• Mukesh Gohel Anand Pharmacy College, Anand, Gujarat, India
  • Ankita Purohit Anand Pharmacy College, Anand, Gujarat, India
  • Asha Patel Parul Institute of Pharmacy and Research, Vadodara, Gujarat, India
  • Lal Hingorani Pharmanza Herbal Pvt. Ltd, Dharmaj, Gujarat, India




Bacoside A, Solubility, D-optimal mixture design, Bioavailability


Objective: The objective of present study is to enhance solubility and bioavailability of poorly soluble bacoside A present in Bacopa monnieri extract using self nano emulsifying drug delivery system (SNEDDS) for the treatment of Alzheimer's disease.

Methods: Solubility of the drug was assessed in various oils (edible as well as synthetic oil), surfactant and co-surfactant by saturation solubility study. Pseudo-ternary phase diagram was used to obtain appropriate concentration ranges of components include oil, surfactant and co-surfactant.

Results: From the result of saturated solubility study and phase diagram, oleic acid, tween 20 and ethanol was selected as oil, surfactant and co-surfactant. The D-Optimal mixture design was used to optimize the formulation on the basis of solubility of drug and dilution potential. In vitro dissolution, study showed 89% of drug release from optimized SNEDDS formulation compared to untreated drug extract with 24% of drug release in 60 min. Ex vivo diffusion study showed more than 90% of drug diffused from optimized SNEDDS formulation compared to pure extract.

Conclusion: In a nutshell, the developed SNEDDS formulation using the design of experimentation approach held great potential as a possible alternative to traditional oral formulations of poorly soluble Bacoside A to improve solubility and bioavailability.


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How to Cite

Gohel, M., A. Purohit, A. Patel, and L. Hingorani. “OPTIMIZATION OF BACOSIDE A LOADED SNEDDS USING D-OPTIMAL MIXTURE DESIGN FOR ENHANCEMENT INSOLUBILITY AND BIOAVAILABILITY”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 12, Dec. 2016, pp. 213-20, doi:10.22159/ijpps.2016v8i12.13488.



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