SYNTHESIS AND ANTIOXIDANT ACTIVITY OF 2-SUBSTITUTED-5-NITRO BENZIMIDAZOLE DERIVATIVES

Sabrina Rahman Archie; Biplab Kumar Das; Md. Shahadat Hossain; Uttom Kumar; Abu Shara Shamsur Rouf

doi:10.22159/ijpps.2017v9i1.14972

Authors

Sabrina Rahman Archie Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
Biplab Kumar Das Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
Md. Shahadat Hossain Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
Uttom Kumar Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
Abu Shara Shamsur Rouf Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

DOI:

https://doi.org/10.22159/ijpps.2017v9i1.14972

Keywords:

Benzimidazole, synthesis, antioxidant, DPPH

Abstract

Objective: This study was conducted to synthesise some 2-substituted-5-nitro benzimidazole derivatives to evaluate their antioxidant activity.

Methods: The titled compounds were synthesised by sodium metabisulfite mediated reaction of 4-nitro-1, 2-phenylenediamine with a number of para-substituted benzaldehydes. The antioxidant activity was evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method.

Results: All the compounds exhibited good antioxidant activity having IC₅₀ values in the range of 3.17 to 7.59 Âµg/ml while that of standard butylated hydroxytoluene (BHT) was 18.42 Âµg/ml.

Conclusion: Among the synthesised compounds, compounds 3a-c have been shown to possess the most prominent antioxidant activity which might be attributed due to the presence of chloro, bromo and fluoro substituents in the molecule. The compounds may act as the future lead(s) for the development of potential antioxidant compounds.

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