MEMBRANE MARKER SENSORY STRATEGY (MMSS) IS A NEW CONCEPT IN CANCER THERAPY: A HYPOTHESIS

Authors

  • Md. Torequl Islam Department of Pharmacy, Mehedibag (Chittagong)-4000, Bangladesh, Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina (Piauí)-64.049-550, Brazil

DOI:

https://doi.org/10.22159/ijpps.2016v8i12.14211

Keywords:

Hypothesis, Membrane marker, Novel strategy, Cancer therapy

Abstract

Cancer, the group of diseases, is characterized by an abnormal cell growth and function, thus the complications in physiological homeostasis. Although, not all tumors are cancerous, but after a certain time/biological events they may turn into cancer. That means, it is always a risk to continue with any type of tumor. Over 100 cancers are affecting human are detected till date. Treatments belong to the types and stages of cancers along with the areas (physiological). However, there is no single cancer therapy, which is free from side effects. Additionally, complications in cellular targeting and therapy-induced second cancer are also evident. Combination treatments are also used in some cases, despite the possibility of immunosuppression and a bundle of unavoidable events. Otherwise, cancer treatment in advanced stages and metastasize are yet being considered. Therefore, scientists are always in search for a new and effective mode of cancer treatment, so that they may ensure less or even no side effects with a promising survival rate. In fact, the economy, safety, and effectiveness are the deemed query of both the patients and physicians. Among the others, the markers coming from the changed cell membrane of a cancerous cell may be good sources to ligand targeting, as these are the basic differentiating matter between a normal and cancer cell. In this hypothesis, the membrane marker sensory strategy is going to be introduced theoretically for the first time may be an alternative and effective mode of cancer treatment.

Downloads

Download data is not yet available.

References

Daisy P, Suveena S. A review on comprehensive cancer pathways. Int J Appl Pharm 2014;6:1-5.

Jayapriya M, Muhammad SA, Ravi S. Synthesis, anticancer activity, molecular docking, and absorption, distribution, metabolism, and excretion toxicity studies of novel benzothiazines. Asian J Pharm Clin Res 2016;9:61-5.

NCI (National Cancer Institute). Lung cancer patient outcomes better at high-volume treatment centers than low-volume treatment centers; 2016. p. 1.

CRUK (Cancer Research UK); 2016. Available from http://www.cancerresearchuk.org/about-cancer/cancers-in-general/treatment/transplant/side-effects-of-bone-marrow-and-stem-cell-transplants. [Last accessed on 10 Jun 2016].

Saxena R, Khan F, Masood M, Qureshi Z, Rathore M. Review on organ transplantation: a social, medical need. J Crit Rev 2016;3:23-9.

ACS (American Cancer Society). RFA: The role of health policy and health insurance in improving access to and performance of cancer prevention, early detection, and treatment services; 2016.

AFP (American Family Physician); 2016. Available from: http://www.aafp.org/afp/2011/0315/p719.html. [Last accessed on 10 Jun 2016].

Verma M, Rogers S, Divi RL, Schully SD, Nelson S, Su LJ, et al. Epigenetic research in cancer epidemiology: trends, opportunities, and challenges. Cancer Epidemiol Biomarkers Prev 2014;23:223-33.

Weber GF. Why does cancer therapy lack effective anti-metastasis drugs? Cancer Lett 2013;328:207-11.

Saka S, Singh AN, Sharma N. Potential anti-cancer superfoods: a minireview. Int J Curr Pharm Res 2016;8:19-21.

Sanigaram V, Lingampally S, Boyana A, Vurumadla S. A prospective study on clinical evaluation, treatment pattern and adverse effects of anticancer drugs in various gynecological cancer patients. Asian J Pharm Clin Res 2015;8:125-31.

Royer C, Lu X. Epithelial cell polarity: a major gatekeeper against cancer? Cell Death Differ 2011;18:1470-7.

Li P, Mao X, Ren Y, Liu P. Epithelial cell polarity determinant CRB3 in cancer development. Int J Biol Sci 2015;11:31-7.

Lee M, Vasioukhin V. Cell polarity and cancer–cell and tissue polarity as a non-canonical tumor suppressor. J Cell Sci 2008;121:1141-50.

Partanen JI, Tervonen TA, Klefström J. Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4. Philos Trans R Soc London Ser B 2013;368. Doi:10.1098/rstb.2013.0111

Krawchuk D, Anani S, Honma-Yamanaka N, Polito S, Shafik M, Yamanaka Y. Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo. J Cell Sci 2015;128:1011-22.

Scott H. Phosphatidylserine, a lipid present at the outer membrane leaflet of cancer cells, hinders the insertion of pHLIP, a potential cancer cell marker. Biophys J 2015;108:552a.

Published

01-12-2016

How to Cite

Islam, M. T. “MEMBRANE MARKER SENSORY STRATEGY (MMSS) IS A NEW CONCEPT IN CANCER THERAPY: A HYPOTHESIS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 12, Dec. 2016, pp. 314-7, doi:10.22159/ijpps.2016v8i12.14211.

Issue

Section

Hypothesis

Most read articles by the same author(s)