BRONCHOCONSTRICTION SECONDARY TO USE OF TOPICAL TIMOLOL IN A NON-ASTHMATIC PATIENT

Satish Nayak; Karthik Rao; Navin Patil; A. Avinash; Jayaprakash B.; N. R. Rau

doi:10.22159/ijpps.2016v8i10.12608

Authors

Satish Nayak Registrar, Department of Gastroenterology, Apollo Hospitals, Chennai, 2,5Department of Medicine
Karthik Rao Department of Medicine, Kasturba Medical College, Manipal University, Manipal
Navin Patil Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal
A. Avinash Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal
Jayaprakash B. Department of Medicine, Kasturba Medical College, Manipal University, Manipal
N. R. Rau Department of Medicine, Yenepoya Medical College, Mangalore

DOI:

https://doi.org/10.22159/ijpps.2016v8i10.12608

Keywords:

Topical beta blocker, Asthma, Timolol maleate, Glaucoma

Abstract

Ophthalmic application of a non-selective beta blocker like timolol maleate is known to produce bronchoconstriction in asthmatic individuals or patients with obstructive lung diseases. Timolol-induced bronchoconstriction in a previously healthy young adult without any pulmonary disease is rare. We report a case of a young adult who developed bronchoconstriction following ocular instillation of timolol maleate ophthalmic solution when he was treated for open-angle glaucoma.

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References

Diggory P, Franks W. Medical treatment of glaucoma-a reappraisal of the risks. Br J Ophthalmol 1996;80:85-9.

Diggory P, Heyworth P, Chau G, Mckenzie S, Sharma A. Unsuspected bronchospasm in association with topical Timolol: a common problem in the elderly. Age Ageing 1994;23:17-21.

Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet 2000;356:1255-9.

Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-45.

Hartwig SC, Siegel J, Schneider PJ. Preventability and severity assessment in reporting adverse drug reactions. Am J Hosp Pharm 1992;49:2229-32.

Diggory P, Cassels BA, Vail A, Abbey LM, Hillman JS. Avoiding unsuspected respiratory side-effects of topical timolol with cardioselective or sympathomimetic drugs. Lancet 1995;345:1604-6.