THE WONDERS OF A MEDICINAL TREE: HOLOPTELEA INTEGRIFOLIA (ROXB.) PLANCH
Keywords:
Holoptelea integrifolia, Ethnomedicinal property, Anti-inflammatory, Antioxidant, Anti-adherent, Anti-biofilmAbstract
In this busy era of herbal sciences, extensive study is being carried out on numerous plants to find novel drugs among which Holoptelea integrifolia Roxb. (Indian Elm) tree is just one of them. The age old knowledge ethnopharmacological significance, especially the stem, bark and leaves is well recognized in several Siddha, Ayurvedic, Unani literature. The plant parts are extensively used for its astringent, anti-inflammatory, digestive, carminative, laxative, depurative and diuretic properties. This plant is bestowed with a plethora of curative principles, namely antiviral, antimicrobial, antifungal, anti-arthritic, antioxidant, wound healing, anti-helminthic, anti-diabetic, anti-diarrheal, antiulcer, antitumor, adaptogenic, analgesic, hepatoprotective, larvicidal activities. Phytochemical investigation confirms the presence of signature chemical constituents such as terpenoids, alkaloids, glycosides, carbohydrates, steroids, sterols, saponins, tannins, proteins and flavonoids. The Recent discovery of antibacterial nature of callus promises of the discovery of callus derived novel antibiotics and unique drugs. The present review sheds light on current research trends in Holoptelea integrifolia with a serious look at its diverse ethnomedical uses as well as its prospect.
Downloads
References
Singh A. Exotic floristic diversity of Varanasi district of Uttar Pradesh, India. Indian J Plant Sci 2012;1:73-85.
Padmaja V, Srisailam K, Reddy VM. Pharmacognostic and preliminary phytochenical investigations on Holoptelea integrifolia. Pharmacogn J 2009;1:71-4.
Rastogi PR, Melhotra BM. Compendium of Indian Medicinal Plants. New Delhi National Institute of Science Communication; 1985-89. p. 375-83.
Mondal DN, Barik BR, Dey AK, Patra A, Kundu AB. Holoptelin A and B, two new triterpenoid fatty acids esters from Holoptelea integrifolia. Indian Drugs 1993;31:69-72.
Ahmed M, Rizwani GH, Mohammed EV, Mahmood I, Ahmed VU, Mahmud S. A Triterpenoid Antioxidant Agents found in Holoptelea integrifolia (Roxb) Planch. Int J Pharm Chem Biol Sci 2013;3:63-7.
Misra G, Bhatnagar SC, Nigam SK. 2a, 3a-Dihydroxyolean-12-en-28-oic acid from Holoptelea integrifolia heartwood. Planta Med 1975;27:290-7.
Misra G, Bhatnagar SC, Nigam SK. Constituents of Holoptelea integrifolia heartwood. Planta Med 1977;31:232-4.
Sutar RC, Kasture SB, Kalaichelvan VK. Isolation and identification of a new phytosterol from Holoptelea integrifolia (Roxb) planch leaves. Int J Pharm Pharm Sci 2014;6:354-7.
Biswas KM, Mallik H. Chemical investigation of Holoptelea integrifolia and Cassia fistula. J Indian Chem Soc 1986;63:448-9.
Jain R, Alam S, Jain S. 24-ethyl–cholest-22-en-3 alpha–ol and other constituents from the roots of Holoptelea integrifolia. Indian J Chem 1998;37:190-1.
Mishra DK, Somanta G, Mishra TK. Ethnomedicine of tribe Kharia of Midnapore district, West Bengal. Ethnobotany in South Asia. JK Mahalakshmi. Ed. Scientific Publishers, Jodhpur, India; 1996.
Singh VK, Ali ZA. Folk medicines in primary health care: common plants used for the treatment of fevers in India. Fitoterapia 1994;65:68-74.
Parinitham M, Harish GU, Vivek NC, Mahesh T, Shivanna MB. Ethnobotanical wealth of Bhadra wild life sanctuary in Karnataka. Indian J Traditional Knowledge 2004;3:37-50.
Kare MA, Dhabe AS, Bhuktar AS. Studies on crude drug Bark-Holoptelea integrifolia (Roxb.) Planch J Exp Sci 2011;2:9-11.
Pawar S, Patil DA. Ethnomedicinal uses of barks in Jalgaon district. Indian J Nat Prod Resour 2007;6:341-6.
Nandkani KM. Indian Materia Medica, Popular Prakashan Pvt. Ltd, Mumbai, India; 1976. p. 652.
Harsha VH, Hebbar SS, Shripathi V, GR Hegde. Ethnomedicobotany of Uttara Kannada district in Karnataka, India plants in treatment of skin diseases. J Ethnopharmacol 2003;84:37-40.
Bhuvad Sushama B, Nishteswar K. Ayurvedic and ethno-botanical perspective of chirabilva (Holoptelea integrifolia Planch). Int Ayurvedic Med J 2013;1:1-8.
Mahishi P, Srinivasa BH, Shivanna MB. Medicinal plant wealth of local communities in some villages in Shimoga district of Karnataka, India. J Ethnopharma 2005;98:307-12.
Singh H. Medicinal plants and their local uses in sub-himalayan tract of uttaranchal. Medicinal Plants: Ethnobotanical Approach. Agrobios. Ed. PC Trivedi. Jodhpur, India; 2006.
Khanna KK, Mudgal V, Shukla G, Shrivastav PK. Unreported ethnomedicinal uses of plants from Mirazapurdistrict, Uttar Pradesh. Ethnobot in South Asia. JK Mahalakshmi. Ed. Scientific Publishers, Jodhpur, India; 1996.
Sharma V, Hem K, Mishra A, Maurya SK. Time tested remedies for wound care from Ayurveda science. Innov J Ayurvedic Sci 2016;4:9-11.
Koppula Hemadri. A Treatise on Tribal Medicine. Koppula Hemadri’s House of Tribal Medicne, Vijayawada; 2011. p. 2, 4, 11, 13-4, 27, 35-7, 42, 44-5.
Singh KK, Prakash A. Observation on ethnobotany of Kol tribe of Varanasi district, Uttar Pradesh. Ethnobot in South Asia. JK Mahalakshmi. Ed. Scientific Publishers, Jodhpur, India; 1996.
Benjamin JKP, Christopher PKS. Preliminary phytochemical and pharmacognostic studies of Holoptelea integrifolia Roxb. Ethnobotanical Leaflets 2009;13:1222-31.
Beg MJ, Beg MZ, Ali SJ. Ethnomedicinal studies on sub-himalayan forest of North Eastern Utter Pradesh. Medicinal Plants: Ethnobot Approach. Agrobios. Ed. PC Trivedi. Jodhpur, India; 2006.
Khare CP. Indian Medicinal Plants an illustrated Dictionary. Spinger Science; 2007. p. 313.
Sharma S, Lakshmi K, Patidar A, Chaudhary A, Dhaker S. Studies on anti-inflammatory effect of aqueous extract of leaves of Holoptelea integrifolia Planch. in rats. Indian J Pharm 2009;41:87-8.
Kalpana, Upadhyay A. Anti-inflammatory evaluation of ethanolic extract of leaves of Holoptelea integrifolia planch. Scholars Res Library 2010;1:185-95.
Sharma S, Rai V, Kapoor B, Sarkar Bapi Rai. Phytochemical screening and evaluation of anti-inflammatory activity of leaves extract of Holoptelea integrifolia (Roxb). Int J Res Pharm Sci 2011;1:76-87.
Affan Z, Ghazala H Rizwani, Zahid H. Anti-nociceptive and anti-inflammatoy activities of Holpotelea integrifolia (Roxb). Planch fruit extract on laboratory animals. Afr J Pharm Pharmacol 2015;9:886-92.
Padmaa P, Durga N. Antibacterial activity of different extracts of stem bark of Holoptelea integrifolia. Int Res J Pharm 2011;2:111-3.
Ahmad S, Sharma R, Mahajan S, Agnihotri R, Gupta A. Antibacterial evaluation and preliminary phytochemical analysis of the leaf extract of Holoptelea integrifolia. J Pharm Res 2012;5:3823-5.
Vinod NV, Haridas M, Sadasivan C. Isolation of 1,4-naphthalenedione, an antibacterial principle from the leaves of Holiptelea integrifolia and its activity against β-lactame resistant Staphylococcus aureus. Indian J Biochem Biophy 2010;47:53-5.
Joshi SD, Hallikeri CS, Kulkarni VH. Evaluation of antibacterial and antitubercular activities of Holoptelea integrifolia (Roxb) Planch bark. Univ J Pharm 2013;2:87-90.
Rajbhandari M, Wegner U, Julich M, Schopke T, Mentel T. Screening of nepalese medicinal plants for antiviral activity. J Ethnopharmacol 2001;74:251-5.
Reddy BS, Reddy RKK, Naidu VGM. Evaluation of antimicrobial, antioxidant and wound-healing potentials of Holoptele integrifolia. J Ethnopharmacol 2008;115:249-56.
Sahoo KK, Yadav VK, Saxena AR. Antifungal properties of Holoptelea integrifolia (Roxb.) Planch. Ann Plant Protection Sci 2010;18:438-42.
Ishnava KB, Chauhan KH, Bhatt CA. Screening of antifungal activity of various plant leaves extracts from Indian plants. Arch Phytopathol Plant Prot 2012;45:152-60.
Nadella N, Paarakh PM. Evaluation of anthelmintic activity of Holoptelea integrifolia (Roxb.) planch. Int J Res Ayurveda Pharm 2011;1:637-41.
Kaur S, Kumar B, Puri S, Tiwari P, Divakar K. Comparative study of anthelmintic activity of aqueous and ethanolic extract of bark of Holoptelea integrifolia. Int J Drug Dev Res 2010;2:758-63.
Saraswathy A, Nandini DS, Ramasamy D. Antioxidant, heavy metals and elemental analysis of Holoptelea integrifolia Planch. Indian J Pharm Sci 2008;70:683-6.
Srivastava J, Dwivedi KN, Pandey HP. Antioxidant activity of methanolic extract from stem bark of the Holoptelea integrifolia planch. Int J Pharm Sci Rev Res 2014;24:104-9.
Sutar RC, Kalaichelvan VK. Evaluation of antioxidant activity of leaf extract of Holoptelea integrifolia (Roxb) Planch. Int J Appl Pharm 2014;6:6-8.
Lakshmi KS, Sharma SS, Rajesh T, Chitra V. Antitumour activity of ethanolic extract of leaves of Holoptelea integrifolia on Dalton’s ascitic lymphoma in Swiss albino mice. Int J Green Pharm 2010;4:44-7.
Soujanya J, Silambujanaki P, Leela Krishna V. Anticancer efficacy of Holoptelea integrifolia, planch. against 7, 12-dimethyl benz(a)anthracene induced breast carcinoma in experimental rats. Int J Pharm Pharm Sci 2011;3:103-6.
Guo H, Wang DS, Rizwani GH. Antineoplastic activity of Holoptelea integrifolia (Roxb.) planch bark extracts (in vitro). Pak J Pharm Sci 2013;26:1151-6.
Hemamalini K, Suvidha S, Bhargav A, Vasireddy U. Evaluation of anti-ulcer activity of methanolic extracts of Kigelia africana, Sophara interrupta and Holoptelea integrifolia leaves in experimental rats. Int J Curr Pharm Res 2012;4:61-6.
Mamatha MK. Phytochemical investigation and antidiabetic activity of Holoptelea integrifolia planch [M. S. thesis], KLE University, Karnataka, India; 2009.
Sharma S, Khatri P, Pandey A, Jakhetia V, Chaturvedi L, Dwivedi N. Anti-diabetic screening of leaves extract of Holoptelea integrifolia roxb. Int J Pharm Res Dev 2010;2:66-71.
Sharma J, Sharma SC, Sarangdevot YS, Vyas B. Study of antidiabetic activity of the stem bark extract of Holoptelea integrifolia (Roxb.). Res J Pharmacol Pharm 2012;4:181-4.
Shrinivas S, Lakshmi KS, Rajesh T. Evaluation of antidiarrhoeal potentials of ethanolic extract of leaves of Holoptelea integrifolia in mice model. Int J Pharm Res 2009;1:832-6.
Kumar B, Puri S, Debnath J, Salhan M, kaur M, Mittal A. Comparative pharmacological evaluation of adaptogenic activity of Holoptelea integrifolia and Withania somnifera. Int J Drug Dev Res 2011;3:84–98.
Rizwani GH, Mahmud S, Shareef H, Perveen R, Ahmed M. Analgesic activity of various extracts of Holopteleaintegrifolia (Roxb) planch leaves. Pak J Pharm Sci 2012;25:629-32.
Subhash AK, Augustine A. Hypolipidaemic effects of methanolic extract of Holoptelea integrifolia (Roxb.) planchon bark in diet-induced obese rats. Appl Biochem Biotechnol 2013;169:546-53.
Hemamalini K, Sathya SB. Hepatoprotective activityof Sophara interrupta and Holoptelea integrifolia against carbon-tetrachloride induced hepatotoxicity in rats. Int J Biol Pharm Allied Sci 2013;2:80-9.
Shrinivas S, Ravindra K, Aradhana M, Kailash B. Ethanolic leaf extract of Holoptelea integrifolia Planch decreases cisplatin-induced pica in rats. J Pharmacogn 2008;7:293-7.
Singha S, Adhikari U, Ghosh A, Chandra G. Mosquito larvicidal potentiality of Holoptelea integrifolia leaf extract against Japanese Encephalitis Vector, Culex vishuni. J Mosque Res 2012;2:25–31.
Hemamalini K, Soujanya LG, Vasireedy U, Pavani P. CNS activity of the methanolic leaf extracts of Sophora interrupta Bedd, Kigelia pinnata Dc, Holoptelea integrifolia plants in experimental animal models. Int J Pharm Technol 2011;3:3785-91.
Sutar RC, Kasture SB, Kalaichelvan VK. Screening of leaf extracts of Holoptelea integrifolia (Roxb.) planch for it’s antiarthritic activity in experimental animals. Int J Pharm Res 2014;6:1526-32.
Sutar RC, Kasture SB, Kalaichelvan VK. Evaluation of anticonvulsant activity of leaf extract of Holoptelea integrifolia (Roxb) planch in experimental animals. Int J Pharm Pharm Sci 2014;6:308-11.