ANTIINFLAMMATORY AND ANTIOXIDANT ACTIVITIES OF 2-AMINO-N-(SUBSTITUTED ALKYL) BENZOXAZOLE-5-CARBOXAMIDE DERIVATIVES
Keywords:
Benzoxazole, Synthesis, Antiinflammatory, AntioxidantAbstract
Objective: In continuation of the work on Benzoxazoles present work deals with the synthesis,characterization and evaluation of 2-Amino-N-(substituted alkyl) benzoxazole-5- carboxamides for anti-inflammatory and antioxidant activities.
Methods: Synthetic methodology of benzoxazoles from 4-carbomethoxynitrophenol.Evaluation of compounds for anti-inflammatory activity by carragenean induced rat paw odema method and antioxidant activity by DPPH method.
Results: Among them compounds Vc(R=ethyl), Ve(R=propyl) and Vg (R=diisopropyl) V g (R=propyl) were found to be potent compounds. Compound Vf (R=isopropyl) showed comparatively more percentage of free radical scavenging activity with IC 50 of 4.65 when compared with the standard ascorbic acid.
Conclusion: Vf is considered to be the dual anti-inflammatory and antioxidant agent.
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References
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