STUDY OF PREVALENCE OF SCRUB TYPHUS IN ACUTE FEBRILE ILLNESS IN A TERTIARY CARE HOSPITAL, VISAKHAPATNAM

Authors

  • THAMMINA MEHER SRI SAI SUDHA VANI Department of Microbiology, Andhra Medical College, King George Hospital, Visakhapatnam, Andhra Pradesh, India https://orcid.org/0000-0001-5816-951X

DOI:

https://doi.org/10.22159/ijcpr.2024v16i4.5046

Keywords:

Acute febrile illness, Scrub typhus, Prevalence, Eschar, ELISA

Abstract

Objective: Re-emergent cases of rickettsial disease, the scrub typhus is seen prevalent in cases of acute febrile illness. The objective of this study was to study the magnitude and prevalence of scrub typhus in a tertiary care hospital.

Methods: This prospective study was carried on for a period of one year from February 2023 to February 2024. Inpatients between the age group of 16 to 25 y with a triad of fever for more than 5 d of onset with or without an eschar, headache, myalgia and abnormal haematological and biochemical parameters were included in the study. IgM ELISA for scrub typhus was performed.

Results: Prevalence of scrub typhus in this study was 9.4% with higher male preponderance of 69.4% in 18 y age group 28.6%. Positive cases were recorded higher during post monsoon season of September 18.9%. Co-infection with dengue and malaria observed in 2 cases and ARDS was the complication in 3 cases. No mortality in this study.

Conclusion: It is important to get familiar with the clinical and diagnostic laboratory findings of scrub typhus so as to differentiate it from other aetiologies of acute febrile illness.

Downloads

Download data is not yet available.

References

Shankar V, Roopalatha M, lakshmi S. Scrub typhus in a tertiary care hospital in visakhapatnam, evolution. Med Dent Sci. 2019;8(40):3028-31. doi: 10.14260/jemds/2019/658.

Kore VB, Shital M. Mahajan, recent threat of scrub typhus in India: a narrative review, DMIHER school of epidemiology and public health, Cureus. Vol. 30092, Oct 9; 2022.

Ramyasree A, Kalawat U, Rani ND, Chaudhury A. Seroprevalence of scrub typhus at a Tertiary Care Hospital in Andhra Pradesh. Indian J Med Microbiol. 2015;33(1):68-72. doi: 10.4103/0255-0857.148381, PMID 25560004.

Venkategowda PM, Rao SM, Mutkule DP, Rao MV, Taggu AN. Scrub typhus: clinical spectrum and outcome. Indian J Crit Care Med. 2015;19(4):208-13. doi: 10.4103/0972-5229.154553, PMID 25878428.

Alice Peace Selvabai R, Shanmugan P, Kumaravelu R. Prevalence of scrub typhus among patients attending tertiary care hospital-a prospective and retrospective study. J Commun Disord. 2023;5592:48-52.

Varghese GM, Abraham OC, Mathai D, Thomas K, Aaron R, Kavitha ML. Scrub typhus among hospitalised patients with febrile illness in south India: magnitude and clinical predictors. J Infect. 2006;52(1):56-60. doi: 10.1016/j.jinf.2005.02.001, PMID 16368461.

Sharma N, Biswal M, kumar A, Zaman K, Jain S, Bhalla A. Scrub typhus in a Tertiary Care Hospital in North India. Am J Trop Med Hyg. 2016 Aug 3;95(2):447-51. doi: 10.4269/ajtmh.16-0086, PMID 27296391.

Rajoor U, Sindhur J, Dhananjaya M, Gundikeri S. Scrub typhus in adults in a teaching hospital in north Karnataka, 2011-2012. Ann Trop Med Public Health. 2013;6(6):614-7. doi: 10.4103/1755-6783.140221.

Scrub typhus IgM Microlisa, Microwell ELISA test for qualitative detection of scrub typhus IgM antibodies in human serum/plasma. J Mitra and Co Pvt Ltd; 2022.

Kelly DJ, Richards AL, Ternenak J. The past and present threat of rickettsial disease to military medicine and International public health, Clinical Infection Disease. 2002;34(Suppl 4):S145-69.

Chrispal A, Boorugu H, Gopinath KG, Prakash JA, Chandy S, Abraham OC. Scrub typhus: an unrecognized threat in South India–clinical profile and predictors of mortality. Trop Doct. 2010;40(3):129-33. doi: 10.1258/td.2010.090452, PMID 20360426.

Jain D, Nand N, Giri K. Scrub typhus infection, not a benign disease: an experience from a tertiary care center in Northern India. Med Pharm Rep. 2019 Jan;9291:36-42.

Mohapatra RK, Al-Haideri M, Mishra S, Mahal A, Sarangi AK, Khatib MN. Linking the increasing epidemiology of scrub typhus transmission in India and South Asia: are the varying environment and the reservoir animals the factors behind? Front Trop Dis 2024;5:1371905. doi: 10.3389/fitd.2024.1371905.

Taylar AC, Hill J, Kelly DJ. A serological survey of scrub, tick and endemic typhus in Sabah, East Malaysia, Southeast Asian. J Tropi Med Public Health. 1986;17:613-9.

Bonell A, Lubell Y, Newton PN, Crump JA, Paris DH. Estimating the burden of scrub typhus: a systematic review. PLoS Negl Trop Dis. 2017;11(9):e0005838. doi: 10.1371/journal.pntd.0005838, PMID 28945755.

Lakshmanan S, Benjamin Sagayaraj M, Sujatha B, Vasudevan LD. Clinical and laboratory profile of pediatric scrub typhus in a Tertiary Care Teaching Hospital in Southern India. Int J Contemp Pediatr. 2018;5(6):2092-7. doi: 10.18203/ 2349-3291.ijcp20183875.

Published

15-07-2024

How to Cite

VANI , T. M. S. S. S. “STUDY OF PREVALENCE OF SCRUB TYPHUS IN ACUTE FEBRILE ILLNESS IN A TERTIARY CARE HOSPITAL, VISAKHAPATNAM”. International Journal of Current Pharmaceutical Research, vol. 16, no. 4, July 2024, pp. 103-5, doi:10.22159/ijcpr.2024v16i4.5046.

Issue

Section

Original Article(s)