID 29692196.
Altuntaş E, Yener G. Antiaging potential of a cream containing herbal oils and honey: formulation and in vivo evaluation of effectiveness using the non-invasive biophysical technique. IOSR JPBS. 2015;10(6):51-60.
Jadoon S, Karim S, Bin Asad MH, Akram MR, Khan AK, Malik A. Anti-aging potential of phytoextract loaded-pharmaceutical creams for human skin cell longetivity. Oxid Med Cell Longev. 2015;2015:709628. doi: 10.1155/2015/709628, PMID 26448818.
Duraivel S, Shaheda SkA. Formulation and evaluation of antiwrinkle activity of cream and nano emulsion of topical vitamin C and the skin: Mechanisms of action and clinical applications. J Clin Aesthet Dermatol SK 2017;10(7):14-7.
Mishra AK, Mishra A, Chattopadhyay P. Herbal cosmeceuticals for photoprotection from ultraviolet B radiation: A review. Trop J Pharm Res 2011;10 (3):351-60.
Ravetti S, Clemente C, Brignone S, Hergert L, Allemandi D, Palma S. Ascorbic acid in skin health. Cosmetics. 2019;6(4):58. doi: 10.3390/cosmetics6040058.
Dhaliwal S, Rybak I, Ellis SR, Notay M, Trivedi M, Burney W. Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. Br J Dermatol. 2019;180(2):289-96. doi: 10.1111/bjd.16918, PMID 29947134.
Chaudhuri RK, Bojanowski K. Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. Int J Cosmet Sci. 2014;36(3):221-30. doi: 10.1111/ics.12117. PMID 24471735.
Takahashi K, Ishigami A. Anti-aging effects of coffee. Aging. 2017;9(8):1863-4. doi: 10.18632/aging.101287, PMID 28854150.
Li YF, Ouyang SH, Tu LF, Wang X, Yuan WL, Wang GE. Caffeine protects skin from oxidative stress-induced senescence through the activation of autophagy. Theranostics. 2018;8(20):5713-30. doi: 10.7150/thno.28778, PMID 30555576.
Choi SJ, Lee SN, Kim K, Joo da da H, Shin S, Lee J. Biological effects of rutin on skin aging. Int J Mol Med. 2016;38(1):357-63. doi: 10.3892/ijmm.2016.2604, PMID 27220601.
Kaur T, Singh G, Kapoor DN. A review on pharmacognostic, phytochemical and pharmacological data of various species of Hippophae (Sea buckthorn). Int J Green Pharm. 2017;11(1):62-75.
Pingalea SS, Salunke Gawalib S, Markandeyac AG, Firke NP. Recent developments in research of Celocia argentea: A review. J Pharm Res. 2012;2:1076-82.
Shah MB, Patel KN, Chauhan MG. Contribution to indigenous drugs part I: Celosia argentea. Int J Pharmacogn. 1993;31(3):223-34. doi: 10.3109/13880209309082946.
Ahmed AA, Nath B. Formulation and in vitro evaluation of poly-herbal anti-aging face cream of Coriandrum sativum and rose hip oil. Int J Curr Pharm Sci. 2017;9(4):75-8. doi: 10.22159/ijcpr.2017v9i4.20961.
Rao DS, Ramu S, Rama KG, Muneer SD. Design, characterization and evaluation of topical diclofenac sodium gel. Am J Adv Drug Deliv. 2013;1(4):565-71.
Shan S, Pyarry J, Junise. Formulation and evaluation fairness serum using polyherbal extracts. Int J Pharm. 2014;4(3):105-12.
Jadhav R, Patil PR, Patil PH. Formulation and evaluation of semisolid preparation (ointment, gel, serum) of thiocolchicoside. J Pharm Biomed Sci. 2011;8(1):1-6.
Sekar M, Sivalinggam P, Mahmad A. Formulation and evaluation of novel antiaging cream containing rambutan fruits extract. Int J Pharm Sci Res. 2017;8(3):1056-65.
Pękal A, Pyrzynska K. Evaluation of aluminium complexation reaction for flavonoid content assay. Food Anal Methods. 2014;7(9):1776-82. doi: 10.1007/s12161-014-9814-x.
Lovejoy B, Cleasby A, Hassell AM, Longley K, Luther MA, Weigl D. Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor. Science. 1994;263(5145):375-7. doi: 10.1126/science.8278810, PMID 8278810.
Würtele M, Hahn M, Hilpert K, Höhne W. Atomic resolution structure of native porcine pancreatic elastase at 1.1 A. Acta Crystallogr D Biol Crystallogr. 2000;56(4):520-3. doi: 10.1107/s0907444900000299, PMID 10739939.
Chao KL, Muthukumar L, Herzberg O. Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis. Biochemistry. 2007;46(23):6911-20. doi: 10.1021/bi700382g, PMID 17503783.
Osorio E, Bravo K, Cardona W, Yepes A, Osorio EH, Coa JC. Antiaging activity, molecular docking, and prediction of percutaneous absorption parameters of quinoline–hydrazone hybrids. Med Chem Res. 2019;28(11):1959-73. doi: 10.1007/s00044-019-02427-0.
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