A RARE INSTANCE OF DIASTASE/PEPSIN–INDUCED HYPERSENSITIVITY REACTION

Authors

  • Navin Patil Dept of Pharmacology, Kasturba Medical College, Manipal University, Manipal
  • Karthik Rao N. Dept of Pharmacology, Kasturba Medical College, Manipal University, Manipal, India
  • Handattu Manjunatha Hande
  • A. Avinash Dept of Pharmacology, Kasturba Medical College, Manipal University, Manipal, India
  • Raghavendra Rao
  • Sushil Kiran Kunder
  • Anurag Pathak
  • Talha Ahmed

Keywords:

Digestive enzymes, Rash, Maculopapular, Allergy

Abstract

Diastase/Pepsin combination supplements are very commonly prescribed in clinical practice, mainly in the adult population. The chief indication for such use is indigestion or dyspepsia, wherein concomitant medication with proton pump inhibitors and antiemetics is also advised. Hypersensitivity reactions, though theoretically plausible with the use of digestive enzymes, there are no cases reported in the medical literature, to the best of our knowledge. This is one such case of hypersensitivity secondary to the administration of digestive enzymes in an adult Indian male.

Keywords: Digestive enzymes, Rash, Maculopapular, Allergy

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References

Harmon RC, Peura DA. Evaluation and management of dyspepsia. Ther Adv Gastroenterol 2010;3:87-98.

Barrett KE, Barman SM, Boitano S, Brooks HL. Gastrointestinal physiology. In: Ganong’s review of medical physiology. 23rd edition. The McGraw-Hill Companies; 2010.

https://www.mims.com/India/drug/info/ARISTOZYME/. [Last accessed on 03 Dec 2015].

http://www.drugsupdate.com/brand/generic/Diastase+Pepsin/48836/2. [Last accessed on 03 Dec 2015].

Stone SF, Phillips EJ, Wiese MD, Heddle RJ, Brown SGA. Immediate-type hypersensitivity drug reactions. Br J Clin Pharmacol 2014;78:1-13.

Published

01-05-2016

How to Cite

Patil, N., K. Rao N., H. M. Hande, A. Avinash, R. Rao, S. K. Kunder, A. Pathak, and T. Ahmed. “A RARE INSTANCE OF DIASTASE/PEPSIN–INDUCED HYPERSENSITIVITY REACTION”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 5, May 2016, pp. 421-2, https://journals.innovareacademics.in/index.php/ijpps/article/view/11124.

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