IN SILICO DOCKING STUDY OF HERBAL COMPOSITION AND DEVELOPMENT OF MOUTH DISSOLVING TABLETS FOR COMMON RESPIRATORY DISEASES THEREOF

ANKITA CHANDWANI; KARUNA MODI; KAUSHIK SHAH; MAMTA SHAH

doi:10.22159/ijcpr.2024v16i4.5010

Authors

ANKITA CHANDWANI Department of Pharmacognosy, L. M. College of Pharmacy, Navrangpura, Ahmedabad-380009, Gujarat, India https://orcid.org/0000-0003-4518-5347
KARUNA MODI Department of Pharmacognosy, L. M. College of Pharmacy, Navrangpura, Ahmedabad-380009, Gujarat, India
KAUSHIK SHAH Sushen Medicamentos Pvt. Ltd., Ahmedabad-382213, Gujarat, India https://orcid.org/0009-0000-3926-7632
MAMTA SHAH Department of Pharmacognosy, L. M. College of Pharmacy, Navrangpura, Ahmedabad-380009, Gujarat, India https://orcid.org/0000-0002-4226-3939

DOI:

https://doi.org/10.22159/ijcpr.2024v16i4.5010

Keywords:

Accelerated stability study, Bioactive, Direct compression, Docking, In- silico studies, Super-disintegrant

Abstract

Objective: The present study aims to develop a novel mouth dissolving tablets containing a combination of herbal extracts and a bioactive constituent and evaluating it for activity against common respiratory diseases (in silico studies).

Methods: Docking study was done to provide a scientific foundation, keeping the traditional knowledge as a base. Four trial batches were developed. The final batch was then formulated and various pre and post-compression and assays were performed to evaluate the formation of good quality of product. The final batch was prepared by the method of direct compression and taken for accelerated stability studies.

Results: The final batch containing 10 % active ingredients, 7.5 % super-disintegrant and 47 % diluent was found to be stable, easily producible and economic.

Conclusion: This research work grasps possibilities for researchers in the development and evaluation of mouth-dissolving tablets with significant bioactive potential against common respiratory diseases.

Downloads

Download data is not yet available.

References

Respiratory diseases of adults. In: Speizer FE, Horton S, Batt J, Slutsky AS, Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB, Jha P, Mills A, Musgrove P. editors. Disease control priorities in developing countries. 2nd ed. Washington, (DC): International Bank for Reconstruction and Development/the World Bank; 2006. p. 1128-59.

European Respiratory Society. The global impact of respiratory disease. 2nd ed. Forum of International Respiratory Societies; 2017. p. 7-24.

GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the global burden of disease study 2015. Lancet. 2016;388(10053):1459-544. doi: 10.1016/S0140-6736(16)31012-1, PMID 27733281.

Bousquet J, Kaltaev N. Global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach. Geneva: World Health Organization; 2007. p. 146.

Burney PG, Patel J, Newson R, Minelli C, Naghavi M. Global and regional trends in COPD mortality, 1990-2010. Eur Respir J. 2015;45(5):1239-47. doi: 10.1183/09031936.00142414, PMID 25837037.

Global Asthma Network. The Global Asthma Report 2018. Auckland, New Zealand; 2018.

Pearce N, Ait Khaled N, Beasley R, Mallol J, Keil U, Mitchell E. Worldwide trends in the prevalence of asthma symptoms: phase III of the international study of asthma and allergies in childhood (ISAAC). Thorax. 2007;62(9):758-66. doi: 10.1136/thx.2006.070169, PMID 17504817.

World Health Organization, The United Nations Children’s Fund. Pneumonia: the forgotten killer of children. Geneva: United Nations Children’s Fund (United Nations Children’s Fund)/World Health Organization (WHO); 2006.

Kaur T, Gill B, Kumar S, Gupta GD. Mouth dissolving tablets: a novel approach to drug delivery. Int J Curr Pharm Res. 2011;3(1):1-7.

Chauhan K, Solanki R, Sharma S. A review on fast dissolving tablet. Int J App Pharm. 2018;10(6):1-7. doi: 10.22159/ijap.2018v10i6.28134.

Rathod S, Phansekar M, Bhagwan A, Surve G. A review on mouth dissolving tablets. Indian Drugs. 2013;50(11):5-14. doi: 10.53879/id.50.11.p0005.

Subramanian P, Nishan M. Biological activities of greater galangal, Alpinia galanga-a review. Res Rev J Bot Sci. 2015;5(2):28-41.

Zhou YQ, Liu H, He MX, Wang R, Zeng QQ, Wang Y. A review of the botany, phytochemical, and pharmacological properties of galangal. In: Grumezescu AM, Holban AM. editors. Natural and artifiial flavoring agents and food dyes, Handbook of food bioengineering. Vol. 7. Elsevier Inc.; 2018. p. 351-96.

Kaushik D, Yadav J, Kaushik P, Sacher D, Rani R. Current pharmacological and phytochemical studies of the plant Alpinia galanga. Zhong Xi Yi Jie He Xue Bao. 2011;9(10):1061-5. doi: 10.3736/jcim20111004, PMID 22015185.

Seo JW, Cho SC, Park SJ, Lee EJ, lee JH, Park DH, Kim BH. 1′-Acetoxychavicol acetate isolated from Alpinia galanga ameliorates ovalbumin-induced asthma in mice. Plos One. 2013;8(2):4-11.

Chouni A, Paul S. A review on phytochemical and pharmacological potential of Alpinia galanga. Pharmacogn J. 2017;10(1):9-15. doi: 10.5530/pj.2018.1.2.

Gopalakrishnan L, Doriya K, Kumar DS. Moringa oleifera: a review on nutritive importance and its medicinal application. Food Sci Hum Wellness. 2016;5(2):49-56. doi: 10.1016/j.fshw.2016.04.001.

Rani NZ, Husain K, Kumolosasi E. Moringa genus: a review of phytochemistry and pharmacology. Front Pharmacol. 2018;9(108):1-26.

Meireles D, Gomes J, Lopes L, Hinzmann M, Machado J. A review of properties, nutritional and pharmaceutical applications of Moringa oleifera: integrative approach on conventional and traditional Asian medicine. Adv Tradit Med. 2020;20(4):495-515. doi: 10.1007/s13596-020-00468-0.

Paikra BK, Dhongade HK, Gidwani B. Phytochemistry and pharmacology of Moringa oleifera lam. J Pharmacopuncture. 2017;20(3):194-200. doi: 10.3831/KPI.2017.20.022, PMID 30087795.

Kasolo JN, Bimenya GS, Ojok l, Ochieng J, Ogwal Okeng JW. Phytochemicals and uses of Moringa oleifera leaves in Ugandan rural communities. J Med Plants Res. 2010;4(9):753-7.

Rachmawati I, Rifa’i M. In vitro immunomodulatory activity of aqueous extract of moringa oleifera lam. Leaf to the CD4 +, CD8+ and B220+ Cells in Mus musculus. J Exp Life Sci. 2014;4(1):15-20. doi: 10.21776/ub.jels.2014.004.01.03.

Anudeep S, Prasanna VK, Adya SM, Radha C. Characterization of soluble dietary fiber from Moringa oleifera seeds and its immunomodulatory effects. Int J Biol Macromol. 2016;91:656-62. doi: 10.1016/j.ijbiomac.2016.06.013, PMID 27283233.

Agrawal B, Mehta A. Antiasthmatic activity of Moringa oleifera lam: a clinical study. Indian J Pharmacol. 2008;40(1):28-31. doi: 10.4103/0253-7613.40486, PMID 21264158.

Okwu DE. Citrus fruits: a rich source of phytochemicals and their roles in human health. Int J Chem Sci. 2008;6(2):451-71.

John S, Monica SJ, Priyadarshini S, Arumugam P, Gupta P. Investigation on phytochemical profile of Citrus limonum peel extract. Int J Food Sci Nutr. 2017;2(1):65-7.

Chauhan N, Saxena J. Phytochemical screening of yellow and green Citrus limon peel extracts in different solvents. Int Res J Pharm. 2019;10(4):121-5. doi: 10.7897/2230-8407.1004136.

Ali J, Das B, Saikia T. Antimicrobial activity of lemon peel (Citrus limon) extract. Int J Curr Pharm Sci. 2017;9(4):79-82. doi: 10.22159/ijcpr.2017v9i4.20962.

Oikeh EI, Omoregie ES, Oviasogie FE, Oriakhi K. Phytochemical, antimicrobial, and antioxidant activities of different citrus juice concentrates. Food Sci Nutr. 2016;4(1):103-9. doi: 10.1002/fsn3.268, PMID 26788316.

Oostwoud LC, Gunasinghe P, Seow HJ, Ye JM, Selemidis S, Bozinovski S. Apocynin and ebselen reduce influenza a virus-induced lung inflammation in cigarette smoke-exposed mice. Sci Rep. 2016;6:20983. doi: 10.1038/srep20983, PMID 26877172.

Stefanska J, Pawliczak R. Apocynin: molecular aptitudes. Mediators Inflamm. 2008;2008:106507. doi: 10.1155/2008/106507, PMID 19096513.

Hart BA, Copray S, Philippens I. Apocynin, a low molecular oral treatment for neurodegenerative disease. BioMed Res Int. 2014;2014:298020. doi: 10.1155/2014/298020, PMID 25140304.

Soares MP, Silva DP, Uehara IA, Ramos ES Jr, Alabarse PV, Fukada SY. The use of apocynin inhibits osteoclastogenesis. Cell Biol Int. 2019;43(5):466-75. doi: 10.1002/cbin.11110, PMID 30761659.

Heumuller S, Wind S, Barbosa Sicard E, Schmidt HH, Busse R, Schroder K. Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension. 2008;51(2):211-7. doi: 10.1161/Hypertensionaha.107.100214, PMID 18086956.

Stefanska J, Sarniak A, Wlodarczyk A, Sokolowska M, Pniewska E, Doniec Z. Apocynin reduces reactive oxygen species concentrations in exhaled breath condensate in asthmatics. Exp Lung Res. 2012;38(2):90-9. doi: 10.3109/01902148.2011.649823, PMID 22296407.

Semenya SS, Maroyi A. Data on medicinal plants used to treat respiratory infections and related symptoms in South Africa. Data Brief. 2018;21:419-23. doi: 10.1016/j.dib.2018.10.012, PMID 30364644.

Trott O, Olson AJ. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 2010;31(2):455-61. doi: 10.1002/jcc.21334, PMID 19499576.

Bagul U, Bagul N, Kulkarni M. Manufacturing technologies for mouth dissolving tablets. Pharm Rev. 2006.

Sahu V, Bakade B. Formulation and evaluation of mouth dissolving tablets. Int J Pharm Sci Res. 2012;3(12):4831-7.

Baba SA, Malik SA. Determination of total phenolic and flavonoid content, antimicrobial and antioxidant activity of a root extract of Arisaema jacquemontii blume. J Taibah Univ Sci. 2015;9(4):449-54. doi: 10.1016/j.jtusci.2014.11.001.

Chandra S, Khan S, Avula B, lata H, Yang MH, ElSohly MA. Assessment of total phenolic and flavonoid content, antioxidant properties, and yield of aeroponically and conventionally grown leafy vegetables and fruit crops: a comparative study. Evid Based Complement Alternat Med. 2014;2014:253875. doi: 10.1155/2014/253875, PMID 24782905.

International Conference on Harmonization. ICH. Q1A(R2) harmonised tripartite guideline. Stab Test New Drug Subst Prod; 2003. p. 1-18.